Search Results - "Thakkar, Mahesh M"

Lesion of the basal forebrain cholinergic neurons attenuates sleepiness and adenosine after alcohol consumption by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…Alcohol has a profound effect on sleep. However, neuronal substrates mediating sleep‐promoting effects of alcohol are unknown. Since the basal forebrain (BF)…”
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Adenosine and Glutamate Signaling in Neuron-Glial Interactions: Implications in Alcoholism and Sleep Disorders by Nam, Hyung W., McIver, Sally R., Hinton, David J., Thakkar, Mahesh M., Sari, Youssef, Parkinson, Fiona E., Haydon, Phillip G., Choi, Doo-Sup

“…Recent studies have demonstrated that the function of glia is not restricted to the support of neuronal function. Especially, astrocytes are essential for…”
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Ischemic Stroke Disrupts Sleep Homeostasis in Middle-Aged Mice by Sharma, Rishi, Chischolm, Abigail, Parikh, Meet, Qureshi, Adnan I, Sahota, Pradeep, Thakkar, Mahesh M

“…Sleep disturbances, including insomnia and excessive daytime sleepiness, are highly prevalent in patients with ischemic stroke (IS), which severely impacts…”
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Histamine in the regulation of wakefulness by Thakkar, Mahesh M

“…Summary The histaminergic system is exclusively localized within the posterior hypothalamus with projection to almost all the major regions of the central…”
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Alcohol disrupts sleep homeostasis by Thakkar, Mahesh M, Sharma, Rishi, Sahota, Pradeep

“…Abstract Alcohol is a potent somnogen and one of the most commonly used “over the counter” sleep aids. In healthy non-alcoholics, acute alcohol decreases sleep…”
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Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…Melatonin promotes sleep. However, the underlying mechanisms are unknown. Orexin neurons in the perifornical lateral hypothalamus (PFH) are pivotal for wake…”
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Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice by Brown, Ritchie E., McKenna, James T., Winston, Stuart, Basheer, Radhika, Yanagawa, Yuchio, Thakkar, Mahesh M., McCarley, Robert W.

“…Recent experiments suggest that brainstem GABAergic neurons may control rapid‐eye‐movement (REM) sleep. However, understanding their pharmacology/physiology…”
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REM sleep changes in rats induced by siRNA-mediated orexin knockdown by Chen, Lichao, Thakkar, Mahesh M., Winston, Stuart, Bolortuya, Yunren, Basheer, Radhika, McCarley, Robert W.

“…Short interfering RNAs (siRNA) targeting prepro‐orexin mRNA were microinjected into the rat perifornical hypothalamus. Prepro‐orexin siRNA‐treated rats had a…”
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Chronic alcohol exposure reduces acetylated histones in the sleep-wake regulatory brain regions to cause insomnia during withdrawal by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…Alcohol use disorder (AUD) develops after chronic and heavy use of alcohol. Insomnia, a hallmark of AUD, plays a crucial role in the development of AUD…”
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A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis, and down‐regulates equilibrative nucleoside transporter 1 by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…Binge alcohol drinking, a risky pattern of alcohol consumption, has severe consequences toward health and well‐being of an individual, his family, and society…”
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Rats exposed to chronic alcohol display protracted insomnia and daytime sleepiness-like behavior during alcohol withdrawal by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…During withdrawal, alcohol dependent rats:.•displayed protracted sleep disturbances.•showed insomnia-like symptoms during light (inactive) period.•showed a…”
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Severe and protracted sleep disruptions in mouse model of post-traumatic stress disorder by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M

“…Abstract Increasing evidences suggest that the predator threat model is a valid animal model of post-traumatic stress disorder (PTSD). However, sleep has never…”
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Sleep Loss Immediately After Fear Memory Reactivation Attenuates Fear Memory Reconsolidation by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…•Permanently stored memories become labile through a process of reactivation.•Reactivated memories need reconsolidation to become permanent.•Sleep deprivation,…”
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Short-term sleep deprivation immediately after contextual conditioning inhibits BDNF signaling and disrupts memory consolidation in predator odor trauma mice model of PTSD by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…•Mice displayed sleep disturbances after contextual conditioning using predator odor trauma (POT).•Short-term sleep deprivation (SD; 3 h) immediately after POT…”
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Role of adenosine and the orexinergic perifornical hypothalamus in sleep-promoting effects of ethanol by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M

“…Strong clinical and preclinical evidence suggests that acute ethanol promotes sleep. However, very little is known about how and where ethanol acts to promote…”
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Adenosinergic modulation of basal forebrain and preoptic/anterior hypothalamic neuronal activity in the control of behavioral state by Strecker, Robert E, Morairty, Stephen, Thakkar, Mahesh M, Porkka-Heiskanen, Tarja, Basheer, Radhika, Dauphin, Lynda J, Rainnie, Donald G, Portas, Chiara M, Greene, Robert W, McCarley, Robert W

“…This review describes a series of animal experiments that investigate the role of endogenous adenosine (AD) in sleep. We propose that AD is a modulator of the…”
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Orexin gene expression is downregulated in alcohol dependent rats during acute alcohol withdrawal by Sharma, Rishi, Sharma, Abhilasha, Sahota, Pradeep, Thakkar, Mahesh M.

“…•Alcohol withdrawal symptoms are life-threatening and a major cause of relapse.•Daytime sleepiness is one of the severe alcohol withdrawal symptoms.•Orexin is…”
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Behavioral State Control through Differential Serotonergic Inhibition in the Mesopontine Cholinergic Nuclei: A Simultaneous Unit Recording and Microdialysis Study by Thakkar, Mahesh M, Strecker, Robert E, McCarley, Robert W

“…Cholinergic neurons of the mesopontine nuclei are strongly implicated in behavioral state regulation. One population of neurons in the cholinergic zone of the…”
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Nicotine Administration in the Cholinergic Basal Forebrain Increases Alcohol Consumption in C57BL/6J Mice by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M.

“…Background Alcohol and nicotine are the most commonly abused drugs. The frequent co‐morbidity of alcohol and nicotine addiction has led to the hypothesis that…”
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Rapid tolerance development to the NREM sleep promoting effect of alcohol by Sharma, Rishi, Sahota, Pradeep, Thakkar, Mahesh M

“…Alcohol tolerance is a major contributor towards the development of alcohol dependence. Does alcohol intake result in rapid tolerance development to alcohol…”
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