Search Results - "Thadeio, Peter F"

Biological Spectra Analysis: Linking Biological Activity Profiles to Molecular Structure by Fliri, Anton F., Loging, William T., Thadeio, Peter F., Volkmann, Robert A., Overman, Larry E.

“…Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no…”
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A framework for setting enrollment goals to ensure participant diversity in sponsored clinical trials in the United States by Cullen, Mark R., Lemeshow, Adina R., Amaro, Sandra, Bandera, Elisa V., Cooper, Lisa A., Kawachi, Ichiro, Lunyera, Joseph, McKinley, Laura, Poss, Christopher S., Rottas, Melinda M., Schachterle, Stephen E., Thadeio, Peter F., Russo, Leo J.

“…Diversity in clinical trials (CTs) has the potential to improve health equity and close health disparities. Underrepresentation of historically underserved…”
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Discovery of a potent substance P antagonist: recognition of the key molecular determinant by Desai, Manoj C, Lefkowitz, Sheri L, Thadeio, Peter F, Longo, Kelly P, Snider, R. Michael

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Analysis of drug-induced effect patterns to link structure and side effects of medicines by Fliri, Anton F, Volkmann, Robert A, Loging, William T, Thadeio, Peter F

“…The high failure rate of experimental medicines in clinical trials accentuates inefficiencies of current drug discovery processes caused by a lack of tools for…”
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Biospectra Analysis:  Model Proteome Characterizations for Linking Molecular Structure and Biological Response by Fliri, Anton F, Loging, William T, Thadeio, Peter F, Volkmann, Robert A

“…Establishing quantitative relationships between molecular structure and broad biological effects has been a long-standing goal in drug discovery. Evaluation of…”
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Disulfide Bond Assignment of .omega.-Agatoxins IVB and IVC: Discovery of a D-Serine Residue in .omega.-Agatoxin IVB by Heck, Steven D, Kelbaugh, Paul R, Kelly, Mary E, Thadeio, Peter F, Saccomano, Nicholas A, Stroh, Justin G, Volkmann, Robert A

“…A TCEP (tris(2-carboxyethyl)phosphine)-based reduction/cysteine amidoalkylation strategy was utilized to solve the disulfide structures of omega -agatoxins IVB…”
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Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding by Vinick, Fredric J, Saccomano, Nicholas A, Koe, B. Kenneth, Nielsen, Jann A, Williams, Ian H, Thadeio, Peter F, Jung, Stanley, Meltz, Morgan, Johnson, Jonathan, Lebel, Lorraine A, Russo, Lorena L, Helweg, David

“…The synthesis and biological properties of a series of nicotinamide ethers are described. These compounds, structurally novel calcium-independent…”
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Posttranslational Amino Acid Epimerization: Enzyme-Catalyzed Isomerization of Amino Acid Residues in Peptide Chains by Heck, Steven D., Faraci, W. Stephen, Kelbaugh, Paul R., Saccomano, Nicholas A., Thadeio, Peter F., Volkmann, Robert A.

“…Since ribosomally mediated protein biosynthesis is confined to the L-amino acid pool, the presence of D-amino acids in peptides was considered for many years…”
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Functional Consequences of Posttranslation Isomerization of Ser$^{46}$ in a Calcium Channel Toxin by Heck, Steven D., Siok, Chester J., Krapcho, Karen J., Kelbaugh, Paul R., Thadeio, Peter F., Welch, Melissa J., Williams, Robert D., Ganong, Alan H., Kelly, Mary E., Lanzetti, Anthony J., Gray, William R., Phillips, Douglas, Parks, Thomas N., Jackson, Hunter, Ahlijanian, Michael K., Saccomano, Nicholas A., Volkmann, Robert A.

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
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Functional Consequences of Posttranslational Isomerization of Ser 46 in a Calcium Channel Toxin by Heck, Steven D., Siok, Chester J., Krapcho, Karen J., Kelbaugh, Paul R., Thadeio, Peter F., Welch, Melissa J., Williams, Robert D., Ganong, Alan H., Kelly, Mary E., Lanzetti, Anthony J., Gray, William R., Phillips, Douglas, Parks, Thomas N., Jackson, Hunter, Ahlijanian, Michael K., Saccomano, Nicholas A., Volkmann, Robert A.

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
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Functional consequences of posttranslational isomerization of Ser46 in a calcium channel toxin by HECK, S. D, SIOK, C. J, GRAY, W. R, PHILLIPS, D, PARKS, T. N, JACKSON, H, AHLIJANIAN, M. K, SACCOMANO, N. A, VOLKMANN, R. A, KRAPCHO, K. J, KELBAUGH, P. R, THADEIO, P. F, WELCH, M. J, WILLIAMS, R. D, GANONG, A. H, KELLY, M. E, LANZETTI, A. J

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
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