Search Results - "The pharmacogenomics journal"

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters by Graessler, J, Qin, Y, Zhong, H, Zhang, J, Licinio, J, Wong, M-L, Xu, A, Chavakis, T, Bornstein, A B, Ehrhart-Bornstein, M, Lamounier-Zepter, V, Lohmann, T, Wolf, T, Bornstein, S R

“…Roux-en-Y gastric bypass (RYGB) has become a prominent therapeutic option for long-term treatment of morbid obesity and type 2 diabetes mellitus (T2D). Cross…”
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Cancer's epigenetic drugs: where are they in the cancer medicines? by Ghasemi, Sorayya

“…Epigenetic modulation can affect the characteristics of cancers. Because it is likely to manipulate epigenetic genes, they can be considered as potential…”
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Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs by Wang, D, Guo, Y, Wrighton, S A, Cooke, G E, Sadee, W

“…Cytochrome P450 3A4 (CYP3A4) metabolizes ∼50% of all clinically used drugs. Although CYP3A4 expression varies widely between individuals, the contribution of…”
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HLA-A31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis by Genin, E, Chen, D-P, Hung, S-I, Sekula, P, Schumacher, M, Chang, P-Y, Tsai, S-H, Wu, T-L, Bellón, T, Tamouza, R, Fortier, C, Toubert, A, Charron, D, Hovnanian, A, Wolkenstein, P, Chung, W-H, Mockenhaupt, M, Roujeau, J-C

“…HLA-A*31:01 was reported to be associated with carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCAR), including drug reaction with eosinophilia…”
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Genotype, phenotype, and medication recommendation agreement among commercial pharmacogenetic-based decision support tools by Bousman, Chad A., Dunlop, Boadie W.

“…The degree of agreement between four commercial pharmacogenetic-based decision support tools (DSTs) was examined in five outpatients with major depressive…”
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Drug–drug–gene interactions and adverse drug reactions by Malki, Mustafa Adnan, Pearson, Ewan Robert

“…The economic and health burden caused by adverse drug reactions has increased dramatically in the last few years. This is likely to be mediated by increasing…”
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Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet? by Verbelen, M, Weale, M E, Lewis, C M

“…Pharmacogenetics (PGx) has the potential to personalize pharmaceutical treatments. Many relevant gene–drug associations have been discovered, but PGx-guided…”
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The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis by Koonrungsesomboon, Nut, Khatsri, Rapheephorn, Wongchompoo, Penwisa, Teekachunhatean, Supanimit

“…A large interindividual variation in the activity of cytochrome P450 1A2 (CYP1A2) raises concern about therapeutic failure or toxicity when medical…”
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CYP3A5 gene polymorphisms and their impact on dosage and trough concentration of tacrolimus among kidney transplant patients: a systematic review and meta-analysis by Khan, Abdul Rafay, Raza, Ali, Firasat, Sadaf, Abid, Aiysha

“…Tacrolimus is an immunosuppressive drug widely used in kidney transplantation. Cytochrome P450 3A5 (CYP3A5) protein is involved in tacrolimus metabolism…”
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Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer by Graziano, F, Ruzzo, A, Giacomini, E, Ricciardi, T, Aprile, G, Loupakis, F, Lorenzini, P, Ongaro, E, Zoratto, F, Catalano, V, Sarti, D, Rulli, E, Cremolini, C, De Nictolis, M, De Maglio, G, Falcone, A, Fiorentini, G, Magnani, M

“…Production of lactate even in the presence of sufficient levels of oxygen (aerobic glycolysis) seems the prevalent energy metabolism pathway in cancer cells…”
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HIBAG—HLA genotype imputation with attribute bagging by Zheng, X, Shen, J, Cox, C, Wakefield, J C, Ehm, M G, Nelson, M R, Weir, B S

“…Genotyping of classical human leukocyte antigen (HLA) alleles is an essential tool in the analysis of diseases and adverse drug reactions with associations…”
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A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease by Roses, A D, Lutz, M W, Amrine-Madsen, H, Saunders, A M, Crenshaw, D G, Sundseth, S S, Huentelman, M J, Welsh-Bohmer, K A, Reiman, E M

“…The ɛ4 allele of the apolipoprotein E ( APOE ) gene is currently the strongest and most highly replicated genetic factor for risk and age of onset of…”
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COMT val158met moderation of dopaminergic drug effects on cognitive function: a critical review by Schacht, J P

“…The relationship between dopamine (DA) tone in the prefrontal cortex (PFC) and PFC-dependent cognitive functions (for example, working memory, selective…”
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ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout by Roberts, R L, Wallace, M C, Phipps-Green, A J, Topless, R, Drake, J M, Tan, P, Dalbeth, N, Merriman, T R, Stamp, L K

“…Many patients fail to achieve the recommended serum urate (SU) target (<6 mgdl −1 ) with allopurinol. The aim of our study was to examine the association of…”
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Polymorphisms of ABCC5 and NOS3 genes influence doxorubicin cardiotoxicity in survivors of childhood acute lymphoblastic leukemia by Krajinovic, M, Elbared, J, Drouin, S, Bertout, L, Rezgui, A, Ansari, M, Raboisson, M-J, Lipshultz, S E, Silverman, L B, Sallan, S E, Neuberg, D S, Kutok, J L, Laverdière, C, Sinnett, D, Andelfinger, G

“…Anthracyclines are efficient chemotherapy agents. However, their use is limited by anthracycline-induced cardiotoxicity (CT). We investigated the influence of…”
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Impact of CYP1A2, CYP2C19, and CYP2D6 genotype- and phenoconversion-predicted enzyme activity on clozapine exposure and symptom severity by Lesche, Dorothea, Mostafa, Sam, Everall, Ian, Pantelis, Christos, Bousman, Chad A.

“…Clozapine is an atypical antipsychotic metabolized by CYP1A2 , CYP2D6 , and CYP2C19 enzymes. Among 66 adult schizophrenia patients treated with clozapine-based…”
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An optimized prediction framework to assess the functional impact of pharmacogenetic variants by Zhou, Yitian, Mkrtchian, Souren, Kumondai, Masaki, Hiratsuka, Masahiro, Lauschke, Volker M.

“…Prediction of phenotypic consequences of mutations constitutes an important aspect of precision medicine. Current computational tools mostly rely on…”
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Association of UGT1A128 polymorphisms with irinotecan-induced toxicities in colorectal cancer: a meta-analysis in Caucasians by Liu, X, Cheng, D, Kuang, Q, Liu, G, Xu, W

“…A meta-analysis in Caucasians was conducted to investigate the possible association of uridine diphosphate glucuronosyltransferase (UGT) 1A1 gene polymorphisms…”
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The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data by Zhou, Yitian, Lauschke, Volker M.

“…Genes encoding cytochrome P450 enzymes (CYPs) are extremely polymorphic and multiple CYP variants constitute clinically relevant biomarkers for the guidance of…”
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A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma by Spear, Melissa L., Hu, Donglei, Pino-Yanes, Maria, Huntsman, Scott, Eng, Celeste, Levin, Albert M., Ortega, Victor E., White, Marquitta J., McGarry, Meghan E., Thakur, Neeta, Galanter, Joshua, Mak, Angel C. Y., Oh, Sam S., Ampleford, Elizabeth, Peters, Stephen P., Davis, Adam, Kumar, Rajesh, Farber, Harold J., Meade, Kelley, Avila, Pedro C., Serebrisky, Denise, Lenoir, Michael A., Brigino-Buenaventura, Emerita, Cintron, William Rodriguez, Thyne, Shannon M., Rodriguez-Santana, Jose R., Ford, Jean G., Chapela, Rocio, Estrada, Andrés Moreno, Sandoval, Karla, Seibold, Max A., Winkler, Cheryl A., Bleecker, Eugene R., Myers, Deborah A., Williams, L. Keoki, Hernandez, Ryan D., Torgerson, Dara G., Burchard, Esteban G.

“…Short-acting β 2 -adrenergic receptor agonists (SABAs) are the most commonly prescribed asthma medications worldwide. Response to SABAs is measured as…”
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