Search Results - "The FEBS journal"

A guide to the composition and functions of the extracellular matrix by Karamanos, Nikos K., Theocharis, Achilleas D., Piperigkou, Zoi, Manou, Dimitra, Passi, Alberto, Skandalis, Spyros S., Vynios, Demitrios H., Orian‐Rousseau, Véronique, Ricard‐Blum, Sylvie, Schmelzer, Christian E.H., Duca, Laurent, Durbeej, Madeleine, Afratis, Nikolaos A., Troeberg, Linda, Franchi, Marco, Masola, Valentina, Onisto, Maurizio

“…Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated…”
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Signaling pathways and defense mechanisms of ferroptosis by Liu, Jiao, Kang, Rui, Tang, Daolin

“…As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma membrane damage, ferroptosis occurs and develops because of…”
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A guide to chemokines and their receptors by Hughes, Catherine E., Nibbs, Robert J. B.

“…The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G protein‐coupled heptahelical…”
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Targeting cellular senescence with senotherapeutics: senolytics and senomorphics by Zhang, Lei, Pitcher, Louise E., Prahalad, Vaishali, Niedernhofer, Laura J., Robbins, Paul D.

“…The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the…”
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Glycolysis – a key player in the inflammatory response by Soto‐Heredero, Gonzalo, Gómez de las Heras, Manuel M., Gabandé‐Rodríguez, Enrique, Oller, Jorge, Mittelbrunn, María

“…The inflammatory response involves the activation of several cell types to fight insults caused by a plethora of agents, and to maintain the tissue…”
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Bax, Bak and beyond — mitochondrial performance in apoptosis by Peña‐Blanco, Aida, García‐Sáez, Ana J.

“…Bax and Bak are members of the Bcl‐2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and…”
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New insights into the activities and toxicities of the old anticancer drug doxorubicin by van der Zanden, Sabina Y., Qiao, Xiaohang, Neefjes, Jacques

“…The anthracycline drug doxorubicin is an effective anticancer drugs with both DNA‐ and chromatin‐damaging activity. While the chromatin‐damaging activity…”
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ADP‐ribosyltransferases, an update on function and nomenclature by Lüscher, Bernhard, Ahel, Ivan, Altmeyer, Matthias, Ashworth, Alan, Bai, Peter, Chang, Paul, Cohen, Michael, Corda, Daniela, Dantzer, Françoise, Daugherty, Matthew D., Dawson, Ted M., Dawson, Valina L., Deindl, Sebastian, Fehr, Anthony R., Feijs, Karla L. H., Filippov, Dmitri V., Gagné, Jean‐Philippe, Grimaldi, Giovanna, Guettler, Sebastian, Hoch, Nicolas C., Hottiger, Michael O., Korn, Patricia, Kraus, W. Lee, Ladurner, Andreas, Lehtiö, Lari, Leung, Anthony K. L., Lord, Christopher J., Mangerich, Aswin, Matic, Ivan, Matthews, Jason, Moldovan, George‐Lucian, Moss, Joel, Natoli, Gioacchino, Nielsen, Michael L., Niepel, Mario, Nolte, Friedrich, Pascal, John, Paschal, Bryce M., Pawłowski, Krzysztof, Poirier, Guy G., Smith, Susan, Timinszky, Gyula, Wang, Zhao‐Qi, Yélamos, José, Yu, Xiaochun, Zaja, Roko, Ziegler, Mathias

“…ADP‐ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for…”
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Rab family of small GTPases: an updated view on their regulation and functions by Homma, Yuta, Hiragi, Shu, Fukuda, Mitsunori

“…The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of…”
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Multifunctional intracellular matrix metalloproteinases: implications in disease by Bassiouni, Wesam, Ali, Mohammad A. M., Schulz, Richard

“…Matrix metalloproteinases (MMPs) are zinc‐dependent endopeptidases that were first discovered as proteases, which target and cleave extracellular proteins…”
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A guide to plasma membrane solute carrier proteins by Pizzagalli, Mattia D., Bensimon, Ariel, Superti‐Furga, Giulio

“…This review aims to serve as an introduction to the solute carrier proteins (SLC) superfamily of transporter proteins and their roles in human cells. The SLC…”
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Cell death induced by endoplasmic reticulum stress by Iurlaro, Raffaella, Muñoz‐Pinedo, Cristina

“…The endoplasmic reticulum is an organelle with multiple functions. The synthesis of transmembrane proteins and proteins that are to be secreted occurs in this…”
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The extracellular matrix as a multitasking player in disease by Theocharis, Achilleas D., Manou, Dimitra, Karamanos, Nikos K.

“…Extracellular matrices (ECMs) are highly specialized and dynamic three‐dimensional (3D) scaffolds into which cells reside in tissues. ECM is composed of a…”
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Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer by Tavianatou, Anastasia G., Caon, Ilaria, Franchi, Marco, Piperigkou, Zoi, Galesso, Devis, Karamanos, Nikos K.

“…Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that plays a pivotal role in a variety of biological processes…”
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Glucose transporters in cancer – from tumor cells to the tumor microenvironment by Ancey, Pierre‐Benoit, Contat, Caroline, Meylan, Etienne

“…Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose usage. The upregulation of GLUTs has been reported in…”
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A guide to: generation and design of nanobodies by Muyldermans, Serge

“…Immune or naïve nanobody (Nb) repertoires are cloned from B lymphocytes of camelids. Alternatively, synthetic Nb libraries are generated in vitro by…”
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Endoplasmic reticulum stress signalling – from basic mechanisms to clinical applications by Almanza, Aitor, Carlesso, Antonio, Chintha, Chetan, Creedican, Stuart, Doultsinos, Dimitrios, Leuzzi, Brian, Luís, Andreia, McCarthy, Nicole, Montibeller, Luigi, More, Sanket, Papaioannou, Alexandra, Püschel, Franziska, Sassano, Maria Livia, Skoko, Josip, Agostinis, Patrizia, Belleroche, Jackie, Eriksson, Leif A., Fulda, Simone, Gorman, Adrienne M., Healy, Sandra, Kozlov, Andrey, Muñoz‐Pinedo, Cristina, Rehm, Markus, Chevet, Eric, Samali, Afshin

“…The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the…”
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Cellular senescence: all roads lead to mitochondria by Martini, Hélène, Passos, João F.

“…Senescence is a multi‐functional cell fate, characterized by an irreversible cell‐cycle arrest and a pro‐inflammatory phenotype, commonly known as the…”
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Low plasma 25(OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study by Merzon, Eugene, Tworowski, Dmitry, Gorohovski, Alessandro, Vinker, Shlomo, Golan Cohen, Avivit, Green, Ilan, Frenkel‐Morgenstern, Milana

“…Vitamin D deficiency is a worldwide pandemic. The aim of this study was to evaluate associations of plasma 25(OH)D levels with the likelihood of coronavirus…”
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p62/SQSTM1 functions as a signaling hub and an autophagy adaptor by Katsuragi, Yoshinori, Ichimura, Yoshinobu, Komatsu, Masaaki

“…p62/SQSTM1 is a stress‐inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple domains that mediate…”
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