Search Results - "Thankachan, Stephen"

A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia by Kaur, Satvinder, Wang, Joshua L., Ferrari, Loris, Thankachan, Stephen, Kroeger, Daniel, Venner, Anne, Lazarus, Michael, Wellman, Andrew, Arrigoni, Elda, Fuller, Patrick M., Saper, Clifford B.

“…The precise neural circuitry that mediates arousal during sleep apnea is not known. We previously found that glutamatergic neurons in the external lateral…”
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Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations by Kim, Tae, Thankachan, Stephen, McKenna, James T., McNally, James M., Yang, Chun, Choi, Jee Hyun, Chen, Lichao, Kocsis, Bernat, Deisseroth, Karl, Strecker, Robert E., Basheer, Radhika, Brown, Ritchie E., McCarley, Robert W.

“…Cortical gamma band oscillations (GBO, 30–80 Hz, typically ∼40 Hz) are involved in higher cognitive functions such as feature binding, attention, and working…”
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Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice by Thankachan, Stephen, Yang, Chun, Kastanenka, Ksenia V., Bacskai, Brian J., Gerashchenko, Dmitry

“…Non-invasive stimulation technologies are emerging as potential treatment options for a range of neurodegenerative disorders. Experimental evidence suggests…”
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Thalamic Reticular Nucleus Parvalbumin Neurons Regulate Sleep Spindles and Electrophysiological Aspects of Schizophrenia in Mice by Thankachan, Stephen, Katsuki, Fumi, McKenna, James T., Yang, Chun, Shukla, Charu, Deisseroth, Karl, Uygun, David S., Strecker, Robert E., Brown, Ritchie E., McNally, James M., Basheer, Radhika

“…The thalamic reticular nucleus (TRN) is implicated in schizophrenia pathology. However, it remains unclear whether alterations of TRN activity can account for…”
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Validation of an automated sleep spindle detection method for mouse electroencephalography by Uygun, David S, Katsuki, Fumi, Bolortuya, Yunren, Aguilar, David D, McKenna, James T, Thankachan, Stephen, McCarley, Robert W, Basheer, Radhika, Brown, Ritchie E, Strecker, Robert E, McNally, James M

“…Sleep spindles are abnormal in several neuropsychiatric conditions and have been implicated in associated cognitive symptoms. Accordingly, there is growing…”
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Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice by Kaur, Satvinder, Thankachan, Stephen, Begum, Suraiya, Liu, Meng, Blanco-Centurion, Carlos, Shiromani, Priyattam J

“…Ten years ago the sleep disorder narcolepsy was linked to the neuropeptide hypocretin (HCRT), also known as orexin. This disorder is characterized by excessive…”
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Optimization of real-time analysis of sleep-wake cycle in mice by Thankachan, Stephen, Gerashchenko, Andrei, Kastanenka, Ksenia V, Bacskai, Brian J, Gerashchenko, Dmitry

“…Studying the biology of sleep requires accurate and efficient assessment of the sleep stages. However, analysis of sleep-wake cycles in mice and other…”
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Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice by Liu, Meng, Thankachan, Stephen, Kaur, Satvinder, Begum, Suraiya, Blanco-Centurion, Carlos, Sakurai, Takeshi, Yanagisawa, Masashi, Neve, Rachael, Shiromani, Priyattam J.

“…Gene transfer has proven to be an effective neurobiological tool in a number of neurodegenerative diseases, but it is not known if it can correct a sleep…”
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Entrainment of temperature and activity rhythms to restricted feeding in orexin knock out mice by Kaur, Satvinder, Thankachan, Stephen, Begum, Suraiya, Blanco-Centurion, Carlos, Sakurai, Takeshi, Yanagisawa, Masashi, Shiromani, Priyattam J

“…Abstract Ablation of the SCN, an established circadian clock, does not abolish food entrainment, suggesting that the food-entrainable oscillator (FEO) must lie…”
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The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom? by Yang, Chun, Thankachan, Stephen, McCarley, Robert W, Brown, Ritchie E

“…Highlights • Cholinergic, GABA and glutamatergic neurons all affect cortical activation. • Cholinergic neurons suppress cortical delta activity and promote…”
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A general approach for engineering RTKs optically controlled with far-red light by Leopold, Anna V., Thankachan, Stephen, Yang, Chun, Gerashchenko, Dmitry, Verkhusha, Vladislav V.

“…Regulation of receptor tyrosine kinase (RTK) activity is necessary for studying cell signaling pathways in health and disease. We developed a generalized…”
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Corrigendum to ‘The menagerie of the basal forebrain: how many (neural) species are there, what do they look like, how do they behave and who talks to whom?’ [Curr Opin Neurobiol 2017, 44:159–166] by Yang, Chun, Thankachan, Stephen, McCarley, Robert W, Brown, Ritchie E

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Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli by McKenna, James T., Thankachan, Stephen, Uygun, David S., Shukla, Charu, McNally, James M., Schiffino, Felipe L., Cordeira, Joshua, Katsuki, Fumi, Zant, Janneke C., Gamble, Mackenzie C., Deisseroth, Karl, McCarley, Robert W., Brown, Ritchie E., Strecker, Robert E., Basheer, Radhika

“…The ability to rapidly arouse from sleep is important for survival. However, increased arousals in patients with sleep apnea and other disorders prevent…”
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Activity of Pontine Neurons during Sleep and Cataplexy in Hypocretin Knock-Out Mice by Thankachan, Stephen, Kaur, Satvinder, Shiromani, Priyattam J

“…Narcolepsy is a human sleep disorder resulting from the loss of neurons containing the neuropeptide orexin, also known as hypocretin. Cataplexy, which is a…”
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Movement- and behavioral state-dependent activity of pontine reticulospinal neurons by Thankachan, S, Fuller, P.M, Lu, J

“…Highlights ► Locomotor activity is modulated by supraspinal inputs. ► Stimulation of pontine reticular formation triggers locomotion in decerebrate animals. ►…”
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Juxtacellular Recording/Labeling Analysis of Physiological and Anatomical Characteristics of Rat Intergeniculate Leaflet Neurons by Thankachan, Stephen, Rusak, Benjamin

“…The thalamic intergeniculate leaflet (IGL) is involved in mediating effects of both photic and nonphotic stimuli on mammalian circadian rhythms. IGL neurons…”
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Hypocretin-2 Saporin Lesions of the Ventrolateral Periaquaductal Gray by Kaur, Satvinder, Thankachan, Stephen, Begum, Suraiya, Liu, Meng, Blanco-Centurion, Carlos, Shiromani, Priyattam J

“…Ten years ago the sleep disorder narcolepsy was linked to the neuropeptide hypocretin (HCRT), also known as orexin. This disorder is characterized by excessive…”
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The development of hypocretin deficiency in ataxin-hypocretin transgenic rats by Zhang, Shengwen, Lin, Ling, Kaur, Satvinder, Thankachan, Stephen, Blanco-Centurion, Carlos, Yanagisawa, Masashi, Mignot, Emmanuel, Shiromani, Priyattam J.

“…Narcolepsy is linked to a widespread loss of neurons containing the neuropeptide hypocretin (HCRT), also named orexin. A transgenic (TG) rat model has been…”
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Influence of hypnogenic brain areas on wakefulness- and rapid-eye-movement sleep-related neurons in the brainstem of freely moving cats by Mallick, Birendra N., Thankachan, Stephen, Islam, Fakhrul

“…Rapid‐eye‐movement (REM) sleep is normally preceded by non‐REM sleep; however, every non‐REM sleep episode is not followed by REM sleep. It has been proposed…”
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Role of wake inducing brain stem area on rapid eye movement sleep regulation in freely moving cats by Thankachan, Stephen, Islam, Fakhrul, Mallick, Birendra N.

“…Some of the characteristic symptoms associated with rapid eye movement (REM) sleep are opposite to, while some apparently resemble, those of wakefulness…”
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