Search Results - "Thai, Tran C"

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade by Aref, Amir R, Campisi, Marco, Ivanova, Elena, Portell, Andrew, Larios, Dalia, Piel, Brandon P, Mathur, Natasha, Zhou, Chensheng, Coakley, Raven Vlahos, Bartels, Alan, Bowden, Michaela, Herbert, Zach, Hill, Sarah, Gilhooley, Sean, Carter, Jacob, Cañadas, Israel, Thai, Tran C, Kitajima, Shunsuke, Chiono, Valeria, Paweletz, Cloud P, Barbie, David A, Kamm, Roger D, Jenkins, Russell W

“…Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed, several microdevices are being developed specifically for…”
Get more information

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion by Li, Fengkai, Kitajima, Shunsuke, Kohno, Susumu, Yoshida, Akiyo, Tange, Shoichiro, Sasaki, Soichiro, Okada, Nobuhiro, Nishimoto, Yuuki, Muranaka, Hayato, Nagatani, Naoko, Suzuki, Misa, Masuda, Sayuri, Thai, Tran C, Nishiuchi, Takumi, Tanaka, Tomoaki, Barbie, David A, Mukaida, Naofumi, Takahashi, Chiaki

“…Cancer cell-intrinsic properties caused by oncogenic mutations have been well characterized; however, how specific oncogenes and tumor suppressors impact the…”
Get full text

ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors by Terai, Hideki, Kitajima, Shunsuke, Potter, Danielle S, Matsui, Yusuke, Quiceno, Laura Gutierrez, Chen, Ting, Kim, Tae-Jung, Rusan, Maria, Thai, Tran C, Piccioni, Federica, Donovan, Katherine A, Kwiatkowski, Nicholas, Hinohara, Kunihiko, Wei, Guo, Gray, Nathanael S, Fischer, Eric S, Wong, Kwok-Kin, Shimamura, Teppei, Letai, Anthony, Hammerman, Peter S, Barbie, David A

“…An increasingly recognized component of resistance to tyrosine kinase inhibitors (TKI) involves persistence of a drug-tolerant subpopulation of cancer cells…”
Get full text

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth by Barbie, Thanh U, Alexe, Gabriela, Aref, Amir R, Li, Shunqiang, Zhu, Zehua, Zhang, Xiuli, Imamura, Yu, Thai, Tran C, Huang, Ying, Bowden, Michaela, Herndon, John, Cohoon, Travis J, Fleming, Timothy, Tamayo, Pablo, Mesirov, Jill P, Ogino, Shuji, Wong, Kwok-Kin, Ellis, Matthew J, Hahn, William C, Barbie, David A, Gillanders, William E

“…Triple-negative breast cancers (TNBCs) are a heterogeneous set of cancers that are defined by the absence of hormone receptor expression and HER2…”
Get full text

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer by Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A

“…Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. Efforts to enhance the immunogenicity of EGFR-mutated lung cancer have been…”
Get full text

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS by Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D., Merlino, Ashley A., Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C., Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T., Wong, Kwok-Kin, Barbie, David A.

“…Despite extensive efforts, oncogenic KRAS remains resistant to targeted therapy. Combined downstream RAL-TBK1 and MEK inhibition induces only transient lung…”
Get full text

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit by Zhu, Zehua, Aref, Amir R, Cohoon, Travis J, Barbie, Thanh U, Imamura, Yu, Yang, Shenghong, Moody, Susan E, Shen, Rhine R, Schinzel, Anna C, Thai, Tran C, Reibel, Jacob B, Tamayo, Pablo, Godfrey, Jason T, Qian, Zhi Rong, Page, Asher N, Maciag, Karolina, Chan, Edmond M, Silkworth, Whitney, Labowsky, Mary T, Rozhansky, Lior, Mesirov, Jill P, Gillanders, William E, Ogino, Shuji, Hacohen, Nir, Gaudet, Suzanne, Eck, Michael J, Engelman, Jeffrey A, Corcoran, Ryan B, Wong, Kwok-Kin, Hahn, William C, Barbie, David A

“…Although the roles of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signaling in KRAS-driven tumorigenesis are well established,…”
Get more information

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells by Noyes, Christopher, Kitajima, Shunsuke, Li, Fengkai, Suita, Yusuke, Miriyala, Saradha, Isaac, Shakson, Ahsan, Nagib, Knelson, Erik, Vajdi, Amir, Tani, Tetsuo, Thai, Tran C., Xu, Derek, Murai, Junko, Tapinos, Nikos, Takahashi, Chiaki, Barbie, David A., Yajima, Mamiko

“…Human cancers often re-express germline factors, yet their mechanistic role in oncogenesis and cancer progression remains unknown. Here we demonstrate that…”
Get full text

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer by Kitajima, Shunsuke, Ivanova, Elena, Guo, Sujuan, Yoshida, Ryohei, Campisi, Marco, Sundararaman, Shriram K, Tange, Shoichiro, Mitsuishi, Yoichiro, Thai, Tran C, Masuda, Sayuri, Piel, Brandon P, Sholl, Lynette M, Kirschmeier, Paul T, Paweletz, Cloud P, Watanabe, Hideo, Yajima, Mamiko, Barbie, David A

“…-driven lung cancers frequently inactivate and/or , defining tumor subclasses with emerging clinical relevance. Specifically, - (KL)-mutant lung cancers are…”
Get more information

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids by Jenkins, Russell W, Aref, Amir R, Lizotte, Patrick H, Ivanova, Elena, Stinson, Susanna, Zhou, Chensheng W, Bowden, Michaela, Deng, Jiehui, Liu, Hongye, Miao, Diana, He, Meng Xiao, Walker, William, Zhang, Gao, Tian, Tian, Cheng, Chaoran, Wei, Zhi, Palakurthi, Sangeetha, Bittinger, Mark, Vitzthum, Hans, Kim, Jong Wook, Merlino, Ashley, Quinn, Max, Venkataramani, Chandrasekar, Kaplan, Joshua A, Portell, Andrew, Gokhale, Prafulla C, Phillips, Bart, Smart, Alicia, Rotem, Asaf, Jones, Robert E, Keogh, Lauren, Anguiano, Maria, Stapleton, Lance, Jia, Zhiheng, Barzily-Rokni, Michal, Cañadas, Israel, Thai, Tran C, Hammond, Marc R, Vlahos, Raven, Wang, Eric S, Zhang, Hua, Li, Shuai, Hanna, Glenn J, Huang, Wei, Hoang, Mai P, Piris, Adriano, Eliane, Jean-Pierre, Stemmer-Rachamimov, Anat O, Cameron, Lisa, Su, Mei-Ju, Shah, Parin, Izar, Benjamin, Thakuria, Manisha, LeBoeuf, Nicole R, Rabinowits, Guilherme, Gunda, Viswanath, Parangi, Sareh, Cleary, James M, Miller, Brian C, Kitajima, Shunsuke, Thummalapalli, Rohit, Miao, Benchun, Barbie, Thanh U, Sivathanu, Vivek, Wong, Joshua, Richards, William G, Bueno, Raphael, Yoon, Charles H, Miret, Juan, Herlyn, Meenhard, Garraway, Levi A, Van Allen, Eliezer M, Freeman, Gordon J, Kirschmeier, Paul T, Lorch, Jochen H, Ott, Patrick A, Hodi, F Stephen, Flaherty, Keith T, Kamm, Roger D, Boland, Genevieve M, Wong, Kwok-Kin, Dornan, David, Paweletz, Cloud Peter, Barbie, David A

“…systems that incorporate features of the tumor microenvironment and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in…”
Get more information

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer by Ritter, Jessica L, Zhu, Zehua, Thai, Tran C, Mahadevan, Navin R, Mertins, Philipp, Knelson, Erik H, Piel, Brandon P, Han, Saemi, Jaffe, Jacob D, Carr, Steven A, Barbie, David A, Barbie, Thanh U

“…Triple-negative breast cancer (TNBC) is a heterogeneous disease enriched for mutations in PTEN and dysregulation of innate immune signaling. Here, we…”
Get full text

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer by Kitajima, Shunsuke, Tani, Tetsuo, Springer, Benjamin F., Campisi, Marco, Osaki, Tatsuya, Haratani, Koji, Chen, Minyue, Knelson, Erik H., Mahadevan, Navin R., Ritter, Jessica, Yoshida, Ryohei, Köhler, Jens, Ogino, Atsuko, Nozawa, Ryu-Suke, Sundararaman, Shriram K., Thai, Tran C., Homme, Mizuki, Piel, Brandon, Kivlehan, Sophie, Obua, Bonje N., Purcell, Connor, Yajima, Mamiko, Barbie, Thanh U., Lizotte, Patrick H., Jänne, Pasi A., Paweletz, Cloud P., Gokhale, Prafulla C., Barbie, David A.

“…KRAS-LKB1 (KL) mutant lung cancers silence STING owing to intrinsic mitochondrial dysfunction, resulting in T cell exclusion and resistance to programmed cell…”
Get full text

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity by Mahadevan, Navin R, Knelson, Erik H, Wolff, Jacquelyn O, Vajdi, Amir, Saigí, Maria, Campisi, Marco, Hong, Deli, Thai, Tran C, Piel, Brandon, Han, Saemi, Reinhold, Bruce B, Duke-Cohan, Jonathan S, Poitras, Michael J, Taus, Luke J, Lizotte, Patrick H, Portell, Andrew, Quadros, Victor, Santucci, Alison D, Murayama, Takahiko, Cañadas, Israel, Kitajima, Shunsuke, Akitsu, Aoi, Fridrikh, Maya, Watanabe, Hideo, Reardon, Brendan, Gokhale, Prafulla C, Paweletz, Cloud P, Awad, Mark M, Van Allen, Eliezer M, Lako, Ana, Wang, Xi-Tao, Chen, Benjamin, Hong, Fangxin, Sholl, Lynette M, Tolstorukov, Michael Y, Pfaff, Kathleen, Jänne, Pasi A, Gjini, Evisa, Edwards, Robin, Rodig, Scott, Reinherz, Ellis L, Oser, Matthew G, Barbie, David A

“…Small cell lung carcinoma (SCLC) is highly mutated, yet durable response to immune checkpoint blockade (ICB) is rare. SCLC also exhibits cellular plasticity,…”
Get more information

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade by Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V, Lizotte, Patrick H, Mahadevan, Navin R, Greene, Jonathan R, Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J, Thai, Tran C, Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J, Kirschmeier, Paul T, Liu, David, Giannakis, Marios, Jenkins, Russell W, Gokhale, Prafulla C, Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D, Hammerman, Peter S, Miret, Juan J, Paweletz, Cloud P, Barbie, David A

“…Resistance to oncogene-targeted therapies involves discrete drug-tolerant persister cells, originally discovered through in vitro assays. Whether a similar…”
Get full text

TREX1 Inactivation Unleashes Cancer Cell STING-Interferon Signaling and Promotes Antitumor Immunity by Tani, Tetsuo, Mathsyaraja, Haritha, Campisi, Marco, Li, Ze-Hua, Haratani, Koji, Fahey, Caroline G, Ota, Keiichi, Mahadevan, Navin R, Shi, Yingxiao, Saito, Shin, Mizuno, Kei, Thai, Tran C, Sasaki, Nobunari, Homme, Mizuki, Yusuf, Choudhury Fabliha B, Kashishian, Adam, Panchal, Jipsa, Wang, Min, Wolf, Benjamin J, Barbie, Thanh U, Paweletz, Cloud P, Gokhale, Prafulla C, Liu, David, Uppaluri, Ravindra, Kitajima, Shunsuke, Cain, Jennifer, Barbie, David A

“…A substantial fraction of cancers evade immune detection by silencing Stimulator of Interferon Genes (STING)-Interferon (IFN) signaling. Therapeutic…”
Get more information

Activation of Tumor-Cell STING Primes NK-Cell Therapy by Knelson, Erik H, Ivanova, Elena V, Tarannum, Mubin, Campisi, Marco, Lizotte, Patrick H, Booker, Matthew A, Ozgenc, Ismail, Noureddine, Moataz, Meisenheimer, Brittany, Chen, Minyue, Piel, Brandon, Spicer, Nathaniel, Obua, Bonje, Messier, Cameron M, Shannon, Erin, Mahadevan, Navin R, Tani, Tetsuo, Schol, Pieter J, Lee-Hassett, Anna M, Zlota, Ari, Vo, Ha V, Ha, Minh, Bertram, Arrien A, Han, Saemi, Thai, Tran C, Gustafson, Corinne E, Venugopal, Kartika, Haggerty, Timothy J, Albertson, Thomas P, Hartley, Antja-Voy, Eser, Pinar O, Li, Ze-Hua, Cañadas, Israel, Vivero, Marina, De Rienzo, Assunta, Richards, William G, Abu-Yousif, Adnan O, Appleman, Vicky A, Gregory, Richard C, Parent, Alexander, Lineberry, Neil, Smith, Eric L, Jänne, Pasi A, Miret, Juan J, Tolstorukov, Michael Y, Romee, Rizwan, Paweletz, Cloud P, Bueno, Raphael, Barbie, David A

“…Activation of the stimulator of interferon genes (STING) pathway promotes antitumor immunity but STING agonists have yet to achieve clinical success. Increased…”
Get more information

ALK peptide vaccination restores the immunogenicity of ALK-rearranged non-small cell lung cancer by Mota, Ines, Patrucco, Enrico, Mastini, Cristina, Mahadevan, Navin R, Thai, Tran C, Bergaggio, Elisa, Cheong, Taek-Chin, Leonardi, Giulia, Karaca-Atabay, Elif, Campisi, Marco, Poggio, Teresa, Menotti, Matteo, Ambrogio, Chiara, Longo, Dario L, Klaeger, Susan, Keshishian, Hasmik, Sztupinszki, Zsófia M, Szallasi, Zoltan, Keskin, Derin B, Duke-Cohan, Jonathan S, Reinhold, Bruce, Carr, Steven A, Wu, Catherine J, Moynihan, Kelly D, Irvine, Darrell J, Barbie, David A, Reinherz, Ellis L, Voena, Claudia, Awad, Mark M, Blasco, Rafael B, Chiarle, Roberto

“…Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) is treated with ALK tyrosine kinase inhibitors (TKIs), but the lack of activity…”
Get full text

Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer by Murayama, Takahiko, Mahadevan, Navin R, Meador, Catherine B, Ivanova, Elena V, Pan, Yuqiao, Knelson, Erik H, Tani, Tetsuo, Nakayama, Jun, Ma, Xueying, Thai, Tran C, Hung, Yin P, Kim, William, Watanabe, Hideo, Cai, Kathy Q, Hata, Aaron N, Paweletz, Cloud P, Barbie, David A, Cañadas, Israel

“…Small-cell lung cancer (SCLC) is the most lethal type of lung cancer. Paradoxically, this tumor displays an initial exquisite response to chemotherapy;…”
Get full text

MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6 by Yoshida, Akiyo, Kitajima, Shunsuke, Li, Fengkai, Cheng, Chaoyang, Takegami, Yujiro, Kohno, Susumu, Wan, Yuan Song, Hayashi, Naoyuki, Muranaka, Hayato, Nishimoto, Yuuki, Nagatani, Naoko, Nishiuchi, Takumi, Thai, Tran C, Suzuki, Sawako, Nakao, Shinji, Tanaka, Tomoaki, Hirose, Osamu, Barbie, David A, Takahashi, Chiaki

“…We established an in vitro cell culture system to determine novel activities of the retinoblastoma (Rb) protein during tumor progression. Rb depletion in…”
Get full text

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment by Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin

“…STK11/LKB1 is among the most commonly inactivated tumor suppressors in non-small cell lung cancer (NSCLC), especially in tumors harboring KRAS mutations. Many…”
Get full text