Search Results - "The Journal of biological chemistry"

Mechanisms of evolved herbicide resistance by Gaines, Todd A., Duke, Stephen O., Morran, Sarah, Rigon, Carlos A.G., Tranel, Patrick J., Küpper, Anita, Dayan, Franck E.

“…The widely successful use of synthetic herbicides over the past 70 years has imposed strong and widespread selection pressure, leading to the evolution of…”
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Cell adhesion in cancer: Beyond the migration of single cells by Janiszewska, Michalina, Primi, Marina Candido, Izard, Tina

“…Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-extracellular matrix interactions. For instance, normal epithelial cells…”
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The molecular language of membraneless organelles by Gomes, Edward, Shorter, James

“…Eukaryotic cells organize their intracellular components into organelles that can be membrane-bound or membraneless. A large number of membraneless organelles,…”
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Ethylene signaling in plants by Binder, Brad M.

“…Ethylene is a gaseous phytohormone and the first of this hormone class to be discovered. It is the simplest olefin gas and is biosynthesized by plants to…”
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Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template by Gordon, Calvin J., Tchesnokov, Egor P., Schinazi, Raymond F., Götte, Matthias

“…The RNA-dependent RNA polymerase of the severe acute respiratory syndrome coronavirus 2 is an important target in current drug development efforts for the…”
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The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus by Gordon, Calvin J., Tchesnokov, Egor P., Feng, Joy Y., Porter, Danielle P., Götte, Matthias

“…Antiviral drugs for managing infections with human coronaviruses are not yet approved, posing a serious challenge to current global efforts aimed at containing…”
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The essential elements of Alzheimer’s disease by Lei, Peng, Ayton, Scott, Bush, Ashley I.

“…Treatments for Alzheimer’s disease (AD) directed against the prominent amyloid plaque neuropathology are yet to be proved effective despite many phase 3…”
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The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends by Pobre, Kristine Faye R., Poet, Greg J., Hendershot, Linda M.

“…The endoplasmic reticulum (ER) represents the entry point into the secretory pathway where nascent proteins encounter a specialized environment for their…”
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Thirty sweet years of GLUT4 by Klip, Amira, McGraw, Timothy E., James, David E.

“…A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and adipose tissues. The discovery of the insulin-responsive glucose…”
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Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications by Li, Zhong, Jiang, Yuanyuan, Guengerich, F. Peter, Ma, Li, Li, Shengying, Zhang, Wei

“…Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and play crucial roles in natural product biosynthesis, degradation of…”
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Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions by Wong, Hoi-Shan, Dighe, Pratiksha A., Mezera, Vojtech, Monternier, Pierre-Axel, Brand, Martin D.

“…Mitochondrial production of superoxide and hydrogen peroxide is potentially important in cell signaling and disease. Eleven distinct mitochondrial sites that…”
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Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling by Genest, Olivier, Wickner, Sue, Doyle, Shannon M.

“…Heat shock proteins 90 (Hsp90) and 70 (Hsp70) are two families of highly conserved ATP-dependent molecular chaperones that fold and remodel proteins. Both are…”
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Functions of Polyamines in Mammals by Pegg, Anthony E.

“…The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative…”
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The role of liquid–liquid phase separation in aggregation of the TDP-43 low-complexity domain by Babinchak, W. Michael, Haider, Raza, Dumm, Benjamin K., Sarkar, Prottusha, Surewicz, Krystyna, Choi, Jin-Kyu, Surewicz, Witold K.

“…Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-43) is associated with several neurodegenerative disorders, including…”
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Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs by Lin, Yuan, Currie, Simon L., Rosen, Michael K.

“…Liquid–liquid phase separation (LLPS) is thought to contribute to the establishment of many biomolecular condensates, eukaryotic cell structures that…”
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Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants by Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.

“…The COVID-19 pandemic continues to be a public health threat with emerging variants of SARS-CoV-2. Nirmatrelvir (PF-07321332) is a reversible, covalent…”
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Antisense technology: A review by Crooke, Stanley T., Liang, Xue-Hai, Baker, Brenda F., Crooke, Rosanne M.

“…Antisense technology is beginning to deliver on the broad promise of the technology. Ten RNA-targeted drugs including eight single-strand antisense drugs…”
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Mitochondrial metabolism regulates macrophage biology by Wang, Yafang, Li, Na, Zhang, Xin, Horng, Tiffany

“…Mitochondria are critical for regulation of the activation, differentiation, and survival of macrophages and other immune cells. In response to various…”
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Iron–sulfur cluster biogenesis and trafficking in mitochondria by Braymer, Joseph J., Lill, Roland

“…The biogenesis of iron–sulfur (Fe/S) proteins in eukaryotes is a multistage, multicompartment process that is essential for a broad range of cellular…”
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Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury by Su, Lianjiu, Jiang, Xiaofang, Yang, Cheng, Zhang, Jiahao, Chen, Bo, Li, Yiming, Yao, Shijie, Xie, Qin, Gomez, Hernando, Murugan, Raghavan, Peng, Zhiyong

“…Renal ischemia/reperfusion injury (IRI) is a significant challenge in perioperative medicine and is related to oxidative programmed cell death. However, the…”
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