Search Results - "The Journal of physiology"

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers by Burke, Louise M., Ross, Megan L., Garvican‐Lewis, Laura A., Welvaert, Marijke, Heikura, Ida A., Forbes, Sara G., Mirtschin, Joanne G., Cato, Louise E., Strobel, Nicki, Sharma, Avish P., Hawley, John A.

“…Key points Three weeks of intensified training and mild energy deficit in elite race walkers increases peak aerobic capacity independent of dietary support…”
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Lactate in contemporary biology: a phoenix risen by Brooks, George A., Arevalo, Jose A., Osmond, Adam D., Leija, Robert G., Curl, Casey C., Tovar, Ashley P.

“…After a century, it's time to turn the page on understanding of lactate metabolism and appreciate that lactate shuttling is an important component of…”
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Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: a stable isotope study by Boets, Eef, Gomand, Sara V., Deroover, Lise, Preston, Tom, Vermeulen, Karen, Preter, Vicky, Hamer, Henrike M., den Mooter, Guy, Vuyst, Luc, Courtin, Christophe M., Annaert, Pieter, Delcour, Jan A., Verbeke, Kristin A.

“…Key points The short‐chain fatty acids (SCFAs) are bacterial metabolites produced during the colonic fermentation of undigested carbohydrates, such as dietary…”
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Human circadian phase–response curves for exercise by Youngstedt, Shawn D., Elliott, Jeffrey A., Kripke, Daniel F.

“…Key points Exercise elicits circadian phase‐shifting effects, but additional information is needed. The phase–response curve describing the magnitude and…”
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Endothelial cell–cardiomyocyte crosstalk in heart development and disease by Colliva, Andrea, Braga, Luca, Giacca, Mauro, Zacchigna, Serena

“…The crosstalk between endothelial cells and cardiomyocytes has emerged as a requisite for normal cardiac development, but also a key pathogenic player during…”
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HIITing the brain with exercise: mechanisms, consequences and practical recommendations by Calverley, Thomas A., Ogoh, Shigehiko, Marley, Christopher J., Steggall, Martin, Marchi, Nicola, Brassard, Patrice, Lucas, Samuel J.E., Cotter, James D., Roig, Marc, Ainslie, Philip N., Wisløff, Ulrik, Bailey, Damian M.

“…The increasing number of older adults has seen a corresponding growth in those affected by neurovascular diseases, including stroke and dementia. Since cures…”
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Synchronization and desynchronization in epilepsy: controversies and hypotheses by Jiruska, Premysl, de Curtis, Marco, Jefferys, John G. R., Schevon, Catherine A., Schiff, Steven J., Schindler, Kaspar

“…Epilepsy has been historically seen as a functional brain disorder associated with excessive synchronization of large neuronal populations leading to a…”
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Neuromuscular electrical stimulation‐promoted plasticity of the human brain by Carson, Richard G., Buick, Alison R.

“…The application of neuromuscular electrical stimulation (NMES) to paretic limbs has demonstrated utility for motor rehabilitation following brain injury. When…”
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Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans by Monti, Elena, Reggiani, Carlo, Franchi, Martino V., Toniolo, Luana, Sandri, Marco, Armani, Andrea, Zampieri, Sandra, Giacomello, Emiliana, Sarto, Fabio, Sirago, Giuseppe, Murgia, Marta, Nogara, Leonardo, Marcucci, Lorenzo, Ciciliot, Stefano, Šimunic, Boštjan, Pišot, Rado, Narici, Marco V.

“…Key points Few days of unloading are sufficient to induce a decline of skeletal muscle mass and function; notably, contractile force is lost at a faster rate…”
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A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources by Kernik, Divya C., Morotti, Stefano, Wu, HaoDi, Garg, Priyanka, Duff, Henry J., Kurokawa, Junko, Jalife, José, Wu, Joseph C., Grandi, Eleonora, Clancy, Colleen E.

“…Key points Induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) capture patient‐specific genotype–phenotype relationships, as well as cell‐to‐cell…”
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Effects of leucine and its metabolite [beta]-hydroxy-[beta]-methylbutyrate on human skeletal muscle protein metabolism by Wilkinson, D J, Hossain, T, Hill, D S, Phillips, B E, Crossland, H, Williams, J, Loughna, P, Churchward-Venne, T A, Breen, L, Phillips, S M, Etheridge, T, Rathmacher, J A, Smith, K, Szewczyk, N J, Atherton, P J

“…Key points * The branched-chain amino acid (BCAA) leucine acts as both a 'trigger' for the initiation of protein synthesis, and as a substrate for newly…”
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Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non‐sarcopenic older men by Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D. W., Swiecicka, A., Rutter, M. K., Jones, D. A., McPhee, J. S.

“…Key points The age‐related loss of muscle mass is related to the loss of innervating motor neurons and denervation of muscle fibres. Not all denervated muscle…”
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Silent hypoxaemia in COVID‐19 patients by Simonson, Tatum S., Baker, Tracy L., Banzett, Robert B., Bishop, Tammie, Dempsey, Jerome A., Feldman, Jack L., Guyenet, Patrice G., Hodson, Emma J., Mitchell, Gordon S., Moya, Esteban A., Nokes, Brandon T., Orr, Jeremy E., Owens, Robert L., Poulin, Marc, Rawling, Jean M., Schmickl, Christopher N., Watters, Jyoti J., Younes, Magdy, Malhotra, Atul

“…The clinical presentation of COVID‐19 due to infection with SARS‐CoV‐2 is highly variable with the majority of patients having mild symptoms while others…”
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Synchronous deficits in cumulative muscle protein synthesis and ribosomal biogenesis underlie age‐related anabolic resistance to exercise in humans by Brook, Matthew S., Wilkinson, Daniel J., Mitchell, William K., Lund, Jonathan N., Phillips, Bethan E., Szewczyk, Nathaniel J., Greenhaff, Paul L., Smith, Kenneth, Atherton, Philip J.

“…Key points Resistance exercise training (RET) is one of the most effective strategies for preventing declines in skeletal muscle mass and strength with age…”
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A neural circuitry that emphasizes spinal feedback generates diverse behaviours of human locomotion by Song, Seungmoon, Geyer, Hartmut

“…Key points It is often assumed that central pattern generators, which generate rhythmic patterns without rhythmic inputs, play a key role in the spinal control…”
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Sex differences in fatigability and recovery relative to the intensity–duration relationship by Ansdell, Paul, Brownstein, Callum G., Škarabot, Jakob, Hicks, Kirsty M., Howatson, Glyn, Thomas, Kevin, Hunter, Sandra K., Goodall, Stuart

“…Key points Females demonstrate greater fatigue resistance than males during contractions at intensities relative to maximum force. However, previous studies…”
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Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic by Morrison, Janna L., Botting, Kimberley J., Darby, Jack R. T., David, Anna L., Dyson, Rebecca M., Gatford, Kathryn L., Gray, Clint, Herrera, Emilio A., Hirst, Jonathan J., Kim, Bona, Kind, Karen L., Krause, Bernardo J., Matthews, Stephen G., Palliser, Hannah K., Regnault, Timothy R. H., Richardson, Bryan S., Sasaki, Aya, Thompson, Loren P., Berry, Mary J.

“…Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non‐communicable disease in…”
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Tracking motor units longitudinally across experimental sessions with high‐density surface electromyography by Martinez‐Valdes, E., Negro, F., Laine, C. M., Falla, D., Mayer, F., Farina, D.

“…Key points Classic motor unit (MU) recording and analysis methods do not allow the same MUs to be tracked across different experimental sessions, and…”
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Uncertainty and variability in computational and mathematical models of cardiac physiology by Mirams, Gary R., Pathmanathan, Pras, Gray, Richard A., Challenor, Peter, Clayton, Richard H.

“…Key points Mathematical and computational models of cardiac physiology have been an integral component of cardiac electrophysiology since its inception, and…”
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Exosome engineering for efficient and targeted drug delivery: Current status and future perspective by Malekian, Farzaneh, Shamsian, Alireza, Kodam, Sai Priyanka, Ullah, Mujib

“…Exosomes are membrane-bound vesicles that are released by most cells. They carry nucleic acids, cytokines, growth factors, proteins, lipids, and metabolites…”
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