Search Results - "Thalji, Reema"

Enantioselective Intramolecular Hydroarylation of Alkenes via Directed C−H Bond Activation by Harada, Hitoshi, Thalji, Reema K, Bergman, Robert G, Ellman, Jonathan A

“…Highly enantioselective catalytic intramolecular ortho-alkylation of aromatic imines containing alkenyl groups tethered at the meta position relative to the…”
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Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase by Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.

“…A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gramnegative hospital…”
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Structure-guided design of antibacterials that allosterically inhibit DNA gyrase by Thalji, Reema K., Raha, Kaushik, Andreotti, Daniele, Checchia, Anna, Cui, Haifeng, Meneghelli, Giovanni, Profeta, Roberto, Tonelli, Federica, Tommasi, Simona, Bakshi, Tania, Donovan, Brian T., Howells, Alison, Jain, Shruti, Nixon, Christopher, Quinque, Geoffrey, McCloskey, Lynn, Bax, Benjamin D., Neu, Margarete, Chan, Pan F., Stavenger, Robert A.

“…[Display omitted] A series of DNA gyrase inhibitors were designed based on the X-ray structure of a parent thiophene scaffold with the objective to improve…”
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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement by Barton, Linda S., Callahan, James F., Cantizani, Juan, Concha, Nestor O., Cotillo Torrejon, Ignacio, Goodwin, Nicole C., Joshi-Pangu, Amruta, Kiesow, Terry J., McAtee, Jeff J., Mellinger, Mark, Nixon, Christopher J., Padrón-Barthe, Laura, Patterson, Jaclyn R., Pearson, Neil D., Pouliot, Jeffrey J., Rendina, Alan R., Buitrago Santanilla, Alexander, Schneck, Jessica L., Sanz, Olalla, Thalji, Reema K., Ward, Paris, Williams, Shawn P., King, Bryan W.

“…[Display omitted] •P1 analogues with aldehyde warhead prepared and tested against 3CLpro in SARS-CoV-2.•Discovery of 2-THF as P1 residue with potent inhibition…”
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Highly Efficient and Enantioselective Cyclization of Aromatic Imines via Directed C−H Bond Activation by Thalji, Reema K, Ellman, Jonathan A, Bergman, Robert G

“…The first highly enantioselective catalytic reaction involving aromatic C−H bond activation is communicated. Enantioselective cyclization of aromatic ketimines…”
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Enantioselective Synthesis of a PKC Inhibitor via Catalytic C−H Bond Activation by Wilson, Rebecca M, Thalji, Reema K, Bergman, Robert G, Ellman, Jonathan A

“…The syntheses of two biologically active molecules possessing dihydropyrroloindole cores (1 and 2) were completed using rhodium-catalyzed imine-directed C−H…”
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Remarkable Phosphine-Effect on the Intramolecular Aldol Reactions of Unsaturated 1,5-Diketones:  Highly Regioselective Synthesis of Cross-Conjugated Dienones by Thalji, Reema K, Roush, William R

“…We report a phosphine-mediated intramolecular aldol cyclization of unsaturated diketones that proceeds with extremely high levels of regioselectivity for the…”
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Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase by Thalji, Reema K., McAtee, Jeff J., Belyanskaya, Svetlana, Brandt, Martin, Brown, Gregory D., Costell, Melissa H., Ding, Yun, Dodson, Jason W., Eisennagel, Steve H., Fries, Rusty E., Gross, Jeffrey W., Harpel, Mark R., Holt, Dennis A., Israel, David I., Jolivette, Larry J., Krosky, Daniel, Li, Hu, Lu, Quinn, Mandichak, Tracy, Roethke, Theresa, Schnackenberg, Christine G., Schwartz, Benjamin, Shewchuk, Lisa M., Xie, Wensheng, Behm, David J., Douglas, Stephen A., Shaw, Ami L., Marino, Joseph P.

“…1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library…”
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Soluble epoxide hydrolase inhibition exerts beneficial anti-remodeling actions post-myocardial infarction by Kompa, Andrew R, Wang, Bing H, Xu, Guoying, Zhang, Yuan, Ho, Pei-Yu, Eisennagel, Stephen, Thalji, Reema K, Marino, Joseph P, Kelly, Darren J, Behm, David J, Krum, Henry

“…Abstract Background A contributory role for soluble epoxide hydrolase (sEH) in cardiac remodeling post-myocardial infarction (MI) has been suggested; however…”
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Annulation of Aromatic Imines via Directed C−H Bond Activation by Thalji, Reema K, Ahrendt, Kateri A, Bergman, Robert G, Ellman, Jonathan A

“…A directed C−H bond activation approach to the synthesis of indans, tetralins, dihydrofurans, dihydroindoles, and other polycyclic aromatic compounds is…”
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Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists by Thalji, Reema K, Aiyar, Nambi, Davenport, Elizabeth A, Erhardt, Joseph A, Kallal, Lorena A, Morrow, Dwight M, Senadhi, Shobha, Burns-Kurtis, Cynthia L, Marino, Jr, Joseph P

“…Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the…”
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Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors by Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng

“…A novel series of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones have been synthesized as potent and selective checkpoint kinase 1 (Chk1) inhibitors via…”
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Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists by MORALES-RAMOS, Angel I, MECOM, John S, LONDREGAN, Allyn T, MORROW, Dwight M, SENADHI, Shobha, THALJI, Reema K, ZHAO, Steve, BURNS-KURTIS, Cynthia L, MARINO, Joseph P, KIESOW, Terry J, GRAYBILL, Todd L, BROWN, Gregory D, AIYAR, Nambi V, DAVENPORT, Elizabeth A, KALLAL, Lorena A, KNAPP-REED, Beth A, PENG LI

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Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists by Morales-Ramos, Angel I, Mecom, John S, Kiesow, Terry J, Graybill, Todd L, Brown, Gregory D, Aiyar, Nambi V, Davenport, Elizabeth A, Kallal, Lorena A, Knapp-Reed, Beth A, Li, Peng, Londregan, Allyn T, Morrow, Dwight M, Senadhi, Shobha, Thalji, Reema K, Zhao, Steve, Burns-Kurtis, Cynthia L, Marino, Jr, Joseph P

“…High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists…”
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Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists by Thalji, Reema K., Aiyar, Nambi, Davenport, Elizabeth A., Erhardt, Joseph A., Kallal, Lorena A., Morrow, Dwight M., Senadhi, Shobha, Burns-Kurtis, Cynthia L., Marino, Joseph P.

“…Benzofuran-substituted urea analogs have been identified as novel P2Y1 receptor antagonists. Structure–activity relationship studies around the urea and the…”
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Fluorescence of cis-1-Amino-2-(3-indolyl)cyclohexane-1-carboxylic Acid:  A Single Tryptophan χ1 Rotamer Model by Liu, Bo, Thalji, Reema K, Adams, Paul D, Fronczek, Frank R, McLaughlin, Mark L, Barkley, Mary D

“…A constrained derivative, cis-1-amino-2-(3-indolyl)cyclohexane-1-carboxylic acid, cis-W3, was designed to test the rotamer model of tryptophan photophysics…”
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Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening by Tian, Xinrong, Suarez, Dominic, Thomson, Douglas, Li, William, King, Elizabeth A., LaFrance, Louis, Boehm, Jeffrey, Barton, Linda, Di Marco, Christina, Martyr, Cuthbert, Thalji, Reema, Medina, Jesus, Knight, Steven, Heerding, Dirk, Gao, Enoch, Nartey, Eldridge, Cecconie, Ted, Nixon, Christopher, Zhang, Guofeng, Berrodin, Thomas J., Phelps, Christopher, Patel, Amish, Bai, Xiaopeng, Lind, Ken, Prabhu, Ninad, Messer, Jeffrey, Zhu, Zhengrong, Shewchuk, Lisa, Reid, Rob, Graves, Alan P., McHugh, Charles, Mangatt, Biju

“…E1A binding protein (p300) and CREB binding protein (CBP) are two highly homologous and multidomain histone acetyltransferases. These two proteins are involved…”
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Benzofuran-substituted urea derivatives as novel P2Y sub(1) receptor antagonists by Thalji, Reema K, Aiyar, Nambi, Davenport, Elizabeth A, Erhardt, Joseph A, Kallal, Lorena A, Morrow, Dwight M, Senadhi, Shobha, Burns-Kurtis, Cynthia L

“…Benzofuran-substituted urea analogs have been identified as novel P2Y sub(1) receptor antagonists. Structure-activity relationship studies around the urea and…”
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Enantioselective Synthesis of a PKC Inhibitor via Catalytic C-HBond Activation by Wilson, Rebecca M., Thalji, Reema K., Bergman, Robert G., Ellman,Jonathan A.

“…The syntheses of two biologically active molecules possessing dihydropyrroloindole cores (1 and 2) were completed using rhodium-catalyzed imine-directed C-H…”
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Highly efficient and enantioselective cyclization of aromatic imines via directed C-H bond activation by Thalji, Reema K., Ellman, Jonathan A., Bergman, Robert G.

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