Search Results - "Tharmalingam, Bowranigan"
-
1
Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
Published in eLife (09-02-2018)“…The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation, however, the underlying mechanisms remain obscure. Our genome-wide…”
Get full text
Journal Article -
2
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
Published in Nature communications (08-05-2020)“…Studies on macrophage gene expression have historically focused on events leading to RNA polymerase II recruitment and transcription initiation, whereas the…”
Get full text
Journal Article -
3
Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages
Published in Nature communications (23-11-2017)“…The glucocorticoid (GC) receptor (GR) suppresses inflammation by activating anti-inflammatory and repressing pro-inflammatory genes. GR-interacting protein-1…”
Get full text
Journal Article -
4
Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy
Published in The Journal of experimental medicine (04-01-2021)“…Macrophages (MФ) and microglia (MG) are critical in the pathogenesis of multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis…”
Get full text
Journal Article -
5
-
6
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression
Published in The Journal of immunology (1950) (01-05-2020)“…Abstract Studies on macrophage gene expression have historically focused on events leading to RNA polymerase II recruitment and transcription initiation…”
Get full text
Journal Article