Search Results - "The Journal of clinical investigation"

Mitochondrial dysfunction in cell senescence and aging by Miwa, Satomi, Kashyap, Sonu, Chini, Eduardo, von Zglinicki, Thomas

“…Mitochondrial dysfunction and cell senescence are hallmarks of aging and are closely interconnected. Mitochondrial dysfunction, operationally defined as a…”
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Immune responses to stroke: mechanisms, modulation, and therapeutic potential by Iadecola, Costantino, Buckwalter, Marion S, Anrather, Josef

“…Stroke is the second leading cause of death worldwide and a leading cause of disability. Most strokes are caused by occlusion of a major cerebral artery, and…”
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Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators by Serhan, Charles N, Levy, Bruce D

“…Countless times each day, the acute inflammatory response protects us from invading microbes, injuries, and insults from within, as in surgery-induced tissue…”
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B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma by Cohen, Adam D, Garfall, Alfred L, Stadtmauer, Edward A, Melenhorst, J Joseph, Lacey, Simon F, Lancaster, Eric, Vogl, Dan T, Weiss, Brendan M, Dengel, Karen, Nelson, Annemarie, Plesa, Gabriela, Chen, Fang, Davis, Megan M, Hwang, Wei-Ting, Young, Regina M, Brogdon, Jennifer L, Isaacs, Randi, Pruteanu-Malinici, Iulian, Siegel, Don L, Levine, Bruce L, June, Carl H, Milone, Michael C

“…Chimeric antigen receptor (CAR) T cells are a promising therapy for hematologic malignancies. B-cell maturation antigen (BCMA) is a rational target in multiple…”
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The gut microbiome and metabolic syndrome by Dabke, Kruttika, Hendrick, Gustaf, Devkota, Suzanne

“…The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will often progress to greater metabolic defects such as type 2…”
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Cellular senescence: a key therapeutic target in aging and diseases by Zhang, Lei, Pitcher, Louise E, Yousefzadeh, Matthew J, Niedernhofer, Laura J, Robbins, Paul D, Zhu, Yi

“…Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can…”
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CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients by Turtle, Cameron J, Hanafi, Laïla-Aïcha, Berger, Carolina, Gooley, Theodore A, Cherian, Sindhu, Hudecek, Michael, Sommermeyer, Daniel, Melville, Katherine, Pender, Barbara, Budiarto, Tanya M, Robinson, Emily, Steevens, Natalia N, Chaney, Colette, Soma, Lorinda, Chen, Xueyan, Yeung, Cecilia, Wood, Brent, Li, Daniel, Cao, Jianhong, Heimfeld, Shelly, Jensen, Michael C, Riddell, Stanley R, Maloney, David G

“…T cells that have been modified to express a CD19-specific chimeric antigen receptor (CAR) have antitumor activity in B cell malignancies; however,…”
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mRNA vaccine-induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer by Cafri, Gal, Gartner, Jared J, Zaks, Tal, Hopson, Kristen, Levin, Noam, Paria, Biman C, Parkhurst, Maria R, Yossef, Rami, Lowery, Frank J, Jafferji, Mohammad S, Prickett, Todd D, Goff, Stephanie L, McGowan, Christine T, Seitter, Samantha, Shindorf, Mackenzie L, Parikh, Anup, Chatani, Praveen D, Robbins, Paul F, Rosenberg, Steven A

“…BACKGROUNDTherapeutic vaccinations against cancer have mainly targeted differentiation antigens, cancer-testis antigens, and overexpressed antigens and have…”
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Liver inflammation and fibrosis by Koyama, Yukinori, Brenner, David A

“…Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component…”
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Microglia in Alzheimer's disease by Sarlus, Heela, Heneka, Michael T

“…Microglia are brain-resident myeloid cells that mediate key functions to support the CNS. Microglia express a wide range of receptors that act as molecular…”
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Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells by Oh, Min-Hee, Sun, Im-Hong, Zhao, Liang, Leone, Robert D, Sun, Im-Meng, Xu, Wei, Collins, Samuel L, Tam, Ada J, Blosser, Richard L, Patel, Chirag H, Englert, Judson M, Arwood, Matthew L, Wen, Jiayu, Chan-Li, Yee, Tenora, Lukáš, Majer, Pavel, Rais, Rana, Slusher, Barbara S, Horton, Maureen R, Powell, Jonathan D

“…Myeloid cells comprise a major component of the tumor microenvironment (TME) that promotes tumor growth and immune evasion. By employing a small-molecule…”
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Neutrophil extracellular traps regulate ischemic stroke brain injury by Denorme, Frederik, Portier, Irina, Rustad, John L, Cody, Mark J, de Araujo, Claudia V, Hoki, Chieko, Alexander, Matthew D, Grandhi, Ramesh, Dyer, Mitchell R, Neal, Matthew D, Majersik, Jennifer J, Yost, Christian C, Campbell, Robert A

“…Ischemic stroke prompts a strong inflammatory response, which is associated with exacerbated outcomes. In this study, we investigated mechanistic regulators of…”
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Next-generation sequencing: insights to advance clinical investigations of the microbiome by Wensel, Caroline R, Pluznick, Jennifer L, Salzberg, Steven L, Sears, Cynthia L

“…Next-generation sequencing (NGS) technology has advanced our understanding of the human microbiome by allowing for the discovery and characterization of…”
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Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine by Beharier, Ofer, Plitman Mayo, Romina, Raz, Tal, Nahum Sacks, Kira, Schreiber, Letizia, Suissa-Cohen, Yael, Chen, Rony, Gomez-Tolub, Rachel, Hadar, Eran, Gabbay-Benziv, Rinat, Jaffe Moshkovich, Yuval, Biron-Shental, Tal, Shechter-Maor, Gil, Farladansky-Gershnabel, Sivan, Yitzhak Sela, Hen, Benyamini-Raischer, Hedi, Sela, Nitzan D, Goldman-Wohl, Debra, Shulman, Ziv, Many, Ariel, Barr, Haim, Yagel, Simcha, Neeman, Michal, Kovo, Michal

“…The significant risks posed to mothers and fetuses by COVID-19 in pregnancy have sparked a worldwide debate surrounding the pros and cons of antenatal…”
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Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease by Roy, Ethan R, Wang, Baiping, Wan, Ying-Wooi, Chiu, Gabriel, Cole, Allysa, Yin, Zhuoran, Propson, Nicholas E, Xu, Yin, Jankowsky, Joanna L, Liu, Zhandong, Lee, Virginia M-Y, Trojanowski, John Q, Ginsberg, Stephen D, Butovsky, Oleg, Zheng, Hui, Cao, Wei

“…Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we demonstrated a potent IFN immunogenicity of nucleic…”
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Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition by Cherkassky, Leonid, Morello, Aurore, Villena-Vargas, Jonathan, Feng, Yang, Dimitrov, Dimiter S, Jones, David R, Sadelain, Michel, Adusumilli, Prasad S

“…Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive resistance compromises the…”
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PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression by Tang, Haidong, Liang, Yong, Anders, Robert A, Taube, Janis M, Qiu, Xiangyan, Mulgaonkar, Aditi, Liu, Xin, Harrington, Susan M, Guo, Jingya, Xin, Yangchun, Xiong, Yahong, Nham, Kien, Silvers, William, Hao, Guiyang, Sun, Xiankai, Chen, Mingyi, Hannan, Raquibul, Qiao, Jian, Dong, Haidong, Peng, Hua, Fu, Yang-Xin

“…Programmed death-ligand 1 (PD-L1) expression on tumor cells is essential for T cell impairment, and PD-L1 blockade therapy has shown unprecedented durable…”
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Baricitinib restrains the immune dysregulation in patients with severe COVID-19 by Bronte, Vincenzo, Ugel, Stefano, Tinazzi, Elisa, Vella, Antonio, De Sanctis, Francesco, Canè, Stefania, Batani, Veronica, Trovato, Rosalinda, Fiore, Alessandra, Petrova, Varvara, Hofer, Francesca, Barouni, Roza Maria, Musiu, Chiara, Caligola, Simone, Pinton, Laura, Torroni, Lorena, Polati, Enrico, Donadello, Katia, Friso, Simonetta, Pizzolo, Francesca, Iezzi, Manuela, Facciotti, Federica, Pelicci, Pier Giuseppe, Righetti, Daniela, Bazzoni, Paolo, Rampudda, Mariaelisa, Comel, Andrea, Mosaner, Walter, Lunardi, Claudio, Olivieri, Oliviero

“…BACKGROUNDPatients with coronavirus disease 2019 (COVID-19) develop pneumonia generally associated with lymphopenia and a severe inflammatory response due to…”
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Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier by Yonker, Lael M, Gilboa, Tal, Ogata, Alana F, Senussi, Yasmeen, Lazarovits, Roey, Boribong, Brittany P, Bartsch, Yannic C, Loiselle, Maggie, Rivas, Magali Noval, Porritt, Rebecca A, Lima, Rosiane, Davis, Jameson P, Farkas, Eva J, Burns, Madeleine D, Young, Nicola, Mahajan, Vinay S, Hajizadeh, Soroush, Lopez, Xcanda I Herrera, Kreuzer, Johannes, Morris, Robert, Martinez, Enid E, Han, Isaac, Griswold, Jr, Kettner, Barry, Nicholas C, Thompson, David B, Church, George, Edlow, Andrea G, Haas, Wilhelm, Pillai, Shiv, Arditi, Moshe, Alter, Galit, Walt, David R, Fasano, Alessio

“…BACKGROUNDWeeks after SARS-CoV-2 infection or exposure, some children develop a severe, life-threatening illness called multisystem inflammatory syndrome in…”
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Targeting noncoding RNAs in disease by Adams, Brian D, Parsons, Christine, Walker, Lisa, Zhang, Wen Cai, Slack, Frank J

“…Many RNA species have been identified as important players in the development of chronic diseases, including cancer. Over the past decade, numerous studies…”
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