Search Results - "The journal of applied laboratory medicine"

Precision of a Clinical Metabolomics Profiling Platform for Use in the Identification of Inborn Errors of Metabolism by Ford, Lisa, Kennedy, Adam D, Goodman, Kelli D, Pappan, Kirk L, Evans, Anne M, Miller, Luke A D, Wulff, Jacob E, Wiggs, Bobby R, Lennon, John J, Elsea, Sarah, Toal, Douglas R

“…The application of whole-exome sequencing for the diagnosis of genetic disease has paved the way for systems-based approaches in the clinical laboratory. Here,…”
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The International Consensus on ANA Patterns (ICAP) in 2021-The 6th Workshop and Current Perspectives by Chan, Edward K L, von Mühlen, Carlos A, Fritzler, Marvin J, Damoiseaux, Jan, Infantino, Maria, Klotz, Werner, Satoh, Minoru, Musset, Lucile, García-De La Torre, Ignacio, Carballo, Orlando Gabriel, Herold, Manfred, de Melo Cruvinel, Wilson, Mimori, Tsuneyo, Andrade, Luis E C

“…The establishment of the International Consensus on ANA Patterns (ICAP) in 2014-2015 was welcomed by members of the medical community as a significant…”
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Reproducibility and Variability of Protein Analytes Measured Using a Multiplexed Modified Aptamer Assay by Tin, Adrienne, Yu, Bing, Ma, Jianzhong, Masushita, Kunihiro, Daya, Natalie, Hoogeveen, Ron C, Ballantyne, Christie M, Couper, David, Rebholz, Casey M, Grams, Morgan E, Alonso, Alvaro, Mosley, Thomas, Heiss, Gerardo, Ganz, Peter, Selvin, Elizabeth, Boerwinkle, Eric, Coresh, Josef

“…There is growing interest in the use of multiplexed aptamer-based assays for large-scale proteomic studies. However, the analytic, short- and long-term…”
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Impact of COVID-19 Pandemic on Laboratory Utilization by Durant, Thomas J S, Peaper, David R, Ferguson, David, Schulz, Wade L

“…Coronavirus disease 2019 (COVID-19) was formally characterized as a pandemic on March 11, 2020. Since that time, the COVID-19 pandemic has led to unprecedented…”
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Standard Venipuncture vs a Capillary Blood Collection Device for the Prospective Determination of Abnormal Liver Chemistry by Wickremsinhe, Enaksha, Fantana, Antoniu, Berthier, Erwin, Quist, Brook A, Lopez de Castilla, Diego, Fix, Charles, Chan, Kahlil, Shi, Jing, Walker, Michael G, Kherani, Jennifer F, Knoderer, Holly, Regev, Arie, Harding, James J

“…Abstract Background Abnormal liver function is a common manifestation of human disease and may also occur in approved and investigational medications as…”
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Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications by Bromberg, Jonathan S, Brennan, Daniel C, Poggio, Emilio, Bunnapradist, Suphamai, Langone, Anthony, Sood, Puneet, Matas, Arthur J, Mannon, Roslyn B, Mehta, Shikha, Sharfuddin, Asif, Fischbach, Bernard, Narayanan, Mohanram, Jordan, Stanley C, Cohen, David J, Zaky, Ziad S, Hiller, David, Woodward, Robert N, Grskovic, Marica, Sninsky, John J, Yee, James P, Bloom, Roy D

“…Previous studies have demonstrated that donor-derived cell-free DNA (dd-cfDNA) found in circulating blood of transplant recipients may serve as a noninvasive…”
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Derivation and Performance of Standardized Enhanced Liver Fibrosis (ELF) Test Thresholds for the Detection and Prognosis of Liver Fibrosis by Day, James, Patel, Preya, Parkes, Julie, Rosenberg, William

“…Abstract Introduction Noninvasive tests are increasingly used to assess liver fibrosis and determine prognosis but suggested test thresholds vary. We describe…”
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Novel Methods for the Quantification of Dipeptidyl Peptidase 3 (DPP3) Concentration and Activity in Human Blood Samples by Rehfeld, Linda, Funk, Eugenia, Jha, Shalinee, Macheroux, Peter, Melander, Olle, Bergmann, Andreas

“…Abstract Background The ubiquitously expressed dipeptidyl peptidase 3 (DPP3) is involved in protein metabolism, blood pressure regulation, and pain modulation…”
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AACC/NKF Guidance Document on Improving Equity in Chronic Kidney Disease Care by Pierre, Christina C, Marzinke, Mark A, Ahmed, Sofia B, Collister, David, Colón-Franco, Jessica M, Hoenig, Melanie P, Lorey, Thomas, Palevsky, Paul M, Palmer, Octavia Peck, Rosas, Sylvia E, Vassalotti, Joseph, Whitley, Cameron T, Greene, Dina N

“…Abstract Background Kidney disease (KD) is an important health equity issue with Black, Hispanic, and socioeconomically disadvantaged individuals experiencing…”
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Clinical Sensitivity, Specificity, and Predictive Value of Neural Antibody Testing for Autoimmune Encephalitis by Budhram, Adrian, Yang, Liju, Bhayana, Vipin, Mills, John R, Dubey, Divyanshu

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AACC Guidance Document on Biotin Interference in Laboratory Tests by Li, Danni, Ferguson, Angela, Cervinski, Mark A, Lynch, Kara L, Kyle, Patrick B

“…Laboratory tests that use streptavidin-biotin binding mechanisms have the potential to be affected by high circulating biotin concentrations, which would…”
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Vitamin C Status of US Adults Assessed as Part of the National Health and Nutrition Examination Survey Remained Unchanged between 2003–2006 and 2017–2018 by Powers, Carissa D, Sternberg, Maya R, Patel, Sweta B, Pfeiffer, Christine M, Storandt, Renee J, Schleicher, Rosemary L

“…Abstract Background We compared serum vitamin C (VIC) status of the adult (≥20 y) US population in the National Health and Nutrition Examination Survey…”
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Advances in Rapid Molecular Blood Culture Diagnostics: Healthcare Impact, Laboratory Implications, and Multiplex Technologies by She, Rosemary C, Bender, Jeffrey M

“…Abstract Background For far too long, the diagnosis of bloodstream infections has relied on time-consuming blood cultures coupled with traditional organism…”
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Intraoperative Mass Spectrometry Platform for IDH Mutation Status Prediction, Glioma Diagnosis, and Estimation of Tumor Cell Infiltration by Brown, Hannah Marie, Alfaro, Clint M, Pirro, Valentina, Dey, Mahua, Hattab, Eyas M, Cohen-Gadol, Aaron A, Cooks, R Graham

“…Surgical tumor resection is the primary treatment option for diffuse glioma, the most common malignant brain cancer. The intraoperative diagnosis of gliomas…”
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Comprehensive Pediatric Reference Limits for High-Sensitivity Cardiac Troponin I and NT-proBNP in the CALIPER Cohort by Bohn, Mary Kathryn, Adeli, Khosrow

“…Abstract Background Cardiac biomarkers have increasing application in pediatric populations, including congenital heart disease, myocarditis, and heart…”
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Biotin Interference in Clinical Immunoassays by Colon, Paula Jenkins, Greene, Dina N

“…Shifts in consumer behavior and clinical practice have increased reports of biotin interference in immunoassays that incorporate biotin-streptavidin linkages…”
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Head-to-Head Comparison of Two SARS-CoV-2 Serology Assays by Merrill, Anna E, Jackson, J Brooks, Ehlers, Alexandra, Voss, Dena, Krasowski, Matthew D

“…While molecular techniques remain the gold standard for diagnosis of acute SARS-CoV-2 infection, serological tests have the unique potential to ascertain how…”
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Screening for Primary Aldosteronism by Mass Spectrometry Versus Immunoassay Measurements of Aldosterone: A Prospective Within-Patient Study by Fuld, Sybille, Constantinescu, Georgiana, Pamporaki, Christina, Peitzsch, Mirko, Schulze, Manuel, Yang, Jun, Müller, Lisa, Prejbisz, Aleksander, Januszewicz, Andrzej, Remde, Hanna, Kürzinger, Lydia, Dischinger, Ulrich, Ernst, Matthias, Gruber, Sven, Reincke, Martin, Beuschlein, Felix, Lenders, Jacques W M, Eisenhofer, Graeme

“…Measurements of aldosterone by mass spectrometry are more accurate and less prone to interferences than immunoassay measurements, and may produce a more…”
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Laboratory Tests and Outcome for Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis by Alnor, Anne, Sandberg, Maria B, Gils, Charlotte, Vinholt, Pernille J

“…Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 2019 (COVID-19) and poses substantial challenges for healthcare systems. With a…”
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Point-of-Care Therapeutic Drug Monitoring for Precision Dosing of Immunosuppressive Drugs by Taddeo, Adriano, Prim, Denis, Bojescu, Elena-Diana, Segura, Jean-Manuel, Pfeifer, Marc E

“…Abstract Background Immunosuppressive drugs (ISD) are an essential tool in the treatment of transplant rejection and immune-mediated diseases. Therapeutic drug…”
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