Search Results - "The International Journal of Neuropsychopharmacology"

Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior by Luczynski, Pauline, McVey Neufeld, Karen-Anne, Oriach, Clara Seira, Clarke, Gerard, Dinan, Timothy G., Cryan, John F.

“…There is a growing recognition of the importance of the commensal intestinal microbiota in the development and later function of the central nervous system…”
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Making Sense of Rodent Models of Anhedonia by Scheggi, Simona, De Montis, Maria Graziella, Gambarana, Carla

“…A markedly reduced interest or pleasure in activities previously considered pleasurable is a main symptom in mood disorder and psychosis and is often present…”
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Glutamatergic Neurotransmission: Pathway to Developing Novel Rapid-Acting Antidepressant Treatments by Kadriu, Bashkim, Musazzi, Laura, Henter, Ioline D, Graves, Morgan, Popoli, Maurizio, Zarate, Jr, Carlos A

“…The underlying neurobiological basis of major depressive disorder remains elusive due to the severity, complexity, and heterogeneity of the disorder. While the…”
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An Insight into Z-Drug Abuse and Dependence: An Examination of Reports to the European Medicines Agency Database of Suspected Adverse Drug Reactions by Schifano, Fabrizio, Chiappini, Stefania, Corkery, John M, Guirguis, Amira

“…Abstract Background Although originally marketed as safe alternatives to the habit-forming benzodiazepines, growing numbers of zaleplon, zolpidem, and…”
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Effects of Low-Dose and Very Low-Dose Ketamine among Patients with Major Depression: a Systematic Review and Meta-Analysis by Xu, Ying, Hackett, Maree, Carter, Gregory, Loo, Colleen, Gálvez, Verònica, Glozier, Nick, Glue, Paul, Lapidus, Kyle, McGirr, Alexander, Somogyi, Andrew A., Mitchell, Philip B., Rodgers, Anthony

“…Background: Several recent trials indicate low-dose ketamine produces rapid antidepressant effects. However, uncertainty remains in several areas: dose…”
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Improving Functioning, Quality of Life, and Well-being in Patients With Bipolar Disorder by Bonnín, Caterina Del Mar, Reinares, María, Martínez-Arán, Anabel, Jiménez, Esther, Sánchez-Moreno, Jose, Solé, Brisa, Montejo, Laura, Vieta, Eduard

“…People with bipolar disorder frequently experience persistent residual symptoms, problems in psychosocial functioning, cognitive impairment, and poor quality…”
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Prevention of Relapse and Recurrence in Adults with Major Depressive Disorder: Systematic Review and Meta-Analyses of Controlled Trials by Sim, Kang, Lau, Wai Keat, Sim, Jordan, Sum, Min Yi, Baldessarini, Ross J.

“…Background: Findings of substantial remaining morbidity in treated major depressive disorder (MDD) led us to review controlled trials of treatments aimed at…”
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Gut Microbiota and Brain Function: An Evolving Field in Neuroscience by Foster, Jane A, Lyte, Mark, Meyer, Emeran, Cryan, John F

“…There is a growing appreciation of the importance of gut microbiota to health and disease. This has been driven by advances in sequencing technology and recent…”
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Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders by Fregni, Felipe, El-Hagrassy, Mirret M, Pacheco-Barrios, Kevin, Carvalho, Sandra, Leite, Jorge, Simis, Marcel, Brunelin, Jerome, Nakamura-Palacios, Ester Miyuki, Marangolo, Paola, Venkatasubramanian, Ganesan, San-Juan, Daniel, Caumo, Wolnei, Bikson, Marom, Brunoni, André R

“…Abstract Background Transcranial direct current stimulation has shown promising clinical results, leading to increased demand for an evidence-based review on…”
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Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders by Gawryluk, Jeremy W., Wang, Jun-Feng, Andreazza, Ana C., Shao, Li, Young, L. Trevor

“…Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major depressive disorder (MDD), and…”
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Interferon-Alpha Reduces Human Hippocampal Neurogenesis and Increases Apoptosis via Activation of Distinct STAT1-Dependent Mechanisms by Borsini, Alessandra, Cattaneo, Annamaria, Malpighi, Chiara, Thuret, Sandrine, Harrison, Neil A, Zunszain, Patricia A, Pariante, Carmine M

“…In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular…”
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Oxidative stress in psychiatric disorders: evidence base and therapeutic implications by Ng, Felicity, Berk, Michael, Dean, Olivia, Bush, Ashley I.

“…Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric…”
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The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm by Fountoulakis, Konstantinos N., Yatham, Lakshmi, Grunze, Heinz, Vieta, Eduard, Young, Allan, Blier, Pierre, Kasper, Siegfried, Moeller, Hans Jurgen

“…Abstract Background: The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment…”
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Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients by Cattaneo, Annamaria, Ferrari, Clarissa, Uher, Rudolf, Bocchio-Chiavetto, Luisella, Riva, Marco Andrea, Pariante, Carmine M.

“…Background: Increased levels of inflammation have been associated with a poorer response to antidepressants in several clinical samples, but these findings…”
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Small Extracellular Vesicles in Rat Serum Contain Astrocyte-Derived Protein Biomarkers of Repetitive Stress by Gómez-Molina, Cristóbal, Sandoval, Mauricio, Henzi, Roberto, Ramírez, Juan Pablo, Varas-Godoy, Manuel, Luarte, Alejandro, Lafourcade, Carlos Andres, Lopez-Verrilli, Alejandra, Smalla, Karl-Heinz, Kaehne, Thilo, Wyneken, Ursula

“…Abstract Background Stress precipitates mood disorders, characterized by a range of symptoms present in different combinations, suggesting the existence of…”
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Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1) by Fedgchin, Maggie, Trivedi, Madhukar, Daly, Ella J, Melkote, Rama, Lane, Rosanne, Lim, Pilar, Vitagliano, Dawn, Blier, Pierre, Fava, Maurizio, Liebowitz, Michael, Ravindran, Arun, Gaillard, Raphael, Ameele, Hans Van Den, Preskorn, Sheldon, Manji, Husseini, Hough, David, Drevets, Wayne C, Singh, Jaskaran B

“…About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have…”
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Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene by Wei, Yabin, Melas, Philippe A, Wegener, Gregers, Mathé, Aleksander A, Lavebratt, Catharina

“…Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant…”
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Major Depression and the Degree of Suicidality: Results of the European Group for the Study of Resistant Depression (GSRD) by Dold, Markus, Bartova, Lucie, Fugger, Gernot, Kautzky, Alexander, Souery, Daniel, Mendlewicz, Julien, Papadimitriou, George N, Dikeos, Dimitris, Ferentinos, Panagiotis, Porcelli, Stefano, Serretti, Alessandro, Zohar, Joseph, Montgomery, Stuart, Kasper, Siegfried

“…This European multicenter study aimed to elucidate suicidality in major depressive disorder. Previous surveys suggest a prevalence of suicidality in major…”
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A double-blind, randomized, placebo-controlled, active reference study of Lu AA21004 in patients with major depressive disorder by Alvarez, Enric, Perez, Victor, Dragheim, Marianne, Loft, Henrik, Artigas, Francesc

“…The efficacy, safety, and tolerability of Lu AA21004 vs. placebo using venlafaxine XR as active reference in patients with DSM-IV-TR major depressive disorder…”
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Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response by Domschke, Katharina, Tidow, Nicola, Schwarte, Kathrin, Deckert, Jürgen, Lesch, Klaus-Peter, Arolt, Volker, Zwanzger, Peter, Baune, Bernhard T.

“…Variation in the serotonin transporter gene (5-HTT; SERT; SLC6A4) has been suggested to pharmacogenetically drive interindividual differences in antidepressant…”
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