Search Results - "Thakker, Nalin"

Therapeutic targeting of cathepsin C: from pathophysiology to treatment by Korkmaz, Brice, Caughey, George H., Chapple, Iain, Gauthier, Francis, Hirschfeld, Josefine, Jenne, Dieter E., Kettritz, Ralph, Lalmanach, Gilles, Lamort, Anne-Sophie, Lauritzen, Conni, Łȩgowska, Monika, Lesner, Adam, Marchand-Adam, Sylvain, McKaig, Sarah J., Moss, Celia, Pedersen, John, Roberts, Helen, Schreiber, Adrian, Seren, Seda, Thakker, Nalin S.

“…Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the…”
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Characterization of neutrophil function in Papillon‐Lefèvre syndrome by Roberts, Helen, White, Phillipa, Dias, Irundika, McKaig, Sarah, Veeramachaneni, Ratna, Thakker, Nalin, Grant, Melissa, Chapple, Iain

“…Neutrophils from PLS patients exhibit functional abnormalities possibly explaining pre‐pubertal periodontitis, in their disease. Papillon‐Lefévre syndrome is a…”
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Loss of epithelial markers is an early event in oral dysplasia and is observed within the safety margin of dysplastic and T1 OSCC biopsies by Abdalla, Zahra, Walsh, Tanya, Thakker, Nalin, Ward, Christopher M

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer that is associated with poor 5-year patient survival. Disease treatment is further compounded…”
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Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study by ANANTHARAMAN, Devasena, GHEIT, Tarik, HOLCATOVA, Ivana, MERLETTI, Franco, KJAERHEIM, Kristina, TALAMINI, Renato, SIMONATO, Lorenzo, CASTELLSAGUE, Xavier, MACFARLANE, Tatiana V, BIGGS, Anne-Marie, THAKKER, Nalin, ZNAOR, Ariana, WATERBOER, Tim, THOMSON, Peter, CANOVA, Cristina, CONWAY, David I, HEALY, Claire M, TOMMASINO, Massimo, PAWLITA, Michael, BRENNAN, Paul, ABEDI-ARDEKANI, Behnoush, CARREIRA, Christine, MCKAY-CHOPIN, Sandrine, GABORIEAU, Valerie, MARRON, Manuela, LAGIOU, Pagona, AHRENS, Wolfgang

“…Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT). Associations between type-specific HPV…”
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Evaluation of a new binary system of grading oral epithelial dysplasia for prediction of malignant transformation by Kujan, Omar, Oliver, Richard J., Khattab, Ammar, Roberts, Stephen A., Thakker, Nalin, Sloan, Philip

“…The aim of this paper is to assess the reproducibility of a novel binary grading system (high/low risk) of oral epithelial dysplasia and to compare it with the…”
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Why oral histopathology suffers inter-observer variability on grading oral epithelial dysplasia: An attempt to understand the sources of variation by Kujan, Omar, Khattab, Ammar, Oliver, Richard J, Roberts, Stephen A, Thakker, Nalin, Sloan, Philip

“…Summary The present study attempted to assess the reasons behind the inter-observer variation in grading oral epithelial dysplasia (OED). Three oral…”
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Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis by Pastorino, Roberta, Puggina, Anna, Carreras-Torres, Robert, Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V., Barzan, Luigi, Canova, Cristina, Thakker, Nalin S., Conway, David I., Znaor, Ariana, Healy, Claire M., Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Brennan, Paul, Gaborieau, Valérie, McKay, James D., Boccia, Stefania

“…With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association…”
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Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis by James, Jacqueline, Davies, Robin, Read, Andrew P, Roberts, Emma, Woods, C. Geoffrey, Wood, A. Joseph, McCormick, Derek, Hewitt, Chelsee, Ghaffar, Khaled Abdul, Thakker, Nalin S, Widmer, Richard, Wong, Melanie, Sloan, Philip, Lench, Nicholas, Hussein, Ibtessam Ramzy, Pemberton, Michael, Dixon, Michael J, Markham, Alexander, Temtamy, Samia A, Wu, Chu Lee, Toomes, Carmel, Moynihan, Leanne

“…Papillon-Lefèvre syndrome, or keratosis palmoplantaris with periodontopathia (PLS, MIM 245000), is an autosomal recessive disorder that is mainly ascertained…”
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Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method by Johansson, Mattias, Roberts, Angus, Chen, Dan, Li, Yaoyong, Delahaye-Sourdeix, Manon, Aswani, Niraj, Greenwood, Mark A, Benhamou, Simone, Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Thakker, Nalin S, Conway, David I, Znaor, Ariana, Healy, Claire M, Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabiánová, Eleonóra, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, Jose, Boffetta, Paolo, Franceschi, Silvia, Herrero, Rolando, Fernandez Garrote, Leticia, Talamini, Renato, Boccia, Stefania, Galan, Pilar, Vatten, Lars, Thomson, Peter, Zelenika, Diana, Lathrop, Mark, Byrnes, Graham, Cunningham, Hamish, Brennan, Paul, Wakefield, Jon, McKay, James D

“…Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by…”
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Evaluation of Screening Strategies for Improving Oral Cancer Mortality: A Cochrane Systematic Review by Kujan, Omar, Glenny, Anne‐Marie, Duxbury, John, Thakker, Nalin, Sloan, Philip

“…Worldwide, oral cancer has one of the lowest survival rates. It is well recognized that survival rates are improved if the disease is treated in its early…”
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Fragile Histidine Triad Expression in Oral Squamous Cell Carcinoma and Precursor Lesions by KUJAN, Omar, OLIVER, Richard, ROZ, Luca, SOZZI, Gabriella, RIBEIRO, Noel, WOODWARDS, Robert, THAKKER, Nalin, SLOAN, Philip

“…Pupose: Fragile histidine triad (FHIT) expression in precursor oral lesions (POL) and oral squamous cell carcinomas (OSCC) was studied with regard to ( a ) the…”
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The role of cathepsin C in Papillon-Lefèvre syndrome, prepubertal periodontitis, and aggressive periodontitis by Hewitt, Chelsee, McCormick, Derek, Linden, Gerry, Turk, Dusan, Stern, Igor, Wallace, Ian, Southern, Louise, Zhang, Liqun, Howard, Rebecca, Bullon, Pedro, Wong, Melanie, Widmer, Richard, Gaffar, Khaled Abdul, Awawdeh, Lama, Briggs, Jim, Yaghmai, Reza, Jabs, Ethlin W., Hoeger, Peter, Bleck, Oliver, Rüdiger, Stefan G., Petersilka, Gregor, Battino, Maurizio, Brett, Peter, Hattab, Faiez, Al-Hamed, Mohamed, Sloan, Philip, Toomes, Carmel, Dixon, Mike, James, Jacqueline, Read, Andrew P., Thakker, Nalin

“…We have previously reported that loss‐of‐function mutations in the cathepsin C gene (CTSC) result in Papillon‐Lefèvre syndrome, an autosomal recessive…”
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Tumor Epression of Major Vault Protein is an Adverse Prognostic Factor for Radiotherapy Outcome in Oropharyngeal Carcinoma by Silva, Priyamal, M.R.C.S, West, Catharine M., Ph.D, Slevin, Nick, F.R.C.R, Valentine, Helen, M.RSc, Ryder, W. David J., Grad. I.S, Hampson, Lynne, Ph.D, Bibi, Rufzan, Ph.D, Sloan, Philip, Ph.D, Thakker, Nalin, Ph.D, Homer, Jarrod, F.R.C.S, Hampson, Ian, Ph.D

“…Purpose: Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport, with the major vault protein (MVP or lung resistance-related…”
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Mutation analysis of the cathepsin C gene in Indian families with Papillon-Lefèvre syndrome by Selvaraju, Veeriah, Markandaya, Manjunath, Prasad, Pullabatla Venkata Siva, Sathyan, Parthasarathy, Sethuraman, Gomathy, Srivastava, Satish Chandra, Thakker, Nalin, Kumar, Arun

“…PLS is a rare autosomal recessive disorder characterized by early onset periodontopathia and palmar plantar keratosis. PLS is caused by mutations in the…”
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The presence of multiple regions of homozygous deletion at the CSMD1 locus in oral squamous cell carcinoma question the role of CSMD1 in head and neck carcinogenesis by Toomes, Carmel, Jackson, Andrew, Maguire, Kristie, Wood, Joseph, Gollin, Susanne, Ishwad, Chandramohan, Paterson, Ian, Prime, Steven, Parkinson, Kenneth, Bell, Sandra, Woods, Geoffrey, Markham, Alexander, Oliver, Richard, Woodward, Robert, Sloan, Philip, Dixon, Michael, Read, Andrew, Thakker, Nalin

“…We and others previously identified a region of hemizygous or homozygous deletion at chromosome band 8p23 in oral and oropharyngeal squamous cell carcinomas…”
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Tumours of the oral cavity by Thakker, Nalin, Hunter, Keith

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Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy by Veeramachaneni, Ratna, Walker, Thomas, Revil, Timothée, Weck, Antoine De, Badescu, Dunarel, O’Sullivan, James, Higgins, Catherine, Elliott, Louise, Liloglou, Triantafillos, Risk, Janet M., Shaw, Richard, Hampson, Lynne, Hampson, Ian, Dearden, Simon, Woodwards, Robert, Prime, Stephen, Hunter, Keith, Parkinson, Eric Kenneth, Ragoussis, Jiannis, Thakker, Nalin

“…We report changes in the genomic landscape in the development of head and neck squamous cell carcinomas HNSCC from potentially premalignant lesions (PPOLS) to…”
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An overview of the molecular pathology of head and neck cancer, and its clinical implications by Hunter, Keith, Parkinson, Eric Kenneth, Thakker, Nalin

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Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma by Kamal, Mohamed, Shaaban, Abeer M, Zhang, Liqun, Walker, Clare, Gray, Sally, Thakker, Nalin, Toomes, Carmel, Speirs, Valerie, Bell, Sandra M

“…CUB and SUSHI multiple domain protein 1 (CSMD1) is a candidate tumour suppressor gene that maps to chromosome 8p23, a region deleted in many tumour types…”
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A molecular analysis of individuals with neurofibromatosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genotype-phenotype correlations by Sharif, Saba, Upadhyaya, Meena, Ferner, Rosalie, Majounie, Elisa, Shenton, Andrew, Baser, Michael, Thakker, Nalin, Evans, D Gareth

“…Neurofibromatosis type 1 (NF1) affects 1 in 2500 people, and 15% of these may develop an optic pathway glioma (OPG). OPGs behave differently in NF1, and, given…”
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