Search Results - "Thanaraj, Thangavel Alphonse"

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes by Qaddoumi, Mohammad G., Alanbaei, Muath, Hammad, Maha M., Al Khairi, Irina, Cherian, Preethi, Channanath, Arshad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd, Abu-Farha, Mohamed, Abubaker, Jehad

“…Myeloperoxidase (MPO) is positively associated with obesity and diet-induced insulin resistance. Angiopoietin-like protein 6 (ANGPTL6) regulates metabolic…”
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Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population by Hebbar, Prashantha, Nizam, Rasheeba, Melhem, Motasem, Alkayal, Fadi, Elkum, Naser, John, Sumi Elsa, Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have…”
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Mitochondrial haplogroup J associated with higher risk of obesity in the Qatari population by Dashti, Mohammed, Alsaleh, Hussain, Rodriguez-Flores, Juan L., Eaaswarkhanth, Muthukrishnan, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Obesity, a major risk factor for metabolic disorders, is highly prevalent in Qatari population. Maternal transmission of obesity traits can be significant; for…”
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Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population by Hebbar, Prashantha, Abubaker, Jehad Ahmed, Abu-Farha, Mohamed, Alsmadi, Osama, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Channanath, Arshad, Iqbal, Rasheeba, Pitkaniemi, Janne, Tuomilehto, Jaakko, Sladek, Robert, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for…”
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Immunogenicity of BNT162b2 Vaccine in Patients with Inflammatory Bowel Disease on Infliximab Combination Therapy: A Multicenter Prospective Study by Shehab, Mohammad, Abu-Farha, Mohamed, Alrashed, Fatema, Alfadhli, Ahmad, Alotaibi, Khazna, Alsahli, Abdullah, Alphonse Thanaraj, Thangavel, Channanath, Arshad, Ali, Hamad, Abubaker, Jehad, Almulla, Fahd

“…Background: Vaccination is a promising strategy to protect vulnerable groups like inflammatory bowel disease (IBD) patients against COVID-19 and associated…”
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ASD: a bioinformatics resource on alternative splicing by Stamm, Stefan, Riethoven, Jean-Jack, Le Texier, Vincent, Gopalakrishnan, Chellappa, Kumanduri, Vasudev, Tang, Yesheng, Barbosa-Morais, Nuno L, Thanaraj, Thangavel Alphonse

“…Alternative splicing is an important regulatory mechanism of mammalian gene expression. The alternative splicing database (ASD) consortium is systematically…”
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Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies by Shehab, Mohammad, Alrashed, Fatema, Alfadhli, Ahmad, Alotaibi, Khazna, Alsahli, Abdullah, Mohammad, Hussain, Cherian, Preethi, Al-Khairi, Irina, Alphonse Thanaraj, Thangavel, Channanath, Arshad, Ali, Hamad, Abu-Farha, Mohamed, Abubaker, Jehad, Al-Mulla, Fahd

“…The immunogenicity of SARS-CoV-2 vaccines in patients with inflammatory bowel disease (IBD) on biologic therapies is not well studied. The goal of this study…”
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The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target by Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Qaddoumi, Mohammad G, Hashem, Anwar, Abubaker, Jehad, Al-Mulla, Fahd

“…The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at…”
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Impact of Diabetes in Patients Diagnosed With COVID-19 by Abu-Farha, Mohamed, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse, Kavalakatt, Sina, Ali, Hamad, Abdul Ghani, Mohammed, Abubaker, Jehad

“…COVID-19 is a disease caused by the coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), known as a highly contagious disease, currently…”
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The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19 by Bosso, Mira, Thanaraj, Thangavel Alphonse, Abu-Farha, Mohamed, Alanbaei, Muath, Abubaker, Jehad, Al-Mulla, Fahd

“…The mechanism for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection requires the binding of the virus to the angiotensin-converting enzyme…”
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SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population by Dashti, Mohammed, Al-Matrouk, Abdullah, Channanath, Arshad, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Organic anion transporting polypeptides (OATP), which are encoded by SLCO genes, participate in the hepatic elimination of drugs and xenobiotics. SLCO1B1 is an…”
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Predictive models to assess risk of type 2 diabetes, hypertension and comorbidity: machine-learning algorithms and validation using national health data from Kuwait—a cohort study by Farran, Bassam, Channanath, Arshad Mohamed, Behbehani, Kazem, Thanaraj, Thangavel Alphonse

“…Objective We build classification models and risk assessment tools for diabetes, hypertension and comorbidity using machine-learning algorithms on data from…”
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Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population by Eaaswarkhanth, Muthukrishnan, Pathak, Ajai K, Ongaro, Linda, Montinaro, Francesco, Hebbar, Prashantha, Alsmadi, Osama, Metspalu, Mait, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Recent studies have showed the diverse genetic architecture of the highly consanguineous populations inhabiting the Arabian Peninsula. Consanguinity coupled…”
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A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research by Ray, Ashwini Kumar, Priya, Anjali, Malik, Md. Zubbair, Thanaraj, Thangavel Alphonse, Singh, Alok Kumar, Mago, Payal, Ghosh, Chirashree, Shalimar, Tandon, Ravi, Chaturvedi, Rupesh

“…Cardiovascular disease (CVD) is a collective term for disorders of the heart and blood vessels. The molecular events and biochemical pathways associated with…”
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Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families by Hebbar, Prashantha, Nizam, Rasheeba, John, Sumi Elsa, Antony, Dinu, Dashti, Mohammad, Channanath, Arshad, Shaltout, Azza, Al-Khandari, Hessa, Koistinen, Heikki A., Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and lifelong dependency on exogenous…”
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Association between alleles, haplotypes, and amino acid variations in HLA class II genes and type 1 diabetes in Kuwaiti children by Dashti, Mohammed, Nizam, Rasheeba, Jacob, Sindhu, Al-Kandari, Hessa, Al Ozairi, Ebaa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is a complex autoimmune disorder that is highly prevalent globally. The interactions between genetic and environmental factors may…”
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HLA-B allele frequencies and implications for pharmacogenetics in the Kuwaiti population by Dashti, Mohammed, Malik, Md Zubbair, Al-Matrouk, Abdullah, Bhatti, Saeeda, Nizam, Rasheeba, Jacob, Sindhu, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…This study explores the frequency of human leukocyte antigen (HLA) genes, particularly alleles, within the Kuwaiti population. We aim to identify alleles with…”
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Investigating the Role of FABP4 in Diabetes and Obesity and the Influence of Age and Ethnicity: A Comprehensive Analysis of a Cohort from the KEDP-Study by Abdalla, Mohammed A, Abubaker, Jehad, Abu-Farha, Mohamed, Al-Khairi, Irina, Cherian, Preethi, Qaddoumi, Mohammad G, Al-Rashed, Fatema, Thanaraj, Thangavel Alphonse, Albatineh, Ahmed N, Al-Mulla, Fahd

“…Adipocyte P2 (aP2), also known as FABP4, is an adipokine that adipose tissue produces and expresses in macrophages. Its primary role is to facilitate the…”
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Differentially methylated and expressed genes in familial type 1 diabetes by Dashti, Mohammed, Nizam, Rasheeba, Hebbar, Prashantha, Jacob, Sindhu, John, Sumi Elsa, Channanath, Arshad, Al-Kandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…There has recently been a growing interest in examining the role of epigenetic modifications, such as DNA methylation, in the etiology of type 1 diabetes…”
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