Search Results - "The Journal of cell biology"

LNCcation: lncRNA localization and function by Bridges, Mary Catherine, Daulagala, Amanda C, Kourtidis, Antonis

“…Subcellular localization of RNAs has gained attention in recent years as a prevalent phenomenon that influences numerous cellular processes. This is also…”
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Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling by Wang, Ying, Branicky, Robyn, Noë, Alycia, Hekimi, Siegfried

“…Superoxide dismutases (SODs) are universal enzymes of organisms that live in the presence of oxygen. They catalyze the conversion of superoxide into oxygen and…”
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Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation by Nguyen, Thanh Ngoc, Padman, Benjamin Scott, Usher, Joanne, Oorschot, Viola, Ramm, Georg, Lazarou, Michael

“…Members of the Atg8 family of proteins are conjugated to autophagosomal membranes, where they have been proposed to drive autophagosome formation and selective…”
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Microglia in Alzheimer's disease by Hansen, David V, Hanson, Jesse E, Sheng, Morgan

“…Proliferation and activation of microglia in the brain, concentrated around amyloid plaques, is a prominent feature of Alzheimer's disease (AD). Human genetics…”
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Recent insights into the cellular biology of atherosclerosis by Tabas, Ira, García-Cardeña, Guillermo, Owens, Gary K

“…Atherosclerosis occurs in the subendothelial space (intima) of medium-sized arteries at regions of disturbed blood flow and is triggered by an interplay…”
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Glutathione metabolism in cancer progression and treatment resistance by Bansal, Ankita, Simon, M Celeste

“…Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH…”
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Mitochondrial regulation of ferroptosis by Gan, Boyi

“…Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have…”
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Senescence and aging: Causes, consequences, and therapeutic avenues by McHugh, Domhnall, Gil, Jesús

“…Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the…”
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G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits by Kedersha, Nancy, Panas, Marc D, Achorn, Christopher A, Lyons, Shawn, Tisdale, Sarah, Hickman, Tyler, Thomas, Marshall, Lieberman, Judy, McInerney, Gerald M, Ivanov, Pavel, Anderson, Paul

“…Mammalian stress granules (SGs) contain stalled translation preinitiation complexes that are assembled into discrete granules by specific RNA-binding proteins…”
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SuperPlots: Communicating reproducibility and variability in cell biology by Lord, Samuel J, Velle, Katrina B, Mullins, R Dyche, Fritz-Laylin, Lillian K

“…P values and error bars help readers infer whether a reported difference would likely recur, with the sample size n used for statistical tests representing…”
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The position of lysosomes within the cell determines their luminal pH by Johnson, Danielle E, Ostrowski, Philip, Jaumouillé, Valentin, Grinstein, Sergio

“…We examined the luminal pH of individual lysosomes using quantitative ratiometric fluorescence microscopy and report an unappreciated heterogeneity: peripheral…”
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Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis by Eskandari, Ebrahim, Eaves, Connie J

“…Caspase-3 is a widely expressed member of a conserved family of proteins, generally recognized for their activated proteolytic roles in the execution of…”
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Pathways of cellular proteostasis in aging and disease by Klaips, Courtney L, Jayaraj, Gopal Gunanathan, Hartl, F Ulrich

“…Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein synthesis, folding, conformational maintenance, and degradation. A…”
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Lysosome biogenesis: Regulation and functions by Yang, Chonglin, Wang, Xiaochen

“…Lysosomes are degradation centers and signaling hubs in cells and play important roles in cellular homeostasis, development, and aging. Changes in lysosome…”
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ATG2 transports lipids to promote autophagosome biogenesis by Valverde, Diana P, Yu, Shenliang, Boggavarapu, Venkata, Kumar, Nikit, Lees, Joshua A, Walz, Thomas, Reinisch, Karin M, Melia, Thomas J

“…During macroautophagic stress, autophagosomes can be produced continuously and in high numbers. Many different organelles have been reported as potential donor…”
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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals by Quirós, Pedro M, Prado, Miguel A, Zamboni, Nicola, D'Amico, Davide, Williams, Robert W, Finley, Daniel, Gygi, Steven P, Auwerx, Johan

“…Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a…”
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Integrin-mediated mechanotransduction by Sun, Zhiqi, Guo, Shengzhen S, Fässler, Reinhard

“…Cells can detect and react to the biophysical properties of the extracellular environment through integrin-based adhesion sites and adapt to the extracellular…”
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Mechanistic insights into mammalian stress granule dynamics by Panas, Marc D, Ivanov, Pavel, Anderson, Paul

“…The accumulation of stalled translation preinitiation complexes (PICs) mediates the condensation of stress granules (SGs). Interactions between prion-related…”
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ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes by Larios, Jorge, Mercier, Vincent, Roux, Aurélien, Gruenberg, Jean

“…The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling receptors and other proteins to lysosomes for degradation, but they…”
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Lipid droplets in the nervous system by Ralhan, Isha, Chang, Chi-Lun, Lippincott-Schwartz, Jennifer, Ioannou, Maria S

“…Lipid droplets are dynamic intracellular lipid storage organelles that respond to the physiological state of cells. In addition to controlling cell metabolism,…”
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