Search Results - "Thambirajah, Anita A"

Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis by Thambirajah, Anita A, Koide, Emily M, Imbery, Jacob J, Helbing, Caren C

“…Aquatic and terrestrial environments are increasingly contaminated by anthropogenic sources that include pharmaceuticals, personal care products, and…”
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Corrigendum: Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis by Thambirajah, Anita A, Koide, Emily M, Imbery, Jacob J, Helbing, Caren C

“…[This corrects the article DOI: 10.3389/fendo.2019.00276.]…”
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Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity by Good, Katrina V., Martínez de Paz, Alexia, Tyagi, Monica, Cheema, Manjinder S., Thambirajah, Anita A., Gretzinger, Taylor L., Stefanelli, Gilda, Chow, Robert L., Krupke, Oliver, Hendzel, Michael, Missiaen, Kristal, Underhill, Alan, Landsberger, Nicoletta, Ausió, Juan

“…MeCP2 binds to methylated DNA in a chromatin context and has an important role in cancer and brain development and function. Histone deacetylase (HDAC)…”
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MeCP2 preferentially binds to methylated linker DNA in the absence of the terminal tail of histone H3 and independently of histone acetylation by Ishibashi, Toyotaka, Thambirajah, Anita A., Ausió, Juan

“…Methyl CpG binding protein 2 (MeCP2) is a basic protein that contains a DNA methyl binding domain. The mechanism by which the highly positive charge of MeCP2…”
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H2A.Z Stabilizes Chromatin in a Way That Is Dependent on Core Histone Acetylation by Thambirajah, Anita A., Dryhurst, Deanna, Ishibashi, Toyotaka, Li, Andra, Maffey, Allison H., Ausió, Juan

“…The functional and structural chromatin roles of H2A.Z are still controversial. This work represents a further attempt to resolve the current functional and…”
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Disruption by stealth - Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals by Thambirajah, Anita A., Wade, Michael G., Verreault, Jonathan, Buisine, Nicolas, Alves, Verônica A., Langlois, Valerie S., Helbing, Caren C.

“…Thyroid hormones (THs) are important regulators of growth, development, and homeostasis of all vertebrates. There are many environmental contaminants that are…”
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Dynamic cyp1a1 transcript responses in the caudal fin of coho salmon (Oncorhynchus kisutch) smolts to low sulfur marine diesel water accommodated fraction exposures and depuration by Thambirajah, Anita A., Miliano, Rachel C., Abbott, Ethan A., Buday, Craig, Shang, Dayue, Kwok, Honoria, Helbing, Caren C.

“…•Coho salmon smolts were exposed to marine diesel seawater accommodated fractions.•Cyp1a1 transcripts were more elevated in caudal fin than liver regardless of…”
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Comparison of transcriptome responses of the liver, tail fin, and olfactory epithelium of Rana [Lithobates] catesbeiana tadpoles disrupted by thyroid hormones and estrogen by Jackman, Shireen H., Evans, Ellis P., Kuecks-Winger, Haley N., Corrie, Lorissa M., Imbery, Jacob J., Miliano, Rachel C., Robert, Bonnie J., Thompson, Vanessa C., Thambirajah, Anita A., Lesperance, Mary L., Pyle, Gregory G., van Aggelen, Graham, Helbing, Caren C.

“…•Thyroid hormones (THs) are important in vertebrates and are contaminant targets.•Estradiol (E2) may crosstalk with thyroxine (T4) and triiodothyronine…”
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MeCP2 binds to nucleosome free (linker DNA) regions and to H3K9/H3K27 methylated nucleosomes in the brain by Thambirajah, Anita A, Ng, Marlee K, Frehlick, Lindsay J, Li, Andra, Serpa, Jason J, Petrotchenko, Evgeniy V, Silva-Moreno, Begonia, Missiaen, Kristal K, Borchers, Christoph H, Adam Hall, J, Mackie, Ryan, Lutz, Frank, Gowen, Brent E, Hendzel, Michael, Georgel, Philippe T, Ausió, Juan

“…Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-binding protein that mediates transcriptional regulation, and is highly abundant in brain. The nature of…”
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A nitrifier‐enriched microbial community contributes to the degradation of environmental DNA by Beattie, Rachelle E., Helbing, Caren C., Imbery, Jacob J., Klymus, Katy E., Lopez Duran, Jonathan, Richter, Catherine A., Thambirajah, Anita A., Thompson, Nathan, Edwards, Thea M.

“…Environmental DNA (eDNA) surveys are a promising alternative to traditional monitoring of invasive species, rare species, and biodiversity. Detecting…”
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New developments in post-translational modifications and functions of histone H2A variants by Thambirajah, Anita A, Li, Andra, Ishibashi, Toyotaka, Ausió, Juan

“…Structural variability within histone families, such as H2A, can be achieved through 2 primary mechanisms: the expression of histone variants and the…”
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MeCP2 post-translational regulation through PEST domains: two novel hypotheses: potential relevance and implications for Rett syndrome by Thambirajah, Anita A, Eubanks, James H, Ausió, Juan

“…Mutations in the methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome, a severe neurodevelopmental disease associated with ataxia and other post-natal…”
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MeCP2 post-translational regulation through PEST domains: two novel hypotheses by Thambirajah, Anita A., Eubanks, James H., Ausió, Juan

“…Mutations in the methyl‐CpG‐binding protein 2 (MeCP2) cause Rett syndrome, a severe neurodevelopmental disease associated with ataxia and other post‐natal…”
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A moment's pause: putative nucleosome-based influences on MeCP2 regulation by Thambirajah, Anita A, Ausió, Juan

“…There has been a hotbed of activity surrounding MeCP2 research in the past number of years. Despite better characterizing the functions and nature of this…”
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Beyond the Xi: macroH2A chromatin distribution and post-translational modification in an avian system by Abbott, D Wade, Chadwick, Brian P, Thambirajah, Anita A, Ausió, Juan

“…MacroH2A (mH2A) is a histone variant that is enriched in the inactivated X-chromosomes of mammalian females. To characterize the role of this protein in other…”
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New twists on H2A.Z: a histone variant with a controversial structural and functional past by Dryhurst, Deanna, Thambirajah, Anita A, Ausió, Juan

“…Integration of histone variants into chromatin organization allows for functional specification of chromatin regions. Recent functional analyses of H2A.Z have…”
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Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls by Thambirajah, Anita A, Sleigh, Kenna, Stiver, H Grant, Chow, Anthony W

“…Since physical exertion is known to exacerbate the symptoms of chronic fatigue syndrome (CFS) and metabolic changes and including oxidative stress can modulate…”
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Binding of Antitumor Antibiotic Daunomycin to Histones in Chromatin and in Solution by Rabbani, Azra, Finn, Ron M, Thambirajah, Anita A, Ausió, Juan

“…Daunomycin is an anticancer drug that is well-known to interact with DNA in chromatin. Using a compositionally defined chicken erythrocyte chromatin fraction,…”
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Beyond the Xi by Abbott, D. Wade, Chadwick, Brian P., Thambirajah, Anita A., Ausió, Juan

“…MacroH2A (mH2A) is a histone variant that is enriched in the inactivated X-chromosomes of mammalian females. To characterize the role of this protein in other…”
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