Search Results - "Thackray, Varykina G."

Sex, Microbes, and Polycystic Ovary Syndrome by Thackray, Varykina G.

“…Recent studies have shown that sex and sex steroids influence the composition of the gut microbiome. These studies also indicate that steroid regulation of the…”
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The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome by Kelley, Scott T, Skarra, Danalea V, Rivera, Alissa J, Thackray, Varykina G

“…Women with polycystic ovary syndrome (PCOS) have reproductive and metabolic abnormalities that result in an increased risk of infertility, diabetes and…”
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Hyperactive LH Pulses and Elevated Kisspeptin and NKB Gene Expression in the Arcuate Nucleus of a PCOS Mouse Model by Esparza, Lourdes A, Schafer, Danielle, Ho, Brian S, Thackray, Varykina G, Kauffman, Alexander S

“…Abstract Polycystic ovary syndrome (PCOS), a common reproductive disorder in women, is characterized by hyperandrogenemia, chronic anovulation, cystic ovarian…”
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Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome by Arroyo, Pablo, Ho, Bryan S, Sau, Lillian, Kelley, Scott T, Thackray, Varykina G

“…Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-aged women that is comprised of two out of the following three features:…”
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Intersection of Polycystic Ovary Syndrome and the Gut Microbiome by Rizk, Maryan G, Thackray, Varykina G

“…Abstract The etiology of polycystic ovary syndrome (PCOS) remains unclear, although studies indicate that both genetic and environmental factors contribute to…”
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Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model by Torres, Pedro J, Ho, Bryan S, Arroyo, Pablo, Sau, Lillian, Chen, Annie, Kelley, Scott T, Thackray, Varykina G

“…Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting ∼10% to 15% of reproductive-aged women worldwide. Diagnosis requires two of the…”
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Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults by de la Cuesta-Zuluaga, Jacobo, Kelley, Scott T, Chen, Yingfeng, Escobar, Juan S, Mueller, Noel T, Ley, Ruth E, McDonald, Daniel, Huang, Shi, Swafford, Austin D, Knight, Rob, Thackray, Varykina G

“…Gut microbial diversity changes throughout the human life span and is known to be associated with host sex. We investigated the association of age, sex, and…”
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Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance by Skarra, Danalea V, Hernández-Carretero, Angelina, Rivera, Alissa J, Anvar, Arya R, Thackray, Varykina G

“…Abstract Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic…”
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Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice by Torres, Pedro J, Skarra, Danalea V, Ho, Bryan S, Sau, Lillian, Anvar, Arya R, Kelley, Scott T, Thackray, Varykina G

“…A majority of women with polycystic ovary syndrome (PCOS) have metabolic dysfunction that results in an increased risk of type 2 diabetes. We previously…”
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Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB by Bohaczuk, Stephanie C, Cassin, Jessica, Slaiwa, Theresa I, Thackray, Varykina G, Mellon, Pamela L

“…Abstract FSH is critical for fertility. Transcription of FSHB, the gene encoding the beta subunit, is rate-limiting in FSH production and is regulated by both…”
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Insulin‐induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice by McCosh, Richard B., Kreisman, Michael J., Tian, Katherine, Ho, Bryan S., Thackray, Varykina G., Breen, Kellie M.

“…Stress suppresses pulsatile luteinising hormone (LH) secretion in a variety of species, although the mechanism underlying this inhibition of reproductive…”
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Metabolic dysregulation and gut dysbiosis linked to hyperandrogenism in female mice by Chen, Annie, Handzel, Alex, Sau, Lillian, Cui, Laura, Kelley, Scott T., Thackray, Varykina G.

“…Introduction Polycystic ovary syndrome (PCOS) is a common endocrine pathology in women. In addition to infertility, women with PCOS have metabolic…”
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Genetic hypogonadal mouse model reveals niche-specific influence of reproductive axis and sex on intestinal microbial communities by Sisk-Hackworth, Laura, Brown, Jada, Sau, Lillian, Levine, Andrew A, Tam, Lai Ying Ivy, Ramesh, Aishwarya, Shah, Reeya S, Kelley-Thackray, Evelyn T, Wang, Sophia, Nguyen, Anita, Kelley, Scott T, Thackray, Varykina G

“…The gut microbiome has been linked to many diseases with sex bias including autoimmune, metabolic, neurological, and reproductive disorders. While numerous…”
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Gut Metabolites Are More Predictive of Disease and Cohoused States than Gut Bacterial Features in a Polycystic Ovary Syndrome-Like Mouse Model by Ho, Bryan, Ryback, Daniel, Benson, Basilin, Mason, Cayla N., Torres, Pedro J., Quinn, Robert A., Thackray, Varykina G., Kelley, Scott T.

“…Polycystic ovary syndrome (PCOS) impacts ∼10% of reproductive-aged women worldwide. In addition to infertility, women with PCOS suffer from metabolic…”
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Harnessing the power within: engineering the microbiome for enhanced gynecologic health by Brennan, Caitriona, Chan, Kristina, Kumar, Tanya, Maissy, Erica, Brubaker, Linda, Dothard, Marisol I, Gilbert, Jack A, Gilbert, Katharine E, Lewis, Amanda L, Thackray, Varykina G, Zarrinpar, Amir, Knight, Rob

“…Although numerous studies have demonstrated the impact of microbiome manipulation on human health, research on the microbiome's influence on female health…”
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Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism by Torres, Pedro J, Siakowska, Martyna, Banaszewska, Beata, Pawelczyk, Leszek, Duleba, Antoni J, Kelley, Scott T, Thackray, Varykina G

“…Abstract Context A majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities that result in an increased risk of developing type 2…”
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Constitutively active FOXO1 diminishes activin induction of Fshb transcription in immortalized gonadotropes by Park, Chung Hyun, Skarra, Danalea V, Rivera, Alissa J, Arriola, David J, Thackray, Varykina G

“…In the present study, we investigate whether the FOXO1 transcription factor modulates activin signaling in pituitary gonadotropes. Our studies show that…”
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Sex, puberty, and the gut microbiome by Sisk-Hackworth, Laura, Kelley, Scott T, Thackray, Varykina G

“…In brief Sex differences in the gut microbiome may impact multiple aspects of human health and disease. In this study, we review the evidence for microbial sex…”
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A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice1 by Kauffman, Alexander S, Thackray, Varykina G, Ryan, Genevieve E, Tolson, Kristen P, Glidewell-Kenney, Christine A, Semaan, Sheila J, Poling, Matthew C, Iwata, Nahoko, Breen, Kellie M, Duleba, Antoni J, Stener-Victorin, Elisabet, Shimasaki, Shunichi, Webster, Nicholas J, Mellon, Pamela L

“…Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder…”
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Fox tales: Regulation of gonadotropin gene expression by forkhead transcription factors by Thackray, Varykina G.

“…•Loss of FOXD1 in the pituitary mesenchyme results in decreased Lhb transcription.•FOXL2 is essential for activin-induced Fshb transcription and FSH…”
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