Search Results - "Thaete, Larry G"

Progestins inhibit calcitriol-induced CYP24A1 and synergistically inhibit ovarian cancer cell viability: An opportunity for chemoprevention by Rodriguez, Gustavo C, Turbov, Jane, Rosales, Rebecca, Yoo, Jennifer, Hunn, Jessica, Zappia, Katherine J, Lund, Kaarin, Barry, Catherine P, Rodriguez, Isabel V, Pike, J. Wesley, Conrads, Thomas P, Darcy, Kathleen M, Maxwell, George Larry, Hamilton, Chad A, Syed, Viqar, Thaete, Larry G

“…Abstract Objectives Previously we have shown in endometrial cells that progesterone (P4) and calcitriol (CAL, 1,25(OH)2 D3 ) synergistically promote apoptosis…”
Get full text

The Fetal Response to Chronic Placental Insufficiency by Neerhof, Mark G., DO, Thaete, Larry G., PhD

“…Fetal growth restriction is most commonly caused by failure of the placenta to meet the increasing demands for oxygen and substrate of the developing fetus,…”
Get full text

Progesterone Enhances Calcitriol Antitumor Activity by Upregulating Vitamin D Receptor Expression and Promoting Apoptosis in Endometrial Cancer Cells by LEE, Laura R, TENG, Pang-Ning, RODRIGUEZ, Gustavo C, CONRADS, Thomas P, SYED, Viqar, NGUYEN, Huyen, HOOD, Brian L, KAVANDI, Leyla, GUISONG WANG, TURBOV, Jane M, THAETE, Larry G, HAMILTON, Chad A, MAXWELL, George L

“…Human studies suggest that progesterone and calcitriol may prove beneficial in preventing or inhibiting oncogenesis, but the underlying mechanism is not fully…”
Get full text

Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth by Kim, Josephine S., Turbov, Jane, Rosales, Rebecca, Thaete, Larry G., Rodriguez, Gustavo C.

“…Recent data show that simvastatin (SIM) and metformin (MET) have anti-proliferative effects in endometrial cancer cells. The combination (MET+SIM) inhibits…”
Get full text

Unilateral uterine ischemia/reperfusion-induced bilateral fetal loss and fetal growth restriction in a murine model require intact complement component 5 by Qu, Xiao-Wu, Jilling, Tamas, Neerhof, Mark G, Luo, Kehuan, Hirsch, Emmet, Thaete, Larry G

“…Abstract The role of complement in ischemia/reperfusion-induced fetal growth restriction and fetal loss is unknown. C5-deficient or wild type timed-pregnant…”
Get full text

Nonsteroidal antiinflammatory drugs and progestins synergistically enhance cell death in ovarian epithelial cells by Rodriguez, Gustavo C., MD, Turbov, Jane M., MLS, Berchuck, Andrew, MD, Stack, M. Sharon, PhD, Hurteau, Jean A., MD, Thaete, Larry G., PhD, Barry, Catherine P., PhD

“…Objective There is growing evidence that progestins and nonsteroidal antiinflammatory drugs (NSAIDs) may prevent ovarian cancer. Because both induce apoptosis,…”
Get full text

Expression of Endothelin 1 and Its Receptors in the Hypoxic Pregnant Rat by Thaete, Larry G, Jilling, Tamas, Synowiec, Sylvia, Khan, Saira, Neerhof, Mark G

“…Endothelin 1 (EDN1) plays a primary role in the pathophysiology of hypoxia-induced fetal growth restriction in the rat. In this study we evaluated the effects…”
Get full text

Vitamin D Significantly Inhibits Carcinogenesis in the Mogp-TAg Mouse Model of Fallopian Tube Ovarian Cancer by Nelson, Omar L, Rosales, Rebecca, Turbov, Jane, Thaete, Larry G, Balamayooran, Gayathriy, Cline, J Mark, Pike, J Wesley, Rodriguez, Gustavo C

“…Epidemiological and observational studies suggest that vitamin D has potential for the chemoprevention of ovarian cancer. The anticancer effect of vitamin D in…”
Get full text

Progestin Significantly Inhibits Carcinogenesis in the Mogp-TAg Transgenic Mouse Model of Fallopian Tube Cancer by Nelson, Omar L, Rosales, Rebecca, Turbov, Jane M, Thaete, Larry G, Cline, J Mark, Rodriguez, Gustavo C

“…Recent studies suggest that the fallopian tube epithelium (FTE) harbors the precursor for high-grade ovarian cancer, creating opportunities for targeting the…”
Get full text

Endothelin Receptor A Antagonism Prevents Damage to Glycogen-Rich Placental Cells Following Uterine Ischemia-Reperfusion in the Rat by Thaete, Larry G, Khan, Saira, Neerhof, Mark G

“…Fetal growth restriction (FGR) is a common cause of perinatal morbidity and mortality. Suboptimal uteroplacental perfusion is the most commonly identified…”
Get more information

Endothelin Receptor A Antagonism and Fetal Growth in Endothelial Nitric Oxide Synthase Gene Knockout Maternal and Fetal Mice by Luo, Kehuan, Thaete, Larry G, Neerhof, Mark G

“…Fetal growth restriction (FGR) is commonly associated with perinatal morbidity and mortality. Nitric oxide (NO) deficiency increases endothelin-1 (ET-1)…”
Get more information

Fetal Growth Restriction Induced by Transient Uterine Ischemia-Reperfusion: Differential Responses in Different Mouse Strains by Thaete, Larry G, Qu, Xiao-Wu, Neerhof, Mark G, Hirsch, Emmet, Jilling, Tamas

“…We characterized fetal and placental growth and uterine and placental inflammation in pregnant C3H/HeOuJ and C57BL/6J mice (strains with different…”
Get more information

Phase II Trial of Chemopreventive Effects of Levonorgestrel on Ovarian and Fallopian Tube Epithelium in Women at High Risk for Ovarian Cancer: An NRG Oncology Group/GOG Study by Rodriguez, Gustavo C, Kauderer, James, Hunn, Jessica, Thaete, Larry G, Watkin, William G, Russell, Samantha, Yozwiak, Michael, Basil, Jack, Hurteau, Jean, Lele, Shashikant, Modesitt, Susan C, Zivanovic, Oliver, Zhang, Hao Helen, Bartels, Peter H, Alberts, David S

“…A large body of epidemiologic evidence has shown that use of progestin-containing preparations lowers ovarian cancer risk. The purpose of the current study was…”
Get full text

Endothelin receptor antagonist has limited access to the fetal compartment during chronic maternal administration late in pregnancy by Thaete, Larry G., Khan, Saira, Synowiec, Sylvia, Dayton, Brian D., Bauch, Joy, Neerhof, Mark G.

“…Endothelin receptor A (ETA) antagonism normalizes fetal growth in several models of rodent fetal growth restriction (FGR). Our aims were to determine the…”
Get full text

Impact of anaesthetics and analgesics on fetal growth in the mouse by Thaete, Larry G, Levin, Stephen I, Dudley, Andrew T

“…Common anaesthetic and analgesic agents used during pregnancy in mice have been observed to cause fetal growth restriction. We investigated the impact of…”
Get full text

Pathophysiology of Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat by Neerhof, Mark G., Synowiec, Sylvia, Khan, Saira, Thaete, Larry G.

“…Objective. To evaluate the pathophysiology of chronic nitric oxide synthase (NOS) inhibition-induced fetal growth restriction (FGR) in the rat. Methods…”
Get full text

The significance of endothelin in platelet-activating factor-induced fetal growth restriction by Neerhof, Mark G, Khan, Saira, Synowiec, Sylvia, Qu, Xiao-Wu, Thaete, Larry G

“…The significance of endothelin-1 (ET-1) in platelet-activating factor (PAF)-induced fetal growth restriction (FGR) was evaluated in timed-pregnant rats…”
Get more information

Impact of toll-like receptor 4 deficiency on the response to uterine ischemia/reperfusion in mice by Thaete, Larry G, Qu, Xiao-Wu, Jilling, Tamas, Crawford, Susan E, Fitchev, Philip, Hirsch, Emmet, Khan, Saira, Neerhof, Mark G

“…Our objective was to determine the role of toll-like receptor 4 (TLR4) in uterine ischemia/reperfusion (I/R)-induced fetal growth restriction (FGR). Pregnant…”
Get full text

Endothelin and platelet-activating factor: Significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat by Thaete, Larry G., Neerhof, Mark G.

“…The objective of the study was to evaluate the role of endothelin-1 and platelet-activating factor in ischemia/reperfusion-induced fetal growth restriction in…”
Get full text

Impact of Endothelin A Receptor Antagonist Selectivity in Chronic Nitric Oxide Synthase Inhibition-Induced Fetal Growth Restriction in the Rat by Neerhof, Mark G., Synowiec, Sylvia, Khan, Saira, Thaete, Larry G.

“…Objective: Endothelin receptor A (ETA) antagonism improves fetal and placental growth and placental perfusion on days 1 and 4, but not day 7 of a 7-day…”
Get full text