Search Results - "Thakur, Poonam"

Inhibition of Neuroinflammation and Mitochondrial Dysfunctions by Carbenoxolone in the Rotenone Model of Parkinson’s Disease by Thakur, Poonam, Nehru, Bimla

“…α-Synuclein aggregation contributes to the Parkinson’s disease (PD) pathology in multiple ways—the two most important being the activation of neuroinflammation…”
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Long-term heat shock proteins (HSPs) induction by carbenoxolone improves hallmark features of Parkinson's disease in a rotenone-based model by Thakur, Poonam, Nehru, Bimla

“…Protein aggregation and dysfunction of ubiquitin proteasome system (UPS) have been implicated in Parkinson's disease (PD) pathology for a long time. Heat shock…”
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Permeability Behavior of Nanocrystalline Solid Dispersion of Dipyridamole Generated Using NanoCrySP Technology by Girdhar, Ashish, Thakur, Poonam Singh, Sheokand, Sneha, Bansal, Arvind K

“…Nanocrystals research has been an area of significant interest lately, providing oral bioavailability benefits to solubility- and/or dissolution rate-limited…”
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Understanding the Oral Absorption of Irbesartan Using Biorelevant Dissolution Testing and PBPK Modeling by Kaur, Navpreet, Thakur, Poonam Singh, Shete, Ganesh, Gangwal, Rahul, Sangamwar, Abhay T., Bansal, Arvind Kumar

“…Poorly soluble weak bases form a significant proportion of the drugs available in the market thereby making it imperative to understand their absorption…”
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Inclusive Workplaces: Lessons from Theory and Practice by Vohra, Neharika, Chari (Coordinators), Vijayalakshmi, Mathur, Putul, Sudarshan, Priyanka, Verma, Nisha, Mathur, Nihar, Thakur, Poonam, Chopra, Tarika, Srivastava, Yuvaraj, Gupta, Shikha, Dasmahapatra, Vir, Fonia, Sharda, Gandhi, Harish K

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The accuracy of polyuria, polydipsia, polyphagia, and Indian Diabetes Risk Score in adults screened for diabetes mellitus type-II by Shivshakti D Pawar, Poonam Thakur, B K Radhe, Harshal Jadhav, Vivek Behere, Vikrant Pagar

“…Context: The World Health Organization report suggests that over 19% of the world's diabetic population currently resides in India. Unfortunately, >50% of the…”
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Are ion channels potential therapeutic targets for Parkinson’s disease? by Daniel, Neha Hanna, Aravind, Ananya, Thakur, Poonam

“…•Release of dopamine by nigral neurons is regulated by several ion channels.•Many classes of ion channels become dysfunctional during PD.•Ion-channels may…”
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Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson’s disease pathology by Thakur, Poonam, Nehru, Bimla

“…•Effect of sodium salicylate (SS) in rotenone induced proteotoxic stress was checked.•SS induced HSF-1, HSP-40 and HSP-27 expression but not HSP-70 and…”
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Volumetric and acoustic methods for investigating molecular interactions of antibiotic drug doxycycline hyclate in water and in aqueous solution of sodium chloride and potassium chloride at different temperatures (293.15–313.15) K by Lomesh, Shashi Kant, Nathan, Vikas, Bala, Madhu, Thakur, Poonam

“…The solution properties of antibiotic drug Doxycycline Hyclate (DH) were investigated to explore molecular interactions with aqueous NaCl and KCl solutions…”
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Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain by Thakur, Poonam, Breger, Ludivine S., Lundblad, Martin, Wan, Oi Wan, Mattsson, Bengt, Luk, Kelvin C., Lee, Virginia M. Y., Trojanowski, John Q., Björklund, Anders

“…Although a causative role of α-synuclein (α-syn) is well established in Parkinson’s disease pathogenesis, available animal models of synucleinopathy do not…”
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α-Synuclein 2.0 — Moving towards Cell Type Specific Pathophysiology by Thakur, Poonam, Chiu, Wei Hua, Roeper, Jochen, Goldberg, Joshua A.

“…Since the landmark discovery that point mutations in the α-synuclein gene (SNCA) cause familial Parkinson's disease (PD) more than 2 decades ago, extensive…”
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Factors Affecting Crystallization Kinetics of Fenofibrate and Its Implications for the Generation of Nanocrystalline Solid Dispersions via Spray Drying by Thakur, Poonam Singh, Sheokand, Sneha, Bansal, Arvind K

“…The present study investigates the role of formulation and process parameters on solution- and solid-state crystallization kinetics of fenofibrate (FNT) to…”
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Interaction of alpha-synuclein with lipids by Kachappilly, Neha, Srivastava, Jyotirmay, Swain, Bani Prasad, Thakur, Poonam

“…Alpha-synuclein (α-syn) is a natively unfolded protein that is abundantly expressed in the central nervous system. Although it has been shown to be involved in…”
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Impact of differential particle size of fenofibrate nanosuspensions on biopharmaceutical performance using physiologically based absorption modeling in rats by Jain, Divisha, Thakur, Poonam Singh, Thakore, Samarth D., Samal, Sanjaya K., Bansal, Arvind K.

“…Particle size and its distribution governs oral biopharmaceutical performance of poorly water-soluble active pharmaceutical ingredients (APIs). Fenofibrate, a…”
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Assessment of Biopharmaceutical Performance of Supersaturating Formulations of Carbamazepine in Rats Using Physiologically Based Pharmacokinetic Modeling by Thakore, Samarth D., Thakur, Poonam Singh, Shete, Ganesh, Gangwal, Rahul, Narang, Ajit S., Sangamwar, Abhay T., Bansal, Arvind Kumar

“…There is an overgrowing emphasis on supersaturating drug delivery systems (SDDS) with increase in number of poorly water-soluble compounds. However,…”
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Investigation of Need of Natural Bioenhancer for a Metabolism Susceptible Drug—Raloxifene, in a Designed Self-Emulsifying Drug Delivery System by Thakur, Poonam Singh, Singh, Narinder, Sangamwar, Abhay T., Bansal, Arvind Kumar

“…Bioenhancers can increase the bioavailability of metabolism susceptible drugs. The present study was designed to understand the impact of bioenhancer on…”
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Impact of differential surface anisotropy on biopharmaceutical performance of celecoxib by Thakur, Poonam Singh, Modi, Sameer Ramanlal, Calvin Sun, Changquan, Bansal, Arvind K.

“…Abstract only…”
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Modeling Parkinson's disease pathology by combination of fibril seeds and a-synuclein overexpression in the rat brain by Thakur, Poonam, Breger, Ludivine S, Lundblad, Martin, Wan, Oi Wan, Mattsson, Bengt, Luk, Kelvin C, Y Lee, Virginia M, Trojanowski, John Q, Björklund, Anders

“…Although a causative role of α-synuclein (α-syn) is well established in Parkinson's disease pathogenesis, available animal models of synucleinopathy do not…”
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Use of Cord Blood Albumin and Cord Blood Bilirubin in Early Detection of Neonatal Hyperbilirubinemia by Thakur, Poonam

“…IntroductionDischarging healthy term babies from the hospitals after delivery at the increasingly earlier postnatal ages has recently become a common practice…”
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Routing Protocols in MANET: An Overview by Kaur, Gunseerat, Thakur, Poonam

“…Mobile Ad-hoc Networks also known as MANETs belong to a collaborative collection of different mobile devices from a heterogeneous network, the prolific feature…”
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