Search Results - "The AAPS journal"

Cancer Immunotherapy Update: FDA-Approved Checkpoint Inhibitors and Companion Diagnostics by Twomey, Julianne D., Zhang, Baolin

“…Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many cancer indications. This review provides an update on ICIs approved by…”
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Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects by Zu, Hui, Gao, Danchen

“…Gene therapy has been experiencing a breakthrough in recent years, targeting various specific cell groups in numerous therapeutic areas. However, most recent…”
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Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19 by Majumder, Joydeb, Minko, Tamara

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious…”
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Deep Learning for Drug Design: an Artificial Intelligence Paradigm for Drug Discovery in the Big Data Era by Jing, Yankang, Bian, Yuemin, Hu, Ziheng, Wang, Lirong, Xie, Xiang-Qun Sean

“…Over the last decade, deep learning (DL) methods have been extremely successful and widely used to develop artificial intelligence (AI) in almost every domain,…”
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Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications by Jeyaram, Anjana, Jay, Steven M.

“…Recently, extracellular vesicles (EVs)—including exosomes, microvesicles, and others—have attracted interest as cell-derived biotherapeutics and drug delivery…”
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A Review of Clinical Translation of Inorganic Nanoparticles by Anselmo, Aaron C., Mitragotri, Samir

“…Inorganic nanoparticles are widely used for therapeutic and diagnostic purposes as they offer unique features as compared with their organic and polymeric…”
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Drug Delivery Approaches in Addressing Clinical Pharmacology-Related Issues: Opportunities and Challenges by Wen, Hong, Jung, Huijeong, Li, Xuhong

“…Various drug delivery approaches can be used to maximize therapeutic efficacy and minimize side effects, by impacting absorption, distribution, metabolism, and…”
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Strategic Approaches to Optimizing Peptide ADME Properties by Di, Li

“…Development of peptide drugs is challenging but also quite rewarding. Five blockbuster peptide drugs are currently on the market, and six new peptides received…”
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Role of the Breast Cancer Resistance Protein (BCRP/ABCG2) in Drug Transport—an Update by Mao, Qingcheng, Unadkat, Jashvant D.

“…The human breast cancer resistance protein (BCRP, gene symbol ABCG2 ) is an ATP-binding cassette (ABC) efflux transporter. It was so named because it was…”
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Understanding Pharmaceutical Quality by Design by Yu, Lawrence X., Amidon, Gregory, Khan, Mansoor A., Hoag, Stephen W., Polli, James, Raju, G. K., Woodcock, Janet

“…This review further clarifies the concept of pharmaceutical quality by design (QbD) and describes its objectives. QbD elements include the following: (1) a…”
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Therapeutic Potential of Engineered Extracellular Vesicles by Mentkowski, Kyle I., Snitzer, Jonathan D., Rusnak, Sarah, Lang, Jennifer K.

“…Extracellular vesicles (EVs) comprise a heterogeneous group of small membrane vesicles, including exosomes, which play a critical role in intracellular…”
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Machine Learning and Artificial Intelligence in Pharmaceutical Research and Development: a Review by Kolluri, Sheela, Lin, Jianchang, Liu, Rachael, Zhang, Yanwei, Zhang, Wenwen

“…Over the past decade, artificial intelligence (AI) and machine learning (ML) have become the breakthrough technology most anticipated to have a transformative…”
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Exosomes for the Enhanced Tissue Bioavailability and Efficacy of Curcumin by Aqil, Farrukh, Munagala, Radha, Jeyabalan, Jeyaprakash, Agrawal, Ashish Kumar, Gupta, Ramesh

“…Exosomes are extracellular microvesicles with a particle size of 30–100 nm and carry a cargo of proteins, lipids, RNA, and DNA. Their properties of shuttling…”
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Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials by Gupta, Subash C., Patchva, Sridevi, Aggarwal, Bharat B.

“…Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric ( Curcuma longa ), can…”
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Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models by Bergstrand, Martin, Hooker, Andrew C., Wallin, Johan E., Karlsson, Mats O.

“…Informative diagnostic tools are vital to the development of useful mixed-effects models. The Visual Predictive Check (VPC) is a popular tool for evaluating…”
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Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit by Sun, Duxin

“…Remdesivir is one of the most promising drugs to treat COVID-19 based on the following facts: remdesivir has a broad-spectrum antiviral mechanism of action; it…”
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Therapeutic Applications of Curcumin Nanoformulations by Yallapu, Murali M., Nagesh, Prashanth K. Bhusetty, Jaggi, Meena, Chauhan, Subhash C.

“…Curcumin (diferuloylmethane) is a bioactive and major phenolic component of turmeric derived from the rhizomes of curcuma longa linn . For centuries, curcumin…”
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BDDCS Applied to Over 900 Drugs by Benet, Leslie Z., Broccatelli, Fabio, Oprea, Tudor I.

“…Here, we compile the Biopharmaceutics Drug Disposition Classification System (BDDCS) classification for 927 drugs, which include 30 active metabolites. Of the…”
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Ocular Drug Delivery by Gaudana, Ripal, Ananthula, Hari Krishna, Parenky, Ashwin, Mitra, Ashim K.

“…Ocular drug delivery has been a major challenge to pharmacologists and drug delivery scientists due to its unique anatomy and physiology. Static barriers…”
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Structure-Based Virtual Screening for Drug Discovery: a Problem-Centric Review by Cheng, Tiejun, Li, Qingliang, Zhou, Zhigang, Wang, Yanli, Bryant, Stephen H.

“…Structure-based virtual screening (SBVS) has been widely applied in early-stage drug discovery. From a problem-centric perspective, we reviewed the recent…”
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