Search Results - "The American journal of pathology"

Immunopathology of Hyperinflammation in COVID-19 by Gustine, Joshua N., Jones, Dennis

“…The rapid spread of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), has resulted in an…”
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Pathology Image Analysis Using Segmentation Deep Learning Algorithms by Wang, Shidan, Yang, Donghan M., Rong, Ruichen, Zhan, Xiaowei, Xiao, Guanghua

“…With the rapid development of image scanning techniques and visualization software, whole slide imaging (WSI) is becoming a routine diagnostic method…”
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Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas by Christensen, Paul A., Olsen, Randall J., Long, S. Wesley, Snehal, Richard, Davis, James J., Ojeda Saavedra, Matthew, Reppond, Kristina, Shyer, Madison N., Cambric, Jessica, Gadd, Ryan, Thakur, Rashi M., Batajoo, Akanksha, Mangham, Regan, Pena, Sindy, Trinh, Trina, Kinskey, Jacob C., Williams, Guy, Olson, Robert, Gollihar, Jimmy, Musser, James M.

“…Genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to dramatically alter the landscape of the coronavirus disease 2019…”
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Treatment of Coronavirus Disease 2019 (COVID-19) Patients with Convalescent Plasma by Salazar, Eric, Perez, Katherine K., Ashraf, Madiha, Chen, Jian, Castillo, Brian, Christensen, Paul A., Eubank, Taryn, Bernard, David W., Eagar, Todd N., Long, S. Wesley, Subedi, Sishir, Olsen, Randall J., Leveque, Christopher, Schwartz, Mary R., Dey, Monisha, Chavez-East, Cheryl, Rogers, John, Shehabeldin, Ahmed, Joseph, David, Williams, Guy, Thomas, Karen, Masud, Faisal, Talley, Christina, Dlouhy, Katharine G., Lopez, Bevin V., Hampton, Curt, Lavinder, Jason, Gollihar, Jimmy D., Maranhao, Andre C., Ippolito, Gregory C., Saavedra, Matthew O., Cantu, Concepcion C., Yerramilli, Prasanti, Pruitt, Layne, Musser, James M.

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally, and no proven treatments are available…”
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Ferroptosis Affects the Progression of Nonalcoholic Steatohepatitis via the Modulation of Lipid Peroxidation–Mediated Cell Death in Mice by Qi, Jing, Kim, Jong-Won, Zhou, Zixiong, Lim, Chae-Woong, Kim, Bumseok

“…Oxidative stress and its associated lipid peroxidation play a key role in nonalcoholic steatohepatitis (NASH). Ferroptosis is a recently recognized type of…”
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Treatment of Coronavirus Disease 2019 Patients with Convalescent Plasma Reveals a Signal of Significantly Decreased Mortality by Salazar, Eric, Christensen, Paul A., Graviss, Edward A., Nguyen, Duc T., Castillo, Brian, Chen, Jian, Lopez, Bevin V., Eagar, Todd N., Yi, Xin, Zhao, Picheng, Rogers, John, Shehabeldin, Ahmed, Joseph, David, Leveque, Christopher, Olsen, Randall J., Bernard, David W., Gollihar, Jimmy, Musser, James M.

“…Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally, and proven treatments are limited…”
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Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration by Das, Amitava, Sinha, Mithun, Datta, Soma, Abas, Motaz, Chaffee, Scott, Sen, Chandan K, Roy, Sashwati

“…Heterogeneity and high versatility are the characteristic features of the cells of monocyte-macrophage lineage. The mononuclear phagocyte system, derived from…”
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Endoplasmic Reticulum Stress Signaling in Cancer Cells by Oakes, Scott A.

“…To survive, cancer cells must resist numerous internal and environmental insults associated with neoplasia that jeopardize proteostasis within the endoplasmic…”
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Association of Initial Viral Load in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients with Outcome and Symptoms by Argyropoulos, Kimon V., Serrano, Antonio, Hu, Jiyuan, Black, Margaret, Feng, Xiaojun, Shen, Guomiao, Call, Melissa, Kim, Min J., Lytle, Andrew, Belovarac, Brendan, Vougiouklakis, Theodore, Lin, Lawrence H., Moran, Una, Heguy, Adriana, Troxel, Andrea, Snuderl, Matija, Osman, Iman, Cotzia, Paolo, Jour, George

“…The dynamics of viral load (VL) of the severe acute respiratory syndrome coronavirus 2 and its association with different clinical parameters remain poorly…”
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The Dualistic Model of Ovarian Carcinogenesis: Revisited, Revised, and Expanded by Kurman, Robert J, Shih, Ie-Ming

“…Since our proposal of a dualistic model of epithelial ovarian carcinogenesis more than a decade ago, a large number of molecular and histopathologic studies…”
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Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor by Alexeev, Erica E., Lanis, Jordi M., Kao, Daniel J., Campbell, Eric L., Kelly, Caleb J., Battista, Kayla D., Gerich, Mark E., Jenkins, Brittany R., Walk, Seth T., Kominsky, Douglas J., Colgan, Sean P.

“…Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The…”
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Necroptosis in the Pathophysiology of Disease by Khoury, Mitri K., Gupta, Kartik, Franco, Sarah R., Liu, Bo

“…Over the past 15 years, elegant studies have demonstrated that in certain conditions, programed cell death resembles necrosis and depends on a unique molecular…”
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Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG by Salazar, Eric, Christensen, Paul A., Graviss, Edward A., Nguyen, Duc T., Castillo, Brian, Chen, Jian, Lopez, Bevin V., Eagar, Todd N., Yi, Xin, Zhao, Picheng, Rogers, John, Shehabeldin, Ahmed, Joseph, David, Masud, Faisal, Leveque, Christopher, Olsen, Randall J., Bernard, David W., Gollihar, Jimmy, Musser, James M.

“…Coronavirus disease 2019 (COVID-19) convalescent plasma has emerged as a promising therapy and has been granted Emergency Use Authorization by the US Food and…”
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The Origin of Ovarian Cancer Species and Precancerous Landscape by Shih, Ie-Ming, Wang, Yeh, Wang, Tian-Li

“…Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian…”
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Acute Respiratory Distress in Aged, SARS-CoV-2–Infected African Green Monkeys but Not Rhesus Macaques by Blair, Robert V., Vaccari, Monica, Doyle-Meyers, Lara A., Roy, Chad J., Russell-Lodrigue, Kasi, Fahlberg, Marissa, Monjure, Chris J., Beddingfield, Brandon, Plante, Kenneth S., Plante, Jessica A., Weaver, Scott C., Qin, Xuebin, Midkiff, Cecily C., Lehmicke, Gabrielle, Golden, Nadia, Threeton, Breanna, Penney, Toni, Allers, Carolina, Barnes, Mary B., Pattison, Melissa, Datta, Prasun K., Maness, Nicholas J., Birnbaum, Angela, Fischer, Tracy, Bohm, Rudolf P., Rappaport, Jay

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of disease severity, ranging from asymptomatic infection to a life-threating…”
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Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression by Nighot, Meghali, Al-Sadi, Rana, Guo, Shuhong, Rawat, Manmeet, Nighot, Prashant, Watterson, Martin D., Ma, Thomas Y.

“…Lipopolysaccharides (LPSs) are a major component of the Gram-negative bacterial cell wall and play an important role in mediating intestinal inflammatory…”
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Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis by Zhou, Zhou, Ye, Ting Jie, DeCaro, Elizabeth, Buehler, Brian, Stahl, Zachary, Bonavita, Gregory, Daniels, Michael, You, Min

“…Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD+-dependent protein deacetylase, is implicated in the pathogenesis of alcoholic liver disease (ALD). However,…”
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Mechanisms of Endothelial Regeneration and Vascular Repair and Their Application to Regenerative Medicine by Evans, Colin E., Iruela-Arispe, M. Luisa, Zhao, You-Yang

“…Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid balance between the circulation and surrounding tissues and for…”
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Hypophysitis Secondary to Cytotoxic T-Lymphocyte-Associated Protein 4 Blockade: Insights into Pathogenesis from an Autopsy Series by Caturegli, Patrizio, Di Dalmazi, Giulia, Lombardi, Martina, Grosso, Federica, Larman, H Benjamin, Larman, Tatianna, Taverna, Giacomo, Cosottini, Mirco, Lupi, Isabella

“…Hypophysitis that develops in cancer patients treated with monoclonal antibodies blocking cytotoxic T-lymphocyte-associated protein 4 (CTLA-4; an inhibitory…”
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Endothelial Cell Calcium Signaling during Barrier Function and Inflammation by Dalal, Prarthana J., Muller, William A., Sullivan, David P.

“…Calcium is an essential second messenger in endothelial cells and plays a pivotal role in regulating a number of physiologic processes, including cell…”
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