Search Results - "The open pharmacology journal"

Neuroprotection in Parkinson's Disease: A Systematic Review of the Preclinical Data by Douna, H., Bavelaar, B.M., Pellikaan, H., Olivier, B., Pieters, T.

“…Aim: This study aimed to systematically review the preclinical data of neuroprotective agents for Parkinson’s disease (PD) to support the translation of these…”
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CEACAM1 is a Privileged Cell Surface Antigen to Design Novel ScFv Mediated-Immunotherapies of Melanoma, Lung Cancer and Other Types of Tumors by Cianfriglia, Maurizio, Fiori, Valentina, Dominici, Sabrina, Zamboni, Silvia, Flego, Michela, Luisa Dupuis, Maria, Ascione, Alessandro, Gellini, Mara, Mallano, Alessandra, Magnani, Mauro

“…Carcinoembryonic antigen–related cell adhesion molecule 1 (CEACAM1) is a cell surface glycoprotein involved in intercellular binding, belonging to the…”
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Functional Role of Glycosylation in a Human IgG4 Antibody Assessed by Surface Plasmon Resonance Technology by B. Wong, Rosie, Zeng, Ming, Lee, An-Horng, Shantha Raju, T., Cheng, Kuang-Chuan

“…Fc glycosylation of immunoglobulins is necessary for antibody effector functions. These glycans of immunoglobulins are often referred as glycoforms and they…”
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Stress-Induced Hyperthermia in Translational Stress Research by H. Vinkers, Christiaan, Penning, Renske, M. Ebbens, Marieke, Hellhammer, Juliane, C. Verste, Joris, J. Kalkman, Cor, Olivier, Berend

“…The stress-induced hyperthermia (SIH) response is the transient change in body temperature in response to acute stress. This body temperature response is part…”
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Primary Sclerosing Cholangitis - Current Issues in Clinical Practice by Corless, L., Tsai, H.

“…Aims: To review current issues in the diagnosis and treatment of primary sclerosing cholangitis. Methods: search of PubMed using the terms “primary sclerosing…”
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Intelligent Systems and the Systematization of Pharmacological Knowledge: Application of the In Vitro Retina Model by Maura Fernandes de Lima, Vera, Airamir Padilha de Castro, Jose, Hanke, Wolfgang

“…In this century, the IT technology will spread intelligent systems based on cameras, sensors and computers across all fields of the human endeavor. The…”
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Stress-Induced Hyperthermia, the Serotonin System and Anxiety by Vinkers, Christiaan H, Olivier, Berend, Bouwknecht, JAdriaan, Groenink, Lucianne, Olivier, Jocelien DA

“…The serotonin (5-HT) system plays a key role in the pathophysiology of psychiatric disorders including mood and anxiety disorders. A role for serotonin in…”
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Attenuation of Drug-Induced Loss of Righting Reflex Response by Pretreatment with a Nitric Oxide Donor by (Al) Wang, Yuhua, M. Quock, Raymond, D. Keegan, Robert

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Evidence for Excitatory and Inhibitory Amino Acids Participation in the Neuropharmacological Activity of Alpha- and Beta-Amyrin Acetate by Viana, Glauce S. de B., Lemos, Telma L.G., Bandeira, Paulo N., Junior, Antonio P.F., Aragao, Gislei F., Carneiro, Lyvia M.V.

“…We evaluated the neuropharmacological profile of acetylated alpha- and beta-amyrin (AcAMY) obtained by the acetylation of the isomeric mixture of alpha- and…”
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Elucidating GABA sub(A and GABA) sub(B) Receptor Functions in Anxiety Using the Stress-Induced Hyperthermia Paradigm: A Review by Vinkers, Christiaan H, Cryan, John F, Olivier, Berend, Groenink, Lucianne

“…Exposure to acute psychological or physical stress increases core body temperature (stress-induced hyperthermia, SIH) which is part of the autonomic stress…”
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Therapeutic Perspectives of Angiotensin-(1-7) in the Treatment of Cardiovascular Disease by Höcht, Christian, Mayer, Marcos, A. Taira, Carlos

“…In the last decade, new biologically active components of the renin-angiotensin system were found. Angiotensin-(1-7) (Ang-(1-7)), a metabolite of angiotensin I…”
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Inhibition of Inflammatory Cytokine Secretion by Plant-Derived Compounds Inuviscolide and Tomentosin: The Role of NFκB and STAT1 by Abrham, Galya, Dovrat, Sara, Bessler, Hanna, Grossman, Shlomo, Uri, Nir, Bergman, Margalit

“…The plant Inula viscosa has been shown to possess many important medicinal benefits, including anti-inflammatory, anti-oxidant, anti-bacterial, and anti-fungal…”
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Elucidating GABAB and GABAB Receptor Functions in Anxiety Using the Stress-Induced Hyperthermia Paradigm: A Review by H. Vinkers, Christiaan, F. Cryan, John, Olivier, Berend, Groenink, Lucianne

“…Exposure to acute psychological or physical stress increases core body temperature (stress-induced hyperthermia, SIH) which is part of the autonomic stress…”
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Effects of LY379268, A Selective Agonist of mGLu2/3 Receptors, on Isolation-Induced Aggression in Male Mice by Francisco Navarro, José, Jesús Luque, María, Martín-López, Mercedes

“…Recent studies indicate that glutamate metabotropic receptors (mGlu) 1 and 5 are involved in the regulation of aggressive behaviour. Brain distribution of…”
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QT Interval Prolongation and Atypical Proarrhythmia: Monomorphic Ventricular Tachycardia with Trimebutine by Schiariti, Michele, Saladini, Angela, Placanica, Attilio, Saolini, Marta, E. Puddu, Paolo

“…A 59-year old woman was admitted at emergency for palpitation and dizziness. Medication history showed trimebutine 450 mg daily, because of meteorism,…”
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Mapping Biopharmaceutical Innovation and Diffusion: How the Second Translational Block (T2) Shapes Drug Diffusion by Cohen, Joshua, Faden, Laura, Getz, Kenneth

“…In the US, there is a vigorous public debate on the merits of biopharmaceutical innovations and their diffusion. There is virtual unanimity about the…”
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Time of Day and Length of Antidepressant Drug Administration Influence Brain-Derived Neurotrophic Factor and TrkB Levels in Rat Brain by Kozisek, Megan E, Qutna, Nidal M, Bylund, David B

“…The expression of brain-derived neurotrophic factor (BDNF) mRNA and protein and its primary receptor, TrkB mRNA shows circadian oscillations in adult rats;…”
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Potential Benefits of Peroxynitrite by Nossaman, Bobby D, Kadowitz, Philip J

“…Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that…”
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HCV and Diabetes Mellitus: Considerations About Effects of Interferon Therapy by Reynaud, Laura, Carleo, Maria A., Talamo, Maria, Borgia, Guglielmo

“…Nowadays HCV-related chronic hepatitis represents one of the main challenge for infectious diseases for many reasons: the dimension of the phenomenon, as…”
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The Foundation of Toxicology’s Dose x Time = Constant Paradigm in Physics by Rozman, Karl K.

“…The relationship dose x time = constant [mg · hr] has been reported in many toxicological experiments during the past 100 years. It was handled as a curiosity…”
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