Search Results - "Thalalla Gamage, Supuni"

Quantitative nucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq by Thalalla Gamage, Supuni, Sas-Chen, Aldema, Schwartz, Schraga, Meier, Jordan L.

“…A prerequisite to defining the transcriptome-wide functions of RNA modifications is the ability to accurately determine their location. Here, we present…”
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Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution by Bortolin-Cavaillé, Marie-Line, Quillien, Aurélie, Thalalla Gamage, Supuni, Thomas, Justin M, Sas-Chen, Aldema, Sharma, Sunny, Plisson-Chastang, Célia, Vandel, Laurence, Blader, Patrick, Lafontaine, Denis L J, Schwartz, Schraga, Meier, Jordan L, Cavaillé, Jérôme

“…NAT10 is an essential enzyme that catalyzes N4-acetylcytidine (ac4C) in eukaryotic transfer RNA and 18S ribosomal RNA. Recent studies suggested that rRNA…”
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Activity-based profiling in RNA by Thalalla Gamage, Supuni, Meier, Jordan L.

“…RNA modifications are emerging regulators of development and disease. A metabolic labeling approach using 5-fluorocytidine (5-FCyd) allows the mechanism-based…”
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Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping by Sas-Chen, Aldema, Thomas, Justin M., Matzov, Donna, Taoka, Masato, Nance, Kellie D., Nir, Ronit, Bryson, Keri M., Shachar, Ran, Liman, Geraldy L. S., Burkhart, Brett W., Gamage, Supuni Thalalla, Nobe, Yuko, Briney, Chloe A., Levy, Michaella J., Fuchs, Ryan T., Robb, G. Brett, Hartmann, Jesse, Sharma, Sunny, Lin, Qishan, Florens, Laurence, Washburn, Michael P., Isobe, Toshiaki, Santangelo, Thomas J., Shalev-Benami, Moran, Meier, Jordan L., Schwartz, Schraga

“…N 4 -acetylcytidine (ac 4 C) is an ancient and highly conserved RNA modification that is present on tRNA and rRNA and has recently been investigated in…”
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Antisense pairing and SNORD13 structure guide RNA cytidine acetylation by Thalalla Gamage, Supuni, Bortolin-Cavaillé, Marie-Line, Link, Courtney, Bryson, Keri, Sas-Chen, Aldema, Schwartz, Schraga, Cavaillé, Jérôme, Meier, Jordan L

“…N4-acetylcytidine (ac C) is an RNA nucleobase found in all domains of life. The establishment of ac C in helix 45 (h45) of human 18S ribosomal RNA (rRNA)…”
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Cytidine Acetylation Across the Tree of Life by Thalalla Gamage, Supuni, Howpay Manage, Shereen A., Chu, T. Thu, Meier, Jordan L.

“…Conspectus Acetylation plays a critical role in regulating eukaryotic transcription via the modification of histones. Beyond this well-documented function, a…”
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Protonation-Dependent Sequencing of 5‑Formylcytidine in RNA by Link, Courtney N, Thalalla Gamage, Supuni, Gallimore, Diamond, Kopajtich, Robert, Evans, Christine, Nance, Samantha, Fox, Stephen D, Andresson, Thorkell, Chari, Raj, Ivanic, Joseph, Prokisch, Holger, Meier, Jordan L

“…Chemical modification of cytidine in noncoding RNAs plays a key role in regulating translation and disease. However, the distribution and dynamics of many of…”
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Conditional Covalent Lethality Driven by Oncometabolite Accumulation by Perez, Minervo, Nance, Kellie D., Bak, Daniel W., Thalalla Gamage, Supuni, Najera, Susana S., Conte, Amy N., Linehan, W. Marston, Weerapana, Eranthie, Meier, Jordan L.

“…Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase…”
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Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma by Fitzsimmons, Christina M, Mandler, Mariana D, Lunger, Judith C, Chan, Dalen, Maligireddy, Siddhardha S, Schmiechen, Alexandra C, Gamage, Supuni Thalalla, Link, Courtney, Jenkins, Lisa M, Chan, King, Andresson, Thorkell, Crooks, Daniel R, Meier, Jordan L, Linehan, W Marston, Batista, Pedro J

“…Metabolic reprogramming is a hallmark of cancer that facilitates changes in many adaptive biological processes. Mutations in the tricarboxylic acid cycle…”
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Cytidine acetylation yields a hypoinflammatory synthetic messenger RNA by Nance, Kellie D, Gamage, Supuni Thalalla, Alam, Md Masud, Yang, Acong, Levy, Michaella J, Link, Courtney N, Florens, Laurence, Washburn, Michael P, Gu, Shuo, Oppenheim, Joost J, Meier, Jordan L

“…Synthetic messenger RNA (mRNA) is an emerging therapeutic platform with important applications in oncology and infectious disease. Effective mRNA medicines…”
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Protonation‐Dependent Sequencing of 5‐Formylcytidine in RNA by Link, Courtney N., Thalalla Gamage, Supuni, Gallimore, Diamond A., Kopajtich, Robert, Evans, Christine N., Nance, Samantha R., Fox, Stephen D., Andresson, Thorkell, Chari, Raj, Ivanic, Joseph, Prokisch, Holger, Meier, Jordan L.

“…Chemical modification of cytidine in non‐coding RNAs plays a key role in regulating translation and disease. However, the distribution and dynamics of many of…”
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Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation by Shrimp, Jonathan H, Jing, Yihang, Gamage, Supuni Thalalla, Nelson, Kathryn M, Han, Joseph, Bryson, Keri M, Montgomery, David C, Thomas, Justin M, Nance, Kellie D, Sharma, Sunny, Fox, Stephen D, Andressen, Thorkell, Sinclair, Wilson R, Wu, Hong, Allali-Hassani, Abdellah, Senisterra, Guillermo, Vedadi, Masoud, Lafontaine, Denis, Dahlin, Jayme L, Marmorstein, Ronen, Walters, Michael A, Meier, Jordan L

“…Remodelin is a putative small molecule inhibitor of the RNA acetyltransferase NAT10 which has shown preclinical efficacy in models of the premature aging…”
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Insights into Nucleic Acid-Platinum(II) Compound Interactions and Structural Impacts by Thalalla Gamage, Supuni

“…With the discovery of cisplatin in the 1960s, it has been widely studied as a precursor for anticancer drug development. Despite its effectiveness against…”
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Carbohydrate‐linked cisplatin analogue: reactivity studies with RNA and DNA by Gamage, Supuni Duneeshya Thalalla, Muthunayake, Nisansala, Sonousi, Amr, Crich, David, Chow, Christine

“…Abstract only With the discovery of cisplatin in the 1960s, it has been widely studied as a precursor for anticancer drug development. Despite its…”
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