Search Results - "Thai, Khanh K"

Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts by Rashkin, Sara R., Graff, Rebecca E., Kachuri, Linda, Thai, Khanh K., Alexeeff, Stacey E., Blatchins, Maruta A., Cavazos, Taylor B., Corley, Douglas A., Emami, Nima C., Hoffman, Joshua D., Jorgenson, Eric, Kushi, Lawrence H., Meyers, Travis J., Van Den Eeden, Stephen K., Ziv, Elad, Habel, Laurel A., Hoffmann, Thomas J., Sakoda, Lori C., Witte, John S.

“…Deciphering the shared genetic basis of distinct cancers has the potential to elucidate carcinogenic mechanisms and inform broadly applicable risk assessment…”
Get full text

A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci by Choquet, Hélène, Paylakhi, Seyyedhassan, Kneeland, Stephen C., Thai, Khanh K., Hoffmann, Thomas J., Yin, Jie, Kvale, Mark N., Banda, Yambazi, Tolman, Nicholas G., Williams, Pete A., Schaefer, Catherine, Melles, Ronald B., Risch, Neil, John, Simon W. M., Nair, K. Saidas, Jorgenson, Eric

“…Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in…”
Get full text

A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure by Choquet, Hélène, Thai, Khanh K., Yin, Jie, Hoffmann, Thomas J., Kvale, Mark N., Banda, Yambazi, Schaefer, Catherine, Risch, Neil, Nair, K. Saidas, Melles, Ronald, Jorgenson, Eric

“…Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, a leading cause of blindness. IOP heritability has been estimated to up to 67%, and to…”
Get full text

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts by Graff, Rebecca E., Cavazos, Taylor B., Thai, Khanh K., Kachuri, Linda, Rashkin, Sara R., Hoffman, Joshua D., Alexeeff, Stacey E., Blatchins, Maruta, Meyers, Travis J., Leong, Lancelote, Tai, Caroline G., Emami, Nima C., Corley, Douglas A., Kushi, Lawrence H., Ziv, Elad, Van Den Eeden, Stephen K., Jorgenson, Eric, Hoffmann, Thomas J., Habel, Laurel A., Witte, John S., Sakoda, Lori C.

“…Even distinct cancer types share biological hallmarks. Here, we investigate polygenic risk score (PRS)-specific pleiotropy across 16 cancers in European…”
Get full text

Repeat Associated Non-AUG Translation (RAN Translation) Dependent on Sequence Downstream of the ATXN2 CAG Repeat by Scoles, Daniel R, Ho, Mi H T, Dansithong, Warunee, Pflieger, Lance T, Petersen, Lance W, Thai, Khanh K, Pulst, Stefan M

“…Spinocerebellar ataxia type 2 (SCA2) is a progressive autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 disease…”
Get full text

Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system by Fohner, Alison E, Ranatunga, Dilrini K, Thai, Khanh K, Lawson, Brian L, Risch, Neil, Oni-Orisan, Akinyemi, Jelalian, Aline T, Rettie, Allan E, Liu, Vincent X, Schaefer, Catherine A

“…OBJECTIVETo assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment…”
Get full text

Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin‐Induced Cutaneous Adverse Drug Reactions by Fohner, Alison E., Rettie, Allan E., Thai, Khanh K., Ranatunga, Dilrini K., Lawson, Brian L., Liu, Vincent X., Schaefer, Catherine A.

“…The role of cytochrome P450 (CYP)2C9 and CYP2C19 genetic variation in risk for phenytoin‐induced cutaneous adverse drug events is not well understood…”
Get full text

Development of a healthcare system COVID Hotspotting Score in California: an observational study with prospective validation by Liu, Vincent X, Thai, Khanh K, Galin, Jessica, Gerstley, Lawrence David, Myers, Laura C, Parodi, Stephen M, Chen, Yi-Fen Irene, Goler, Nancy, Escobar, Gabriel J, Kipnis, Patricia

“…ObjectiveTo examine the value of health systems data as indicators of emerging COVID-19 activity.DesignObservational study of health system indicators for the…”
Get full text

Prognostic Accuracy of Presepsis and Intrasepsis Characteristics for Prediction of Cardiovascular Events After a Sepsis Hospitalization by Walkey, Allan J, Knox, Daniel B, Myers, Laura C, Thai, Khanh K, Jacobs, Jason R, Kipnis, Patricia, Desai, Manisha, Go, Alan S, Lu, Yun, Brown, Samuel M, Martinez, Adriana, Clancy, Heather, Devis, Ycar, Liu, Vincent X

“…Sepsis survivors face increased risk for cardiovascular complications; however, the contribution of intrasepsis events to cardiovascular risk profiles is…”
Get full text

Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia by Hysi, Pirro G., Choquet, Hélène, Khawaja, Anthony P., Wojciechowski, Robert, Tedja, Milly S., Yin, Jie, Simcoe, Mark J., Patasova, Karina, Mahroo, Omar A., Thai, Khanh K., Cumberland, Phillippa M., Melles, Ronald B., Verhoeven, Virginie J. M., Vitart, Veronique, Segre, Ayellet, Stone, Richard A., Wareham, Nick, Hewitt, Alex W., Mackey, David A., Klaver, Caroline C. W., MacGregor, Stuart, Khaw, Peng T., Foster, Paul J., Guggenheim, Jeremy A., Rahi, Jugnoo S., Jorgenson, Eric, Hammond, Christopher J.

“…Refractive errors, in particular myopia, are a leading cause of morbidity and disability worldwide. Genetic investigation can improve understanding of the…”
Get full text

Amyotrophic lateral sclerosis risk for spinocerebellar ataxia type 2 ATXN2 CAG repeat alleles: a meta-analysis by Neuenschwander, Annalese G, Thai, Khanh K, Figueroa, Karla P, Pulst, Stefan M

“…Repeats of CAG in the ataxin 2 gene (ATXN2) in the long-normal range (sometimes referred to as intermediate) have been identified as modifiers of amyotrophic…”
Get more information

Development and Validation of a Diabetic Retinopathy Risk Stratification Algorithm by Tarasewicz, Dariusz, Karter, Andrew J, Pimentel, Noel, Moffet, Howard H, Thai, Khanh K, Schlessinger, David, Sofrygin, Oleg, Melles, Ronald B

“…Although diabetic retinopathy is a leading cause of blindness worldwide, diabetes-related blindness can be prevented through effective screening, detection,…”
Get full text

Association between Troponin I Levels during Sepsis and Postsepsis Cardiovascular Complications by Garcia, Michael A, Rucci, Justin M, Thai, Khanh K, Lu, Yun, Kipnis, Patricia, Go, Alan S, Desai, Manisha, Bosch, Nicholas A, Martinez, Adriana, Clancy, Heather, Devis, Ycar, Myers, Laura C, Liu, Vincent X, Walkey, Allan J

“…Sepsis commonly results in elevated serum troponin levels and increased risk for postsepsis cardiovascular complications; however, the association between…”
Get full text

Trends and Risk Factors for Venous Thromboembolism Among Hospitalized Medical Patients by Neeman, Elad, Liu, Vincent, Mishra, Pranita, Thai, Khanh K, Xu, James, Clancy, Heather A, Schlessinger, David, Liu, Raymond

“…While hospital-associated venous thromboembolism (HA-VTE) is a known complication of hospitalization, contemporary incidence and outcomes data are scarce and…”
Get full text

Hospital‐associated venous thromboembolism prophylaxis use by risk assessment at a large integrated health care network in Northern California by Xu, James, Neeman, Elad, Thai, Khanh K., Mishra, Pranita, Schlessinger, David, Clancy, Heather, Myers, Laura, Roubinian, Nareg, Liu, Vincent, Liu, Raymond

“…Background Hospital‐acquired venous thromboembolism (HA VTE) is a preventable complication in hospitalized patients. Objective We aimed to examine the use of…”
Get full text

Practice Patterns and Outcomes Associated With Anticoagulation Use Following Sepsis Hospitalizations With New-Onset Atrial Fibrillation by Walkey, Allan J., Myers, Laura C., Thai, Khanh K., Kipnis, Patricia, Desai, Manisha, Go, Alan S., Lu, Yun, Clancy, Heather, Devis, Ycar, Neugebauer, Romain, Liu, Vincent X.

“…Practice patterns and outcomes associated with the use of oral anticoagulation for arterial thromboembolism prevention following a hospitalization with…”
Get full text

Predicting Cardiovascular Events after Sepsis with Death as a Competing Risk by Myers, Laura C, Knox, Daniel, Thai, Khanh K, Kipnis, Patricia, Jacobs, Jason, Lee, Catherine, Desai, Manisha, Devis, Ycar, Clancy, Heather, Lu, Yun W, Go, Alan S, Liu, Vincent X, Walkey, Allan J

Get full text

Population-based risks for cancer in patients with ALS by Gibson, Summer B, Abbott, Diana, Farnham, James M, Thai, Khanh K, McLean, Hailey, Figueroa, Karla P, Bromberg, Mark B, Pulst, Stefan M, Cannon-Albright, Lisa

“…OBJECTIVE:To estimate the risks for cancer (overall and site-specific) in an amyotrophic lateral sclerosis (ALS) cohort. METHODS:In this observational…”
Get full text

Genetic variation in the SIM1 locus is associated with erectile dysfunction by Jorgenson, Eric, Matharu, Navneet, Palmer, Melody R., Yin, Jie, Shan, Jun, Hoffmann, Thomas J., Thai, Khanh K., Zhou, Xujia, Hotaling, James M., Jarvik, Gail P., Ahituv, Nadav, Wessells, Hunter, Van Den Eeden, Stephen K.

“…Erectile dysfunction affects millions of men worldwide. Twin studies support the role of genetic risk factors underlying erectile dysfunction, but no specific…”
Get full text

Predicting stroke risk after sepsis hospitalization with new-onset atrial fibrillation by Myers, Laura C, Peltan, Ithan D, Thai, Khanh K, Kipnis, Patricia, Desai, Manisha, Devis, Ycar, Clancy, Heather, Lu, Yun W, Brown, Samuel M, Go, Alan S, Neugebauer, Romain S, Liu, Vincent X, Walkey, Allan J

“…New-onset atrial fibrillation (AF) during sepsis is common, but models designed to stratify stroke risk excluded patients with secondary AF. We assessed the…”
Get full text