Search Results - "The Journal of pharmacology and experimental therapeutics"

Oxidative Stress and the Central Nervous System by Salim, Samina

“…Biochemical integrity of the brain is vital for normal functioning of the central nervous system (CNS). One of the factors contributing to cerebral biochemical…”
Get more information

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile by Barf, Tjeerd, Covey, Todd, Izumi, Raquel, van de Kar, Bas, Gulrajani, Michael, van Lith, Bart, van Hoek, Maaike, de Zwart, Edwin, Mittag, Diana, Demont, Dennis, Verkaik, Saskia, Krantz, Fanny, Pearson, Paul G, Ulrich, Roger, Kaptein, Allard

“…Several small-molecule Bruton tyrosine kinase (BTK) inhibitors are in development for B cell malignancies and autoimmune disorders, each characterized by…”
Get more information

RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies by Traber, Gavin M, Yu, Ai-Ming

“…RNA interference (RNAi) provides researchers with a versatile means to modulate target gene expression. The major forms of RNAi molecules, genome-derived…”
Get full text

Nose-to-Brain Delivery by Wang, Zian, Xiong, Guojun, Tsang, Wai Chun, Schätzlein, Andreas G, Uchegbu, Ijeoma F

“…The global prevalence of neurologic disorders is rising, and yet we are still unable to deliver most drug molecules, in therapeutic quantities, to the brain…”
Get more information

The Pharmacological Case for Cannabigerol by Nachnani, Rahul, Raup-Konsavage, Wesley M, Vrana, Kent E

“…Medical cannabis and individual cannabinoids, such as Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD), are receiving growing attention in both the media…”
Get full text

Antidepressant Potential of ( R )-Ketamine in Rodent Models: Comparison with ( S )-Ketamine by Fukumoto, Kenichi, Toki, Hidetoh, Iijima, Michihiko, Hashihayata, Takashi, Yamaguchi, Jun-Ichi, Hashimoto, Kenji, Chaki, Shigeyuki

“…The rapid-acting and long-lasting antidepressant effects of ( )-ketamine have recently gained much attention. Although ( )-ketamine has been studied as an…”
Get more information

Microneedle Coating Methods: A Review with a Perspective by Ingrole, Rohan S J, Gill, Harvinder Singh

“…A coated microneedle array comprises sharp micrometer-sized needle shafts attached to a base substrate and coated with a drug on their surfaces. Coated…”
Get more information

Inhibiting MicroRNA-29a Protects Myocardial Ischemia-Reperfusion Injury by Targeting SIRT1 and Suppressing Oxidative Stress and NLRP3-Mediated Pyroptosis Pathway by Ding, Shoukun, Liu, Donghai, Wang, Lixia, Wang, Guanggong, Zhu, Yaobin

“…To investigate the effects of microRNA-29a (miR-29a) on myocardial ischemia-reperfusion (I/R) injury and its specific mechanisms, we used H9C2 myocardial cells…”
Get full text

Drug Discovery Strategies for SARS-CoV-2 by Shyr, Zeenat A, Gorshkov, Kirill, Chen, Catherine Z, Zheng, Wei

“…Coronavirus disease 2019 (COVID-19) is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected…”
Get full text

Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis by Torralva, Randy, Janowsky, Aaron

“…In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in America. Opioid overdose is the single greatest cause of death in the…”
Get more information

Mitochondrial dysfunction in neurodegenerative diseases by Johri, Ashu, Beal, M Flint

“…Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes…”
Get more information

Pharmacokinetic and Pharmacodynamic Properties of Drug Delivery Systems by Glassman, Patrick M, Muzykantov, Vladimir R

“…The use of drug delivery systems (DDS) is an attractive approach to facilitate uptake of therapeutic agents at the desired site of action, particularly when…”
Get more information

Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia by Cotticelli, M Grazia, Xia, Shujuan, Lin, Daniel, Lee, Taehee, Terrab, Leila, Wipf, Peter, Huryn, Donna M, Wilson, Robert B

“…Friedreich ataxia (FRDA) is a progressive neuro- and cardio-degenerative disorder characterized by ataxia, sensory loss, and hypertrophic cardiomyopathy. In…”
Get more information

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ -Opioid Receptor and Opioid-Like Behavioral Effects in Rats by Obeng, Samuel, Wilkerson, Jenny L, León, Francisco, Reeves, Morgan E, Restrepo, Luis F, Gamez-Jimenez, Lea R, Patel, Avi, Pennington, Anna E, Taylor, Victoria A, Ho, Nicholas P, Braun, Tobias, Fortner, John D, Crowley, Morgan L, Williamson, Morgan R, Pallares, Victoria L C, Mottinelli, Marco, Lopera-Londoño, Carolina, McCurdy, Christopher R, McMahon, Lance R, Hiranita, Takato

“…Relationships between -opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro…”
Get full text

MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition by Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of familial and sporadic Parkinson's disease (PD). That the most…”
Get more information

Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor by Shi, Licheng, Lehto, Sonya G, Zhu, Dawn X D, Sun, Hong, Zhang, Jianhua, Smith, Brian P, Immke, David C, Wild, Kenneth D, Xu, Cen

“…Therapeutic agents that block the calcitonin gene-related peptide (CGRP) signaling pathway are a highly anticipated and promising new drug class for migraine…”
Get more information

Rationale for poly(ADP-ribose) polymerase (PARP) inhibitors in combination therapy with camptothecins or temozolomide based on PARP trapping versus catalytic inhibition by Murai, Junko, Zhang, Yiping, Morris, Joel, Ji, Jiuping, Takeda, Shunichi, Doroshow, James H, Pommier, Yves

“…We recently showed that poly(ADP-ribose) polymerase (PARP) inhibitors exert their cytotoxicity primarily by trapping PARP-DNA complexes in addition to their…”
Get more information

Functions of galectin-3 and its role in fibrotic diseases by Li, Liu-cheng, Li, Jun, Gao, Jian

“…Fibrotic diseases occur in a variety of organs and lead to continuous organ injury, function decline, and even failure. Currently effective treatment options…”
Get more information

Protoporphyrin IX: the Good, the Bad, and the Ugly by Sachar, Madhav, Anderson, Karl E, Ma, Xiaochao

“…Protoporphyrin IX (PPIX) is ubiquitously present in all living cells in small amounts as a precursor of heme. PPIX has some biologic functions of its own, and…”
Get more information

Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates by Rigo, Frank, Chun, Seung J, Norris, Daniel A, Hung, Gene, Lee, Sam, Matson, John, Fey, Robert A, Gaus, Hans, Hua, Yimin, Grundy, John S, Krainer, Adrian R, Henry, Scott P, Bennett, C Frank

“…Spinal muscular atrophy (SMA) is a debilitating neuromuscular disease caused by the loss of survival of motor neuron (SMN) protein. Previously, we demonstrated…”
Get more information