Search Results - "Thalhamer, Josef"

Influence of protein fold stability on immunogenicity and its implications for vaccine design by Scheiblhofer, Sandra, Laimer, Josef, Machado, Yoan, Weiss, Richard, Thalhamer, Josef

“…In modern vaccinology and immunotherapy, recombinant proteins more and more replace whole organisms to induce protective or curative immune responses…”
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DNA and mRNA vaccination against allergies by Scheiblhofer, Sandra, Thalhamer, Josef, Weiss, Richard

“…Allergen‐specific immunotherapy, which is performed by subcutaneous injection or sublingual application of allergen extracts, represents an effective treatment…”
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Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy by Focke-Tejkl, Margarete, PhD, Weber, Milena, MSc, Niespodziana, Katarzyna, PhD, Neubauer, Angela, PhD, Huber, Hans, PhD, Henning, Rainer, PhD, Stegfellner, Gottfried, MSc, Maderegger, Bernhard, PhD, Hauer, Martina, MSc, Stolz, Frank, PhD, Niederberger, Verena, MD, Marth, Katharina, MD, Eckl-Dorna, Julia, MD, PhD, Weiss, Richard, PhD, Thalhamer, Josef, PhD, Blatt, Katharina, MSc, Valent, Peter, MD, Valenta, Rudolf, MD

“…Background Grass pollen is one of the most important sources of respiratory allergies worldwide. Objective This study describes the development of a grass…”
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Skin vaccination via fractional infrared laser ablation - Optimization of laser-parameters and adjuvantation by Scheiblhofer, Sandra, Strobl, Anna, Hoepflinger, Veronika, Thalhamer, Theresa, Steiner, Martin, Thalhamer, Josef, Weiss, Richard

“…Abstract Background Methods to deliver an antigen into the skin in a painless, defined, and reproducible manner are essential for transcutaneous immunization…”
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Neoantigen Expression in Steady-State Langerhans Cells Induces CTL Tolerance by Strandt, Helen, Pinheiro, Douglas Florindo, Kaplan, Daniel H, Wirth, Dagmar, Gratz, Iris Karina, Hammerl, Peter, Thalhamer, Josef, Stoecklinger, Angelika

“…The skin hosts a variety of dendritic cells (DCs), which act as professional APC to control cutaneous immunity. Langerhans cells (LCs) are the only DC subset…”
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Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen by Machado, Yoan, MSc, Freier, Regina, MSc, Scheiblhofer, Sandra, PhD, Thalhamer, Theresa, PhD, Mayr, Melissa, BSc, Briza, Peter, PhD, Grutsch, Sarina, PhD, Ahammer, Linda, MSc, Fuchs, Julian E., PhD, Wallnoefer, Hannes G., PhD, Isakovic, Almedina, MSc, Kohlbauer, Vera, MSc, Hinterholzer, Arthur, BSc, Steiner, Markus, MSc, Danzer, Martin, MSc, Horejs-Hoeck, Jutta, PhD, Ferreira, Fatima, PhD, Liedl, Klaus R., PhD, Tollinger, Martin, PhD, Lackner, Peter, PhD, Johnson, Christopher M., PhD, Brandstetter, Hans, PhD, Thalhamer, Josef, PhD, Weiss, Richard, PhD

“…Background The search for intrinsic factors, which account for a protein's capability to act as an allergen, is ongoing. Fold stability has been identified as…”
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Generation and Evaluation of Prophylactic mRNA Vaccines Against Allergy by Weiss, Richard, Scheiblhofer, Sandra, Thalhamer, Josef

“…Due to the worldwide increase in allergies and a limited efficacy of therapeutic interventions, the need for prophylactic vaccination against allergies has…”
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Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy by Machado, Yoan, Duinkerken, Sanne, Hoepflinger, Veronika, Mayr, Melissa, Korotchenko, Evgeniia, Kurtaj, Almedina, Pablos, Isabel, Steiner, Markus, Stoecklinger, Angelika, Lübbers, Joyce, Schmid, Maximillian, Ritter, Uwe, Scheiblhofer, Sandra, Ablinger, Michael, Wally, Verena, Hochmann, Sarah, Raninger, Anna M., Strunk, Dirk, van Kooyk, Yvette, Thalhamer, Josef, Weiss, Richard

“…Due to its unique immunological properties, the skin is an attractive target tissue for allergen-specific immunotherapy. In our current work, we combined a…”
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Flexible IgE epitope containing domains of Phl p 5 cause high allergenic activity by Göbl, Christoph, PhD, Focke-Tejkl, Margarete, PhD, Najafi, Nazanin, MSc, Schrank, Evelyne, PhD, Madl, Tobias, PhD, Kosol, Simone, PhD, Madritsch, Christoph, PhD, Dorofeeva, Yulia, MD, Flicker, Sabine, PhD, Thalhamer, Josef, PhD, Valenta, Rudolf, MD, Zangger, Klaus, PhD, Tjandra, Nico, PhD

“…Summary This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on…”
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Transcutaneous delivery of CpG-adjuvanted allergen via laser-generated micropores by Hessenberger, Michael, Weiss, Richard, Weinberger, Esther E, Boehler, Christof, Thalhamer, Josef, Scheiblhofer, Sandra

“…Highlights ► Laser-assisted transcutaneous immunotherapy is equally efficient as classical SCIT. ► TCIT is a painless alternative to SCIT for the treatment of…”
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Molecular and immunological characterization of Tri a 36, a low molecular weight glutenin, as a novel major wheat food allergen by Baar, Alexandra, Pahr, Sandra, Constantin, Claudia, Scheiblhofer, Sandra, Thalhamer, Josef, Giavi, Stavroula, Papadopoulos, Nikolaos G, Ebner, Christof, Mari, Adriano, Vrtala, Susanne, Valenta, Rudolf

“…Wheat is an essential element in our nutrition but one of the most important food allergen sources. Wheat allergic patients often suffer from severe…”
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Immunize and disappear—Safety-optimized mRNA vaccination with a panel of 29 allergens by Roesler, Elisabeth, MSc, Weiss, Richard, PhD, Weinberger, Esther E., MSc, Fruehwirth, Angelika, MSc, Stoecklinger, Angelika, PhD, Mostböck, Sven, PhD, Ferreira, Fatima, PhD, Thalhamer, Josef, PhD, Scheiblhofer, Sandra, PhD

“…Background The spread of type I allergic diseases has reached epidemic dimensions. The success of therapeutic intervention is limited, and hence prophylactic…”
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α-Purothionin, a new wheat allergen associated with severe allergy by Pahr, Sandra, MSc, Constantin, Claudia, PhD, Papadopoulos, Nikolaos G., MD, PhD, Giavi, Stavroula, MD, Mäkelä, Mika, MD, PhD, Pelkonen, Anna, MD, PhD, Ebner, Christof, MD, Mari, Adriano, MD, Scheiblhofer, Sandra, PhD, Thalhamer, Josef, PhD, Kundi, Michael, MD, PhD, Vrtala, Susanne, PhD, Mittermann, Irene, PhD, Valenta, Rudolf, MD

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Immune Reactions against Gene Gun Vaccines Are Differentially Modulated by Distinct Dendritic Cell Subsets in the Skin by Weber, Corinna Stefanie, Hainz, Katrina, Deressa, Tekalign, Strandt, Helen, Florindo Pinheiro, Douglas, Mittermair, Roberta, Pizarro Pesado, Jennifer, Thalhamer, Josef, Hammerl, Peter, Stoecklinger, Angelika

“…The skin accommodates multiple dendritic cell (DC) subsets with remarkable functional diversity. Immune reactions are initiated and modulated by the triggering…”
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Reshaping the Bet v 1 fold modulates TH polarization by Wallner, Michael, PhD, Hauser, Michael, PhD, Himly, Martin, PhD, Zaborsky, Nadja, PhD, Mutschlechner, Sonja, PhD, Harrer, Andrea, PhD, Asam, Claudia, MSc, Pichler, Ulrike, MSc, van Ree, Ronald, PhD, Briza, Peter, PhD, Thalhamer, Josef, PhD, Bohle, Barbara, PhD, Achatz, Gernot, PhD, Ferreira, Fatima, PhD

“…Background Several alternative mechanisms have been proposed to explain why some proteins are able to induce a TH 2-biased and IgE-mediated immune response…”
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No Concentration Decrease of House Dust Mite Allergens With Rising Altitude in Alpine Regions by Grafetstätter, Carina, Prossegger, Johanna, Braunschmid, Herbert, Sanovic, Renata, Hahne, Penelope, Pichler, Christina, Thalhamer, Josef, Hartl, Arnulf

“…Several studies over the past 4 decades have indicated a significant reduction in house dust mite (HDM) and HDM allergen concentration in areas higher than…”
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Staphylococcus aureus fibronectin-binding protein specifically binds IgE from patients with atopic dermatitis and requires antigen presentation for cellular immune responses by Reginald, Kavita, PhD, Westritschnig, Kerstin, MD, Linhart, Birgit, PhD, Focke-Tejkl, Margarete, PhD, Jahn-Schmid, Beatrice, PhD, Eckl-Dorna, Julia, MD, PhD, Heratizadeh, Annice, MD, Stöcklinger, Angelika, PhD, Balic, Nadja, Spitzauer, Susanne, MD, Niederberger, Verena, MD, Werfel, Thomas, MD, Thalhamer, Josef, PhD, Weidinger, Stephan, MD, Novak, Natalija, MD, Ollert, Markus, MD, Hirschl, Alexander M., MD, Valenta, Rudolf, MD

“…Background Staphylococcus aureus superinfections occur in more than 90% of patients with atopic dermatitis (AD) and aggravate skin inflammation. S aureus…”
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Molecular and Immunological Characterization of Gamma Gliadins As Major Allergens in Wheat Food Allergy by Wieser, Sandra, PhD, Baar, Alexandra, PhD, Srinivasan, Bharani, PhD, Papadopoulos, Nikolaos G., MD, FAAAAI, Giavi, Stavroula, MD, PhD, Makela, Mika, MD, PhD, Pelkonen, Anna, MD, PhD, Ebner, Christof, MD, Thalhamer, Josef, PhD, Vrtala, Susanne, PhD, Valenta, Rudolf, MD

“…Immunodominant IgE epitopes were identified on the N-terminus indicating that IgE recognition does not require fold and is directed against linear epitopes…”
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Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening by Thalhamer, Theresa, PhD, Dobias, Heidi, MSc, Stepanoska, Tatjana, PhD, Pröll, Martina, PhD, Stutz, Hanno, PhD, Dissertori, Oliver, MSc, Lackner, Peter, PhD, Ferreira, Fatima, PhD, Wallner, Michael, PhD, Thalhamer, Josef, PhD, Hartl, Arnulf, PhD

“…Background The incidence of allergic diseases in developed countries has been increasing constantly in the last 2 decades. The only curative treatment…”
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Molecular and Immunological Characterization of a Wheat Serine Proteinase Inhibitor as a Novel Allergen in Baker's Asthma by Constantin, Claudia, Quirce, Santiago, Grote, Monika, Touraev, Alisher, Swoboda, Ines, Stoecklinger, Angelika, Mari, Adriano, Thalhamer, Josef, Heberle-Bors, Erwin, Valenta, Rudolf

“…IgE-mediated sensitization to wheat flour belongs to the most frequent causes of occupational asthma. A cDNA library from wheat seeds was constructed and…”
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