Rosai-dorfman disease of the pleura: a rare extranodal presentation

We present a case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) manifesting primarily as a pleural disease without involvement of the lung parenchyma. The patient is an 81-year-old man who presented with increasing shortness of breath. Radiographic studies revealed a la...

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Bibliographic Details
Published in:	Human pathology Vol. 34; no. 11; pp. 1210 - 1211
Main Authors:	Ohori, N.Paul, Yu, Jing, Landreneau, Rodney J, Thaete, F.Leland, Kane, Kevin
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-11-2003 Elsevier Elsevier Limited
Subjects:	Aged Aged, 80 and over Airway management Biological and medical sciences Disease Hematologic and hematopoietic diseases Histiocytes - metabolism Histiocytes - pathology Histiocytosis, Sinus - complications Histiocytosis, Sinus - metabolism Histiocytosis, Sinus - pathology Humans Male Medical diagnosis Medical sciences Other diseases. Hematologic involvement in other diseases pleura Pleural Diseases - complications Pleural Diseases - metabolism Pleural Diseases - pathology Pleural Effusion - etiology Pneumology Respiratory system : syndromes and miscellaneous diseases Rosai-Dorfman disease S100 Proteins - metabolism sinus histiocytosis with massive lymphadenopathy sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease pleura Human Case study Immunohistochemistry Anatomic pathology Rosai Dorfman disease Respiratory disease Pleural disease Hemopathy Elderly Pleura
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Summary:	We present a case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) manifesting primarily as a pleural disease without involvement of the lung parenchyma. The patient is an 81-year-old man who presented with increasing shortness of breath. Radiographic studies revealed a large loculated left-sided pleural effusion and parietal pleural thickening. Video-assisted thoracoscopic biopsy of the pleura showed the characteristic S100-positive histiocytes exhibiting emperipolesis. In this rare case of pleural Rosai-Dorfman disease, the extensive involvement of the pleural lymphatics by the characteristic histiocytes appears to have been responsible for the pleural effusion.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0046-8177 1532-8392
DOI:	10.1016/S0046-8177(03)00402-7