Search Results - "The Journal of pathology"

Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19) by Bourgonje, Arno R, Abdulle, Amaal E, Timens, Wim, Hillebrands, Jan‐Luuk, Navis, Gerjan J, Gordijn, Sanne J, Bolling, Marieke C, Dijkstra, Gerard, Voors, Adriaan A, Osterhaus, Albert DME, Voort, Peter HJ, Mulder, Douwe J, Goor, Harry

“…Angiotensin‐converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2),…”
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Interpretation of somatic POLE mutations in endometrial carcinoma by León‐Castillo, Alicia, Britton, Heidi, McConechy, Melissa K, McAlpine, Jessica N, Nout, Remi, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Bosse, Tjalling, Church, David N, Gilks, C Blake

“…Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE) exonuclease domain define the important subtype of ultramutated tumours…”
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Clinicopathological and molecular characterisation of ‘multiple‐classifier’ endometrial carcinomas by León‐Castillo, Alicia, Gilvazquez, Ester, Nout, Remi, Smit, Vincent THBM, McAlpine, Jessica N, McConechy, Melissa, Kommoss, Stefan, Brucker, Sara Y, Carlson, Joseph W, Epstein, Elisabeth, Rau, Tilman T, Soslow, Robert A, Ganesan, Raji, Matias‐Guiu, Xavier, Oliva, Esther, Harrison, Beth T, Church, David N, Gilks, C Blake, Bosse, Tjalling

“…Endometrial carcinoma (EC) molecular classification based on four molecular subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance in…”
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p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies by Singh, Naveena, Piskorz, Anna M, Bosse, Tjalling, Jimenez‐Linan, Mercedes, Rous, Brian, Brenton, James D, Gilks, C Blake, Köbel, Martin

“…TP53 mutations are considered a surrogate biomarker of the serous‐like ‘copy number high’ molecular subtype of endometrial carcinoma (EC). In ovarian…”
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Artificial intelligence in digital pathology: a roadmap to routine use in clinical practice by Colling, Richard, Pitman, Helen, Oien, Karin, Rajpoot, Nasir, Macklin, Philip, Bachtiar, Velicia, Booth, Richard, Bryant, Alyson, Bull, Joshua, Bury, Jonathan, Carragher, Fiona, Colling, Richard, Collins, Graeme, Craig, Clare, da Silva, Maria Freitas, Gosling, Daniel, Jacobs, Jaco, Kajland‐Wilén, Lena, Karling, Johanna, Lawler, Darragh, Lee, Stephen, Macklin, Philip, Miller, Keith, Mozolowski, Guy, Nicholson, Richard, O'Connor, Daniel, Rahbek, Mikkel, Rajpoot, Nasir, Sumner, Alan, Vossen, Dirk, White, Kieron, Wing, Charlotte, Wright, Corrina, Snead, David, Sackville, Tony, Verrill, Clare

“…The use of artificial intelligence will transform clinical practice over the next decade and the early impact of this will likely be the integration of image…”
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Motile and non‐motile cilia in human pathology: from function to phenotypes by Mitchison, Hannah M, Valente, Enza Maria

“…Ciliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease…”
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Macrophage plasticity and polarization in tissue repair and remodelling by Mantovani, Alberto, Biswas, Subhra K, Galdiero, Maria Rosaria, Sica, Antonio, Locati, Massimo

“…Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly…”
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Neutrophils in the initiation and resolution of acute pulmonary inflammation: understanding biological function and therapeutic potential by Potey, Philippe MD, Rossi, Adriano G, Lucas, Christopher D, Dorward, David A

“…Acute respiratory distress syndrome (ARDS) is the often fatal sequelae of a broad range of precipitating conditions. Despite decades of intensive research and…”
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YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation by Hasegawa, Kana, Fujii, Shinsuke, Matsumoto, Shinji, Tajiri, Yudai, Kikuchi, Akira, Kiyoshima, Tamotsu

“…Most cancer cells are exposed to altered extracellular environments, such as an increase in extracellular matrix (ECM) stiffness and soluble signals consisting…”
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Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis by Conlon, Guy A, Murray, Graeme I

“…This review aims to provide an overview of recent developments regarding the roles of MMPs in tumour invasion and metastasis. Much of the mortality burden…”
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A streamlined mass spectrometry–based proteomics workflow for large‐scale FFPE tissue analysis by Coscia, Fabian, Doll, Sophia, Bech, Jacob Mathias, Schweizer, Lisa, Mund, Andreas, Lengyel, Ernst, Lindebjerg, Jan, Madsen, Gunvor Iben, Moreira, José MA, Mann, Matthias

“…Formalin fixation and paraffin‐embedding (FFPE) is the most common method to preserve human tissue for clinical diagnosis, and FFPE archives represent an…”
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Molecular pathology of Lynch syndrome by Cerretelli, Guia, Ager, Ann, Arends, Mark J, Frayling, Ian M

“…Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other cancers and is caused by inherited pathogenic variants affecting…”
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MAPK pathway activity plays a key role in PD‐L1 expression of lung adenocarcinoma cells by Stutvoet, Thijs S, Kol, Arjan, Vries, Elisabeth GE, Bruyn, Marco, Fehrmann, Rudolf SN, Terwisscha van Scheltinga, Anton GT, Jong, Steven

“…Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD‐1) and programmed death‐ligand 1 (PD‐L1) have improved the survival of patients with…”
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Synthesis of diagnostic quality cancer pathology images by generative adversarial networks by Levine, Adrian B, Peng, Jason, Farnell, David, Nursey, Mitchell, Wang, Yiping, Naso, Julia R, Ren, Hezhen, Farahani, Hossein, Chen, Colin, Chiu, Derek, Talhouk, Aline, Sheffield, Brandon, Riazy, Maziar, Ip, Philip P, Parra‐Herran, Carlos, Mills, Anne, Singh, Naveena, Tessier‐Cloutier, Basile, Salisbury, Taylor, Lee, Jonathan, Salcudean, Tim, Jones, Steven JM, Huntsman, David G, Gilks, C Blake, Yip, Stephen, Bashashati, Ali

“…Deep learning‐based computer vision methods have recently made remarkable breakthroughs in the analysis and classification of cancer pathology images. However,…”
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Exosomal miR-24-3p impedes T-cell function by targeting FGF11 and serves as a potential prognostic biomarker for nasopharyngeal carcinoma by Ye, Shu-Biao, Zhang, Han, Cai, Ting-Ting, Liu, Yi-Na, Ni, Jian-Jiao, He, Jia, Peng, Jing-Yun, Chen, Qiu-Yan, Mo, Hao-Yuan, Jun-Cui, Zhang, Xiao-Shi, Zeng, Yi-Xin, Li, Jiang

“…Recent studies have shown that extracellular microRNAs are not only potential biomarkers but are also involved in cell interactions to regulate the…”
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Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression by Wang, Jinheng, De Veirman, Kim, Faict, Sylvia, Frassanito, Maria Antonia, Ribatti, Domenico, Vacca, Angelo, Menu, Eline

“…Multiple myeloma (MM) pathogenesis and progression largely rely on the cells and extracellular factors in the bone marrow (BM) microenvironment. Compelling…”
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Multispectral imaging for quantitative and compartment‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients by Mezheyeuski, Artur, Bergsland, Christian Holst, Backman, Max, Djureinovic, Dijana, Sjöblom, Tobias, Bruun, Jarle, Micke, Patrick

“…Semiquantitative assessment of immune markers by immunohistochemistry (IHC) has significant limitations for describing the diversity of the immune response in…”
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The role of Epstein-Barr virus in epithelial malignancies by Tsao, Sai-Wah, Tsang, Chi Man, To, Ka-Fai, Lo, Kwok-Wai

“…The close association of Epstein–Barr virus (EBV) infection with non‐keratinizing nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that…”
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HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials by Richman, Susan D, Southward, Katie, Chambers, Philip, Cross, Debra, Barrett, Jennifer, Hemmings, Gemma, Taylor, Morag, Wood, Henry, Hutchins, Gordon, Foster, Joseph M, Oumie, Assa, Spink, Karen G, Brown, Sarah R, Jones, Marc, Kerr, David, Handley, Kelly, Gray, Richard, Seymour, Matthew, Quirke, Philip

“…HER2 overexpression/amplification is linked to trastuzumab response in breast/gastric cancers. One suggested anti‐EGFR resistance mechanism in colorectal…”
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Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis by Brown, Gordon T, Murray, Graeme I

“…The purpose of this review is to highlight the recent mechanistic developments elucidating the role of matrix metalloproteinases (MMPs) in tumour invasion and…”
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