Search Results - "Thaler, Avner"

The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): a prospective longitudinal study protocol by Bregman, Noa, Shiner, Tamara, Kavé, Gitit, Alcalay, Roy, Gana-Weisz, Mali, Goldstein, Orly, Glinka, Tal, Aizenstein, Orna, Bashat, Dafna Ben, Alcalay, Yifat, Mirelman, Anat, Thaler, Avner, Giladi, Nir, Omer, Nurit

“…Creutzfeldt-Jakob Disease (CJD) is the most common prion disease in humans causing a rapidly progressive neurological decline and dementia and is invariably…”
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Editorial: Updates on inflammation in Parkinson's disease by Dzamko, Nicolas, Romero-Ramos, Marina, Thaler, Avner

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Detecting Sensitive Mobility Features for Parkinson's Disease Stages Via Machine Learning by Mirelman, Anat, Ben Or Frank, Mor, Melamed, Michal, Granovsky, Lena, Nieuwboer, Alice, Rochester, Lynn, Del Din, Silvia, Avanzino, Laura, Pelosin, Elisa, Bloem, Bastiaan R., Della Croce, Ugo, Cereatti, Andrea, Bonato, Paolo, Camicioli, Richard, Ellis, Theresa, Hamilton, Jamie L., Hass, Chris J., Almeida, Quincy J., Inbal, Maidan, Thaler, Avner, Shirvan, Julia, Cedarbaum, Jesse M., Giladi, Nir, Hausdorff, Jeffrey M.

“…ABSTRACT Background It is not clear how specific gait measures reflect disease severity across the disease spectrum in Parkinson's disease (PD). Objective To…”
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Arm swing as a potential new prodromal marker of Parkinson's disease by Mirelman, Anat, Bernad-Elazari, Hagar, Thaler, Avner, Giladi-Yacobi, Eytan, Gurevich, Tanya, Gana-Weisz, Mali, Saunders-Pullman, Rachel, Raymond, Deborah, Doan, Nancy, Bressman, Susan B., Marder, Karen S., Alcalay, Roy N., Rao, Ashwini K., Berg, Daniela, Brockmann, Kathrin, Aasly, Jan, Waro, Bjørg Johanne, Tolosa, Eduardo, Vilas, Dolores, Pont-Sunyer, Claustre, Orr-Urtreger, Avi, Hausdorff, Jeffrey M., Giladi, Nir

“…ABSTRACT Background Reduced arm swing is a well‐known clinical feature of Parkinson's disease (PD), often observed early in the course of the disease. We…”
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Whole brain and deep gray matter structure segmentation: Quantitative comparison between MPRAGE and MP2RAGE sequences by Droby, Amgad, Thaler, Avner, Giladi, Nir, Hutchison, R. Matthew, Mirelman, Anat, Ben Bashat, Dafna, Artzi, Moran

“…Objective T1-weighted MRI images are commonly used for volumetric assessment of brain structures. Magnetization prepared 2 rapid gradient echo (MP2RAGE)…”
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Effects of aging on arm swing during gait: The role of gait speed and dual tasking by Mirelman, Anat, O], [A.

“…Healthy walking is characterized by pronounced arm swing and axial rotation. Aging effects on gait speed, stride length and stride time variability have been…”
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Tossing and Turning in Bed: Nocturnal Movements in Parkinson's Disease by Mirelman, Anat, Hillel, Inbar, Rochester, Lynn, Del Din, Silvia, Bloem, Bastiaan R., Avanzino, Laura, Nieuwboer, Alice, Maidan, Inbal, Herman, Talia, Thaler, Avner, Gurevich, Tanya, Kestenbaum, Meir, Orr‐Urtreger, Avi, Brys, Mirek, Cedarbaum, Jesse M., Giladi, Nir, Hausdorff, Jeffrey M.

“…ABSTRACT Background Sleep disturbances and nocturnal hypokinesia are common in Parkinson's disease (PD). Recent work using wearable technologies showed fewer…”
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Imaging Markers in Genetic Forms of Parkinson’s Disease by Droby, Amgad, Thaler, Avner, Mirelman, Anat

“…Parkinson’s disease (PD) is a complex neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and resting tremor. While the…”
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Metabolic syndrome does not influence the phenotype of LRRK2 and GBA related Parkinson’s disease by Thaler, Avner, Shenhar-Tsarfaty, Shani, Shaked, Yanay, Gurevich, Tanya, Omer, Nurit, Bar-Shira, Anat, Gana-Weisz, Mali, Goldstein, Orly, Kestenbaum, Meir, Cedarbaum, Jesse M., Orr-Urtreger, Avi, Giladi, Nir, Mirelman, Anat

“…In order toevaluate the influence of the metabolic syndrome (MS) (obesity, hypertension, elevated triglycerides, reduced levels of HDL cholesterol and glucose…”
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Perspective on the current state of the LRRK2 field by Taymans, Jean-Marc, Fell, Matt, Greenamyre, Tim, Hirst, Warren D., Mamais, Adamantios, Padmanabhan, Shalini, Peter, Inga, Rideout, Hardy, Thaler, Avner

“…Almost 2 decades after linking LRRK2 to Parkinson’s disease, a vibrant research field has developed around the study of this gene and its protein product…”
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Biochemical markers for severity and risk in GBA and LRRK2 Parkinson’s disease by Thaler, Avner, Omer, Nurit, Giladi, Nir, Gurevich, Tanya, Bar-Shira, Anat, Gana-Weisz, Mali, Goldstein, Orly, Kestenbaum, Meir, Cedarbaum, Jesse M., Orr-Urtreger, Avi, Shenhar-Tsarfaty, Shani, Mirelman, Anat

“…Background The phenotype of Parkinson’s disease (PD) is variable with mutations in genes such as LRRK2 and GBA explaining part of this heterogeneity…”
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DaT-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers by Artzi, Moran, Even-Sapir, Einat, Lerman Shacham, Hedva, Thaler, Avner, Urterger, Avi Orr, Bressman, Susan, Marder, Karen, Hendler, Talma, Giladi, Nir, Ben Bashat, Dafna, Mirelman, Anat

“…Identification of early changes in Dopamine-Transporter (DaT) SPECT imaging expected in the prodromal phase of Parkinson's disease (PD), are usually…”
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Correction: The natural history study of preclinical genetic Creutzfeldt-Jakob Disease (CJD): a prospective longitudinal study protocol by Bregman, Noa, Shiner, Tamara, Kavé, Gitit, Alcalay, Roy, Gana-Weisz, Mali, Goldstein, Orly, Glinka, Tal, Aizenstein, Orna, Ben Bashat, Dafna, Alcalay, Yifat, Mirelman, Anat, Thaler, Avner, Giladi, Nir, Omer, Nurit

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The GBA-370Rec Parkinson's disease risk haplotype harbors a potentially pathogenic variant in the mitochondrial gene SLC25A44 by Goldstein, Orly, Gana-Weisz, Mali, Attar, Reut, Bar-Shira, Anat, Lederkremer, Martine, Shiner, Tamara, Thaler, Avner, Mirelman, Anat, Giladi, Nir, Orr-Urtreger, Avi

“…GBA variations are common risk factors for Parkinson's disease (PD), and are found in 21.7% of Ashkenazi PD patients (AJ-PD), 4.23% of them carry an allele,…”
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TMS-evoked potentials unveil occipital network involvement in patients diagnosed with Parkinson’s disease within 5 years of inclusion by Zifman, Noa, Levy-Lamdan, Ofri, Hiller, Tal, Thaler, Avner, Dolev, Iftach, Mirelman, Anat, Fogel, Hilla, Hallett, Mark, Maidan, Inbal

“…Distinguishing Parkinson’s disease (PD) subgroups may be achieved by observing network responses to external stimuli. We compared TMS-evoked potential (TEP)…”
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A novel super-resolution microscopy platform for cutaneous alpha-synuclein detection in Parkinson's disease by Sade, Ofir, Fischel, Daphna, Barak-Broner, Noa, Halevi, Shir, Gottfried, Irit, Bar-On, Dana, Sachs, Stefan, Mirelman, Anat, Thaler, Avner, Gour, Aviv, Kestenbaum, Meir, Gana Weisz, Mali, Anis, Saar, Soto, Claudio, Roitman, Melanie Shanie, Shahar, Shimon, Doppler, Kathrin, Sauer, Markus, Giladi, Nir, Lev, Nirit, Alcalay, Roy N, Hassin-Baer, Sharon, Ashery, Uri

“…Alpha-synuclein (aSyn) aggregates in the central nervous system are the main pathological hallmark of Parkinson's disease (PD). ASyn aggregates have also been…”
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Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers by Droby, Amgad, Artzi, Moran, Lerman, Hedva, Hutchison, R. Matthew, Bashat, Dafna Ben, Omer, Nurit, Gurevich, Tanya, Orr-Urtreger, Avi, Cohen, Batsheva, Cedarbaum, Jesse M., Sapir, Einat Even, Giladi, Nir, Mirelman, Anat, Thaler, Avner

“…Non-manifesting carriers (NMCs) of Parkinson’s disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine…”
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Fall risk and gait in Parkinson's disease: The role of the LRRK2 G2019S mutation by Mirelman, Anat, Heman, Talia, Yasinovsky, Kira, Thaler, Avner, Gurevich, Tanya, Marder, Karen, Bressman, Susan, Bar-Shira, Anat, Orr-Urtreger, Avi, Giladi, Nir, Hausdorff, Jeffrey M.

“…ABSTRACT Patients with Parkinson's disease (PD) who carry the G2019S mutation (a glycine to serine substitution at amino acid 2019) in the leucine‐rich repeat…”
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Hierarchical Data-Driven Analysis of Clinical Symptoms Among Patients With Parkinson's Disease by Kozlovski, Tal, Mitelpunkt, Alexis, Thaler, Avner, Gurevich, Tanya, Orr-Urtreger, Avi, Gana-Weisz, Mali, Shachar, Netta, Galili, Tal, Marcus-Kalish, Mira, Bressman, Susan, Marder, Karen, Giladi, Nir, Benjamini, Yoav, Mirelman, Anat

“…Mutations in the LRRK2 and GBA genes are the most common inherited causes of Parkinson's disease (PD). Studies exploring phenotypic differences based on…”
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Neuromelanin and T2-MRI for the assessment of genetically at-risk, prodromal, and symptomatic Parkinson’s disease by Ben Bashat, Dafna, Thaler, Avner, Lerman Shacham, Hedva, Even-Sapir, Einat, Hutchison, Matthew, Evans, Karleyton C., Orr-Urterger, Avi, Cedarbaum, Jesse M., Droby, Amgad, Giladi, Nir, Mirelman, Anat, Artzi, Moran

“…MRI was suggested as a promising method for the diagnosis and assessment of Parkinson’s Disease (PD). We aimed to assess the sensitivity of neuromelanin-MRI…”
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