Search Results - "The FASEB Journal"

Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis by Adebayo, Mary, Singh, Seema, Singh, Ajay Pratap, Dasgupta, Santanu

“…Mitochondria are highly dynamic, maternally inherited cytoplasmic organelles, which fulfill cellular energy demand through the oxidative phosphorylation…”
Get full text

Blood contains circulating cell‐free respiratory competent mitochondria by Al Amir Dache, Zahra, Otandault, Amaëlle, Tanos, Rita, Pastor, Brice, Meddeb, Romain, Sanchez, Cynthia, Arena, Giuseppe, Lasorsa, Laurence, Bennett, Andrew, Grange, Thierry, El Messaoudi, Safia, Mazard, Thibault, Prevostel, Corinne, Thierry, Alain R.

“…Mitochondria are considered as the power‐generating units of the cell due to their key role in energy metabolism and cell signaling. However, mitochondrial…”
Get full text

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms by Serhan, Charles N.

“…Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain…”
Get full text

LC3/GABARAP family proteins: autophagy‐(un)related functions by Schaaf, Marco B. E., Keulers, Tom G., Vooijs, Marc A., Rouschop, Kasper M. A.

“…ABSTRACT From yeast to mammals, autophagy is an important mechanism for sustaining cellular homeostasis through facilitating the degradation and recycling of…”
Get full text

Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells by Reigstad, Christopher S., Salmonson, Charles E., III, John F. Rainey, Szurszewski, Joseph H., Linden, David R., Sonnenburg, Justin L., Farrugia, Gianrico, Kashyap, Purna C.

“…Gut microbiota alterations have been described in several diseases with altered gastrointestinal (GI) motility, and awareness is increasing regarding the role…”
Get full text

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC by Siu, Kam‐Leung, Yuen, Kit‐San, Castano‐Rodriguez, Carlos, Ye, Zi‐Wei, Yeung, Man‐Lung, Fung, Sin‐Yee, Yuan, Shuofeng, Chan, Chi‐Ping, Yuen, Kwok‐Yung, Enjuanes, Luis, Jin, Dong‐Yan

“…ABSTRACT Severe acute respiratory syndrome Coronavirus (SARS‐CoV) is capable of inducing a storm of proinflammatory cytokines. In this study, we show that the…”
Get full text

Expression, regulation, and function of exosome‐derived miRNAs in cancer progression and therapy by Li, Bowen, Cao, Yu, Sun, Mingjun, Feng, Hui

“…Exosomes are a novel class of intercellular signal modulators that contain a wide range of molecules and deliver information between cells and tissues…”
Get full text

Hydrogen sulfide signaling in mitochondria and disease by Murphy, Brennah, Bhattacharya, Resham, Mukherjee, Priyabrata

“…Hydrogen sulfide can signal through 3 distinct mechanisms: 1) reduction and/or direct binding of metalloprotein heme centers, 2) serving as a potent…”
Get full text

Rationale for the use of N‐acetylcysteine in both prevention and adjuvant therapy of COVID‐19 by De Flora, Silvio, Balansky, Roumen, La Maestra, Sebastiano

“…COVID‐19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a…”
Get full text

Activation of ROS/MAPKs/NF‐κB/NLRP3 and inhibition of efferocytosis in osteoclast‐mediated diabetic osteoporosis by An, Yanan, Zhang, Haifeng, Wang, Chao, Jiao, Fangtai, Xu, Hongyue, Wang, Xuefei, Luan, Wenjing, Ma, Fangxue, Ni, Lihui, Tang, Xudong, Liu, Mingyuan, Guo, Weiying, Yu, Lu

“…Diabetes mellitus (DM) affects bone metabolism and leads to osteoporosis; however, its pathogenetic mechanisms remain unknown. We found that high glucose (HG)…”
Get full text

Origin and functional heterogeneity of fibroblasts by LeBleu, Valerie S., Neilson, Eric G.

“…The inherent plasticity and resiliency of fibroblasts make this cell type a conventional tool for basic research. But where do they come from, are all…”
Get full text

Amyloid precursor protein and endosomal‐lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease by Nixon, Ralph A.

“…ABSTRACT Abnormalities of the endosomal–lysosomal network (ELN) are a signature feature of Alzheimer's disease (AD). These include the earliest known…”
Get full text

Noncoding RNAs, cytokines, and inflammation‐related diseases by Marques‐Rocha, José Luiz, Samblas, Mirian, Milagro, Fermin I., Bressan, Josefina, Martínez, J. Alfredo, Marti, Amelia

“…ABSTRACT Chronic inflammation is involved in the onset and development of many diseases, including obesity, atherosclerosis, type 2 diabetes, osteoarthritis,…”
Get full text

Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease by Goetzl, Edward J., Kapogiannis, Dimitrios, Schwartz, Janice B., Lobach, Iryna V., Goetzl, Laura, Abner, Erin L., Jicha, Gregory A., Karydas, Anna M., Boxer, Adam, Miller, Bruce L.

“…ABSTRACT Synaptic dysfunction occurs early in senile dementias, presumably as a result of decreased levels of functional synaptic proteins as found in…”
Get full text

Clinical sensitivity and interpretation of PCR and serological COVID‐19 diagnostics for patients presenting to the hospital by Miller, Tyler E., Garcia Beltran, Wilfredo F., Bard, Adam Z., Gogakos, Tasos, Anahtar, Melis N., Astudillo, Michael Gerino, Yang, Diane, Thierauf, Julia, Fisch, Adam S., Mahowald, Grace K., Fitzpatrick, Megan J., Nardi, Valentina, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Marble, Hetal D., Ritterhouse, Lauren L., Turbett, Sara E., Batten, Julie, Georgantas, Nicholas Zeke, Alter, Galit, Schmidt, Aaron G., Harris, Jason B., Gelfand, Jeffrey A., Poznansky, Mark C., Bernstein, Bradley E., Louis, David N., Dighe, Anand, Charles, Richelle C., Ryan, Edward T., Branda, John A., Pierce, Virginia M., Murali, Mandakolathur R., Iafrate, A. John, Rosenberg, Eric S., Lennerz, Jochen K.

“…The diagnosis of COVID‐19 requires integration of clinical and laboratory data. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) diagnostic assays…”
Get full text

Considering sex as a biological variable in preclinical research by Miller, Leah R., Marks, Cheryl, Becker, Jill B., Hurn, Patricia D., Chen, Wei‐Jung, Woodruff, Teresa, McCarthy, Margaret M., Sohrabji, Farida, Schiebinger, Londa, Wetherington, Cora Lee, Makris, Susan, Arnold, Arthur P., Einstein, Gillian, Miller, Virginia M., Sandberg, Kathryn, Maier, Susan, Cornelison, Terri L., Clayton, Janine A.

“…In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT‐OD‐15–102) that highlighted the expectation of the NIH that the possible…”
Get full text

Cargo proteins of plasma astrocyte‐derived exosomes in Alzheimer's disease by Goetzl, Edward J., Mustapic, Maja, Kapogiannis, Dimitrios, Eitan, Erez, Lobach, Irina V., Goetzl, Laura, Schwartz, Janice B., Miller, Bruce L.

“…ABSTRACT Efficient intercellular transfer of RNAs, proteins, and lipids as protected exosomal cargo has been demonstrated in the CNS, but distinct physiologic…”
Get full text

Tissue‐specific regulation of cytochrome c by post‐translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis by Kalpage, Hasini A., Bazylianska, Viktoriia, Recanati, Maurice A., Fite, Alemu, Liu, Jenney, Wan, Junmei, Mantena, Nikhil, Malek, Moh H., Podgorski, Izabela, Heath, Elizabeth I., Vaishnav, Asmita, Edwards, Brian F., Grossman, Lawrence I., Sanderson, Thomas H., Lee, Icksoo, Huttemann, Maik

“…ABSTRACT Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In addition, it is a key regulator of apoptosis. Cytc has…”
Get full text

COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches by Sorokin, Alexander V., Karathanasis, Sotirios K., Yang, Zhi‐Hong, Freeman, Lita, Kotani, Kazuhiko, Remaley, Alan T.

“…The current coronavirus disease 2019 (COVID‐19) pandemic presents a global challenge for managing acutely ill patients and complications from viral infection…”
Get full text

Extracellular RNAs in periodontopathogenic outer membrane vesicles promote TNF‐α production in human macrophages and cross the blood‐brain barrier in mice by Han, Eun‐Chong, Choi, Song‐Yi, Lee, Youngkyun, Park, Jin‐Woo, Hong, Su‐Hyung, Lee, Heon‐Jin

“…Among the main bacteria implicated in the pathology of periodontal disease, Aggregatibacter actinomycetemcomitans (Aa) is well known for causing loss of…”
Get full text