Search Results - "The American journal of surgical pathology"

Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer by Steiner, David F, MacDonald, Robert, Liu, Yun, Truszkowski, Peter, Hipp, Jason D, Gammage, Christopher, Thng, Florence, Peng, Lily, Stumpe, Martin C

“…Advances in the quality of whole-slide images have set the stage for the clinical use of digital images in anatomic pathology. Along with advances in computer…”
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Pan-Trk Immunohistochemistry Is an Efficient and Reliable Screen for the Detection of NTRK Fusions by Hechtman, Jaclyn F, Benayed, Ryma, Hyman, David M, Drilon, Alexander, Zehir, Ahmet, Frosina, Denise, Arcila, Maria E, Dogan, Snjezana, Klimstra, David S, Ladanyi, Marc, Jungbluth, Achim A

“…Activating neurotrophic tyrosine receptor kinase (NTRK) fusions, typically detected using nucleic-acid based assays, are highly targetable and define certain…”
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NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma by Chiang, Sarah, Cotzia, Paolo, Hyman, David M, Drilon, Alexander, Tap, William D, Zhang, Lei, Hechtman, Jaclyn F, Frosina, Denise, Jungbluth, Achim A, Murali, Rajmohan, Park, Kay J, Soslow, Robert A, Oliva, Esther, Iafrate, A John, Benayed, Ryma, Ladanyi, Marc, Antonescu, Cristina R

“…Tropomyosin receptor kinase (Trk) inhibitors have shown high response rates in patients with tumors harboring NTRK fusions. We identified 4 NTRK…”
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A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas by Basturk, Olca, Hong, Seung-Mo, Wood, Laura D, Adsay, N Volkan, Albores-Saavedra, Jorge, Biankin, Andrew V, Brosens, Lodewijk A.A, Fukushima, Noriyoshi, Goggins, Michael, Hruban, Ralph H, Kato, Yo, Klimstra, David S, Klöppel, Günter, Krasinskas, Alyssa, Longnecker, Daniel S, Matthaei, Hanno, Offerhaus, G. Johan A, Shimizu, Michio, Takaori, Kyoichi, Terris, Benoit, Yachida, Shinichi, Esposito, Irene, Furukawa, Toru

“…International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive…”
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Proposed Morphologic Classification of Prostate Cancer With Neuroendocrine Differentiation by Epstein, Jonathan I, Amin, Mahul B, Beltran, Himisha, Lotan, Tamara L, Mosquera, Juan-Miguel, Reuter, Victor E, Robinson, Brian D, Troncoso, Patricia, Rubin, Mark A

“…On July 31, 2013, the Prostate Cancer Foundation assembled a working committee on the molecular biology and pathologic classification of neuroendocrine (NE)…”
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PRAME Expression in Melanocytic Tumors by Lezcano, Cecilia, Jungbluth, Achim A, Nehal, Kishwer S, Hollmann, Travis J, Busam, Klaus J

“…PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen that was isolated by autologous T cells in a melanoma patient. While…”
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BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities by Kao, Yu-Chien, Sung, Yun-Shao, Zhang, Lei, Jungbluth, Achim A, Huang, Shih-Chiang, Argani, Pedram, Agaram, Narasimhan P, Zin, Angelica, Alaggio, Rita, Antonescu, Cristina R

“…With the advent of next-generation sequencing, an increasing number of novel gene fusions and other abnormalities have emerged recently in the spectrum of…”
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The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia by Srigley, John R., Delahunt, Brett, Eble, John N., Egevad, Lars, Epstein, Jonathan I., Grignon, David, Hes, Ondrej, Moch, Holger, Montironi, Rodolfo, Tickoo, Satish K., Zhou, Ming, Argani, Pedram

“…The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making…”
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Comparison of Immunohistochemistry for PRAME With Cytogenetic Test Results in the Evaluation of Challenging Melanocytic Tumors by Lezcano, Cecilia, Jungbluth, Achim A., Busam, Klaus J.

“…PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen. Although diffuse immunoreactivity for PRAME is found in most primary…”
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A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma by Baranov, Esther, McBride, Matthew J., Bellizzi, Andrew M., Ligon, Azra H., Fletcher, Christopher D.M., Kadoch, Cigall, Hornick, Jason L.

“…Synovial sarcoma (SS), an aggressive soft tissue sarcoma with a predilection for the extremities of young adults, harbors the pathognomonic t(X;18)(p11;q11)…”
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Somatic Mutations of TSC2 or MTOR Characterize a Morphologically Distinct Subset of Sporadic Renal Cell Carcinoma With Eosinophilic and Vacuolated Cytoplasm by Chen, Ying-Bei, Mirsadraei, Leili, Jayakumaran, Gowtham, Al-Ahmadie, Hikmat A, Fine, Samson W, Gopalan, Anuradha, Sirintrapun, S Joseph, Tickoo, Satish K, Reuter, Victor E

“…The differential diagnosis of renal cell neoplasms with solid or nested architecture and eosinophilic cytoplasm has become increasingly complex. Despite recent…”
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Immunohistochemistry for PRAME in the Distinction of Nodal Nevi From Metastatic Melanoma by Lezcano, Cecilia, Pulitzer, Melissa, Moy, Andrea P., Hollmann, Travis J., Jungbluth, Achim A., Busam, Klaus J.

“…The distinction of metastatic melanoma from melanocytic nevi in lymph nodes can on occasion be difficult. As diffuse immunohistochemical (IHC) PRAME…”
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The High-grade (WHO G3) Pancreatic Neuroendocrine Tumor Category Is Morphologically and Biologically Heterogenous and Includes Both Well Differentiated and Poorly Differentiated Neoplasms by Basturk, Olca, Yang, Zhaohai, Tang, Laura H, Hruban, Ralph H, Adsay, Volkan, McCall, Chad M, Krasinskas, Alyssa M, Jang, Kee-Taek, Frankel, Wendy L, Balci, Serdar, Sigel, Carlie, Klimstra, David S

“…The 2010 World Health Organization (WHO) classification recommends that pancreatic neuroendocrine tumors (PanNETs) be graded on the basis of the mitotic rate…”
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A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WD-NET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas by Tang, Laura H, Basturk, Olca, Sue, Jillian J, Klimstra, David S

“…High-grade neuroendocrine neoplasms (World Health Organization [WHO] G3) of the pancreas include both well-differentiated neuroendocrine tumor (WD-NET) and…”
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Spindle Cell Tumors With RET Gene Fusions Exhibit a Morphologic Spectrum Akin to Tumors With NTRK Gene Fusions by Antonescu, Cristina R, Dickson, Brendan C, Swanson, David, Zhang, Lei, Sung, Yun-Shao, Kao, Yu-Chien, Chang, Wei-Chin, Ran, Leili, Pappo, Alberto, Bahrami, Armita, Chi, Ping, Fletcher, Christopher D

“…A major breakthrough in the classification of soft tissue tumors has been the recent identification of NTRK-fusion related neoplasms which are amenable to…”
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Lynch Syndrome Screening Should Be Considered for All Patients With Newly Diagnosed Endometrial Cancer by Mills, Anne M, Liou, Sofia, Ford, James M, Berek, Jonathan S, Pai, Reetesh K, Longacre, Teri A

“…Lynch syndrome (LS) is an autosomal dominant inherited disorder caused by germline mutations in DNA mismatch repair (MMR) genes. Mutation carriers are at…”
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EWSR1 Fusions With CREB Family Transcription Factors Define a Novel Myxoid Mesenchymal Tumor With Predilection for Intracranial Location by Kao, Yu-Chien, Sung, Yun-Shao, Zhang, Lei, Chen, Chun-Liang, Vaiyapuri, Sumathi, Rosenblum, Marc K, Antonescu, Cristina R

“…Recurrent gene fusions involving EWSR1 with members of the cAMP response element binding protein (CREB) family (ATF1 and CREB1) have been reported in a diverse…”
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Prognostic Significance of Adenocarcinoma In Situ, Minimally Invasive Adenocarcinoma, and Nonmucinous Lepidic Predominant Invasive Adenocarcinoma of the Lung in Patients With Stage I Disease by Kadota, Kyuichi, Villena-Vargas, Jonathan, Yoshizawa, Akihiko, Motoi, Noriko, Sima, Camelia S, Riely, Gregory J, Rusch, Valerie W, Adusumilli, Prasad S, Travis, William D

“…According to the IASLC/ATS/ERS classification, the lepidic predominant pattern consists of 3 subtypesadenocarcinoma in situ (AIS), minimally invasive…”
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Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors by Agaram, Narasimhan P, Zhang, Lei, Sung, Yun-Shao, Chen, Chun-Liang, Chung, Catherine T, Antonescu, Cristina R, Fletcher, Christopher DM

“…The family of pediatric fibroblastic and myofibroblastic proliferations encompasses a wide spectrum of pathologic entities with overlapping morphologies and…”
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Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas by Specht, Katja, Zhang, Lei, Sung, Yun-Shao, Nucci, Marisa, Dry, Sarah, Vaiyapuri, Sumathi, Richter, Gunther H.S, Fletcher, Christopher D.M, Antonescu, Cristina R

“…Small blue round cell tumors (SBRCTs) are a heterogenous group of tumors that are difficult to diagnose because of overlapping morphologic,…”
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