Search Results - "Tharp, K"

Innate, non-cytolytic CD8+ T cell-mediated suppression of HIV replication by MHC-independent inhibition of virus transcription by Zanoni, Michelle, Palesch, David, Pinacchio, Claudia, Statzu, Maura, Tharp, Gregory K, Paiardini, Mirko, Chahroudi, Ann, Bosinger, Steven E, Yoon, Jack, Cox, Bryan, Silvestri, Guido, Kulpa, Deanna A

“…MHC-I-restricted, virus-specific cytotoxic CD8+ T cells (CTLs) may control human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV)…”
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The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention by Kelley, C F, Kraft, C S, de Man, T JB, Duphare, C, Lee, H-W, Yang, J, Easley, K A, Tharp, G K, Mulligan, M J, Sullivan, P S, Bosinger, S E, Amara, R R

“…Most HIV transmissions among men who have sex with men (MSM), the group that accounted for 67% of new US infections in 2014, occur via exposure to the rectal…”
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Antibiotic failure mediated by a resistant subpopulation in Enterobacter cloacae by Band, Victor I., Crispell, Emily K., Napier, Brooke A., Herrera, Carmen M., Tharp, Greg K., Vavikolanu, Kranthi, Pohl, Jan, Read, Timothy D., Bosinger, Steven E., Trent, M. Stephen, Burd, Eileen M., Weiss, David S.

“…Antibiotic resistance is a major public health threat, further complicated by unexplained treatment failures caused by bacteria that appear antibiotic…”
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BALDR: a computational pipeline for paired heavy and light chain immunoglobulin reconstruction in single-cell RNA-seq data by Upadhyay, Amit A, Kauffman, Robert C, Wolabaugh, Amber N, Cho, Alice, Patel, Nirav B, Reiss, Samantha M, Havenar-Daughton, Colin, Dawoud, Reem A, Tharp, Gregory K, Sanz, Iñaki, Pulendran, Bali, Crotty, Shane, Lee, F Eun-Hyung, Wrammert, Jens, Bosinger, Steven E

“…B cells play a critical role in the immune response by producing antibodies, which display remarkable diversity. Here we describe a bioinformatic pipeline,…”
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Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication by Nganou-Makamdop, Krystelle, Billingsley, James M, Yaffe, Zachary, O'Connor, Gregory, Tharp, Gregory K, Ransier, Amy, Laboune, Farida, Matus-Nicodemos, Rodrigo, Lerner, Andrea, Gharu, Lavina, Robertson, Jennifer M, Ford, Mandy L, Schlapschy, Martin, Kuhn, Nadine, Lensch, Alexandra, Lifson, Jeffrey, Nason, Martha, Skerra, Arne, Schreiber, Gideon, Bosinger, Steven E, Douek, Daniel C

“…Chronic activation of the immune system in HIV infection is one of the strongest predictors of morbidity and mortality. As such, approaches that reduce immune…”
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The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence by Strongin, Zachary, Hoang, Timothy N, Tharp, Gregory K, Rahmberg, Andrew R, Harper, Justin L, Nguyen, Kevin, Franchitti, Lavinia, Cervasi, Barbara, Lee, Max, Zhang, Zhan, Boritz, Eli A, Silvestri, Guido, Marconi, Vincent C, Bosinger, Steven E, Brenchley, Jason M, Kulpa, Deanna A, Paiardini, Mirko

“…Despite the advent of effective antiretroviral therapy (ART), human immunodeficiency virus (HIV) continues to pose major challenges, with extensive…”
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Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV by Mylvaganam, Geetha H, Chea, Lynette S, Tharp, Gregory K, Hicks, Sakeenah, Velu, Vijayakumar, Iyer, Smita S, Deleage, Claire, Estes, Jacob D, Bosinger, Steven E, Freeman, Gordon J, Ahmed, Rafi, Amara, Rama R

“…Therapeutic strategies that augment antiviral immunity and reduce the viral reservoir are critical to achieving durable remission of HIV. The coinhibitory…”
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Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention by Furlan, Scott N, Watkins, Benjamin, Tkachev, Victor, Flynn, Ryan, Cooley, Sarah, Ramakrishnan, Swetha, Singh, Karnail, Giver, Cindy, Hamby, Kelly, Stempora, Linda, Garrett, Aneesah, Chen, Jingyang, Betz, Kayla M, Ziegler, Carly G K, Tharp, Gregory K, Bosinger, Steven E, Promislow, Daniel E L, Miller, Jeffrey S, Waller, Edmund K, Blazar, Bruce R, Kean, Leslie S

“…Graft-versus-host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular…”
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Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells by McBrien, Julia Bergild, Mavigner, Maud, Franchitti, Lavinia, Smith, S. Abigail, White, Erick, Tharp, Gregory K., Walum, Hasse, Busman-Sahay, Kathleen, Aguilera-Sandoval, Christian R., Thayer, William O., Spagnuolo, Rae Ann, Kovarova, Martina, Wahl, Angela, Cervasi, Barbara, Margolis, David M., Vanderford, Thomas H., Carnathan, Diane G., Paiardini, Mirko, Lifson, Jeffrey D., Lee, John H., Safrit, Jeffrey T., Bosinger, Steven E., Estes, Jacob D., Derdeyn, Cynthia A., Garcia, J. Victor, Kulpa, Deanna A., Chahroudi, Ann, Silvestri, Guido

“…Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who receive antiretroviral therapy (ART) owing to a reservoir of latently…”
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The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies by Goll, Johannes B, Bosinger, Steven E, Jensen, Travis L, Walum, Hasse, Grimes, Tyler, Tharp, Gregory K, Natrajan, Muktha S, Blazevic, Azra, Head, Richard D, Gelber, Casey E, Steenbergen, Kristen J, Patel, Nirav B, Sanz, Patrick, Rouphael, Nadine G, Anderson, Evan J, Mulligan, Mark J, Hoft, Daniel F

“…Over the last decade, the field of systems vaccinology has emerged, in which high throughput transcriptomics and other omics assays are used to probe changes…”
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Corrigendum: The Vacc-SeqQC project: Benchmarking RNA-Seq for clinical vaccine studies by Goll, Johannes B, Bosinger, Steven E, Jensen, Travis L, Walum, Hasse, Grimes, Tyler, Tharp, Gregory K, Natrajan, Muktha S, Blazevic, Azra, Head, Richard D, Gelber, Casey E, Steenbergen, Kristen J, Patel, Nirav B, Sanz, Patrick, Rouphael, Nadine G, Anderson, Evan J, Mulligan, Mark J, Hoft, Daniel F

“…[This corrects the article DOI: 10.3389/fimmu.2022.1093242.]…”
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Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion by Joas, Simone, Sauermann, Ulrike, Roshani, Berit, Klippert, Antonina, Daskalaki, Maria, Mätz-Rensing, Kerstin, Stolte-Leeb, Nicole, Heigele, Anke, Tharp, Gregory K., Gupta, Prachi Mehrotra, Nelson, Sydney, Bosinger, Steven, Parodi, Laura, Giavedoni, Luis, Silvestri, Guido, Sauter, Daniel, Stahl-Hennig, Christiane, Kirchhoff, Frank

“…The inability of Nef to downmodulate the CD3-T cell receptor (TCR) complex distinguishes HIV-1 from other primate lentiviruses and may contribute to its high…”
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Genes located in a chromosomal inversion are correlated with territorial song in white‐throated sparrows by Zinzow‐Kramer, W. M., Horton, B. M., McKee, C. D., Michaud, J. M., Tharp, G. K., Thomas, J. W., Tuttle, E. M., Yi, S., Maney, D. L.

“…The genome of the white‐throated sparrow (Zonotrichia albicollis) contains an inversion polymorphism on chromosome 2 that is linked to predictable variation in…”
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Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIVmac239 in rhesus macaques by Laliberté, Alexandre, Prelli Bozzo, Caterina, Stahl-Hennig, Christiane, Hunszinger, Victoria, Joas, Simone, Sauermann, Ulrike, Roshani, Berit, Klippert, Antonina, Daskalaki, Maria, Mätz-Rensing, Kerstin, Stolte-Leeb, Nicole, Tharp, Gregory K., Fuchs, Dietmar, Gupta, Prachi Mehrotra, Silvestri, Guido, Nelson, Sydney A., Parodi, Laura, Giavedoni, Luis, Bosinger, Steven E., Sparrer, Konstantin M.J., Kirchhoff, Frank

“…The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces…”
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Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection by Rahman, Sheikh Abdul, Billingsley, James M, Sharma, Ashish Arunkumar, Styles, Tiffany M, Govindaraj, Sakthivel, Shanmugasundaram, Uma, Babu, Hemalatha, Riberio, Susan Pereira, Ali, Syed A, Tharp, Gregory K, Ibegbu, Chris, Waggoner, Stephen N, Johnson, R Paul, Sekaly, Rafick-Pierre, Villinger, Francois, Bosinger, Steve E, Amara, Rama Rao, Velu, Vijayakumar

“…The persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is a major barrier to an HIV/SIV cure. These reservoirs are…”
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Systems Analysis Reveals Contraceptive-Induced Alteration of Cervicovaginal Gene Expression in a Randomized Trial by Balle, Christina, Gupta, Prachi M, Tharp, Gregory K, Nelson, Sydney A, Konstantinus, Iyaloo N, Lennard, Katie, Jaumdally, Shameem Z, Happel, Anna-Ursula, Barnabas, Shaun L, Gill, Katherine, Bekker, Linda-Gail, Passmore, Jo-Ann S, Jaspan, Heather B, Bosinger, Steven E

“…Hormonal contraceptives (HCs) are vital in managing the reproductive health of women. However, HC usage has been linked to perturbations in cervicovaginal…”
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TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques by Upadhyay, Amit A., Viox, Elise G., Hoang, Timothy N., Boddapati, Arun K., Pino, Maria, Lee, Michelle Y.-H., Corry, Jacqueline, Strongin, Zachary, Cowan, David A., Beagle, Elizabeth N., Horton, Tristan R., Hamilton, Sydney, Aoued, Hadj, Harper, Justin L., Edwards, Christopher T., Nguyen, Kevin, Pellegrini, Kathryn L., Tharp, Gregory K., Piantadosi, Anne, Levit, Rebecca D., Amara, Rama R., Barratt-Boyes, Simon M., Ribeiro, Susan P., Sekaly, Rafick P., Vanderford, Thomas H., Schinazi, Raymond F., Paiardini, Mirko, Bosinger, Steven E.

“…The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2…”
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CABI Thesaurus by Tharp, Gregory K.

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The National Center for Education in Maternal and Child Health’s MCH Thesaurus by Tharp, Gregory K

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Intradermal but not intramuscular modified vaccinia Ankara immunizations protect against intravaginal tier2 simian-human immunodeficiency virus challenges in female macaques by Bollimpelli, Venkata S., Reddy, Pradeep B. J, Gangadhara, Sailaja, Charles, Tysheena P., Burton, Samantha L., Tharp, Gregory K., Styles, Tiffany M., Labranche, Celia C., Smith, Justin C., Upadhyay, Amit A., Sahoo, Anusmita, Legere, Traci, Shiferaw, Ayalnesh, Velu, Vijayakumar, Yu, Tianwei, Tomai, Mark, Vasilakos, John, Kasturi, Sudhir P., Shaw, George M., Montefiori, David, Bosinger, Steven E., Kozlowski, Pamela A., Pulendran, Bali, Derdeyn, Cynthia A., Hunter, Eric, Amara, Rama R.

“…Route of immunization can markedly influence the quality of immune response. Here, we show that intradermal (ID) but not intramuscular (IM) modified vaccinia…”
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