Search Results - "Thackray, Alana M"

The emergence of classical BSE from atypical/Nor98 scrapie by Huor, Alvina, Espinosa, Juan Carlos, Vidal, Enric, Cassard, Hervé, Douet, Jean-Yves, Lugan, Séverine, Aron, Naima, Marín-Moreno, Alba, Lorenzo, Patricia, Aguilar-Calvo, Patricia, Badiola, Juan, Bolea, Rosa, Pumarola, Martí, Benestad, Sylvie L., Orge, Leonore, Thackray, Alana M., Bujdoso, Raymond, Torres, Juan-Maria, Andreoletti, Olivier

“…Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and,…”
Get full text

Direct Observation of Murine Prion Protein Replication in Vitro by Sang, Jason C, Meisl, Georg, Thackray, Alana M, Hong, Liu, Ponjavic, Aleks, Knowles, Tuomas P. J, Bujdoso, Raymond, Klenerman, David

“…Prions are believed to propagate when an assembly of prion protein (PrP) enters a cell and replicates to produce two or more fibrils, leading to an exponential…”
Get full text

Emergence of multiple prion strains from single isolates of ovine scrapie by THACKRAY, Alana M, HOPKINS, Lee, LOCKEY, Richard, SPIROPOULOS, John, BUJDOSO, Raymond

“…The infectious agent associated with prion diseases such as ovine scrapie shows strain diversity. Ovine prion strains have typically been identified by their…”
Get full text

Prion-induced and spontaneous formation of transmissible toxicity in PrP transgenic Drosophila by Thackray, Alana M, Di, Ying, Zhang, Chang, Wolf, Hanna, Pradl, Lydia, Vorberg, Ina, Andréoletti, Olivier, Bujdoso, Raymond

“…Prion diseases are fatal transmissible neurodegenerative diseases of various mammalian species. Central to these conditions is the conversion of the normal…”
Get more information

Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay by Thackray, Alana M, Hopkins, Lee, Bujdoso, Raymond

“…PrPSc [abnormal disease-specific conformation of PrP (prion-related protein)] accumulates in prion-affected individuals in the form of amorphous aggregates…”
Get full text

Molecular and Transmission Characteristics of Primary-Passaged Ovine Scrapie Isolates in Conventional and Ovine PrP Transgenic Mice by THACKRAY, Alana M, HOPKINS, Lee, SPIROPOULOS, John, BUJDOSO, Raymond

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The use of PrP transgenic Drosophila to replace and reduce vertebrate hosts in the bioassay of mammalian prion infectivity [version 1; peer review: 2 approved] by Thackray, Alana M, Andréoletti, Olivier, Bujdoso, Raymond

“…Prion diseases are fatal neurodegenerative conditions of humans and vertebrate species. The transmissible prion agent is a novel infectious particle composed…”
Get full text

Ovine PrP transgenic Drosophila show reduced locomotor activity and decreased survival by Thackray, Alana M, Muhammad, Farooq, Zhang, Chang, Di, Ying, Jahn, Thomas R, Landgraf, Matthias, Crowther, Damian C, Evers, Jan Felix, Bujdoso, Raymond

“…Drosophila have emerged as a model system to study mammalian neurodegenerative diseases. In the present study we have generated Drosophila transgenic for ovine…”
Get more information

Mouse-Adapted Ovine Scrapie Prion Strains Are Characterized by Different Conformers of PrPSc by THACKRAY, Alana M, HOPKINS, Lee, KLEIN, Michael A, BUJDOSO, Raymond

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

A new model for sensitive detection of zoonotic prions by PrP transgenic Drosophila by Thackray, Alana M., Andréoletti, Olivier, Spiropoulos, John, Bujdoso, Raymond

“…Prions are transmissible protein pathogens most reliably detected by a bioassay in a suitable host, typically mice. However, the mouse bioassay is slow and…”
Get full text

The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2 by Fitzmaurice, Tim J, Burke, David F, Hopkins, Lee, Yang, Sujeong, Yu, Shuiliang, Sy, Man-Sun, Thackray, Alana M, Bujdoso, Raymond

“…Susceptibility to scrapie disease in sheep, the archetypal prion disease, correlates with polymorphisms within the ovine PrP (prion-related protein) gene. The…”
Get more information

Prion disease modelled in Drosophila by Bujdoso, Raymond, Smith, Andrew, Fleck, Oliver, Spiropoulos, John, Andréoletti, Olivier, Thackray, Alana M.

“…Prion diseases are fatal neurodegenerative conditions of humans and various vertebrate species that are transmissible between individuals of the same or…”
Get full text

Bioassay of prion-infected blood plasma in PrP transgenic Drosophila by Thackray, Alana M, Andreoletti, Olivier, Bujdoso, Raymond

“…In pursuit of a tractable bioassay to assess blood prion infectivity, we have generated prion protein (PrP) transgenic Drosophila, which show a neurotoxic…”
Get more information

Mammalian prion propagation in PrP transgenic Drosophila by Thackray, Alana M, Andréoletti, Olivier, Bujdoso, Raymond

“…Thackray et al. show authentic propagation of mammalian prions in Drosophila melanogaster rendered transgenic solely for PrP. The molecular and cellular…”
Get full text

Accelerated Prion Disease in the Absence of Interleukin-10 by THACKRAY, Alana M, MCKENZIE, Andrew N, KLEIN, Michael A, LAUDER, Angus, BUJDOSO, Raymond

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Single Protein Molecule Detection by Glass Nanopores by Li, Wenhong, Bell, Nicholas A. W, Hernández-Ainsa, Silvia, Thacker, Vivek V, Thackray, Alana M, Bujdoso, Raymond, Keyser, Ulrich F

“…Nanopores can be used to detect and analyze single molecules in solution. We have used glass nanopores made by laser-assisted capillary-pulling, as a…”
Get full text

Chronic Subclinical Prion Disease Induced by Low-Dose Inoculum by Thackray, Alana M, Klein, Michael A, Aguzzi, Adriano, Bujdoso, Raymond

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Ovine plasma prion protein levels show genotypic variation detected by C-terminal epitopes not exposed in cell-surface PrPC by Thackray, Alana M, Fitzmaurice, Tim J, Hopkins, Lee, Bujdoso, Raymond

“…Ovine PBMCs (peripheral blood mononuclear cells) express PrP(C) [cellular PrP (prion-related protein)] and have the potential to harbour and release…”
Get full text

Lack of prion transmission barrier in human PrP transgenic Drosophila by Thackray, Alana M., McNulty, Erin E., Nalls, Amy V., Smith, Andrew, Comoy, Emmanuel, Telling, Glenn, Benestad, Sylvie L., Andréoletti, Olivier, Mathiason, Candace K., Bujdoso, Raymond

“…While animal prion diseases are a threat to human health, their zoonotic potential is generally inefficient because of interspecies prion transmission…”
Get full text

Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease by Thackray, Alana M, Lam, Brian, Shahira Binti Ab Razak, Anisa, Yeo, Giles, Bujdoso, Raymond

“…Prion diseases are fatal transmissible neurodegenerative conditions of humans and animals that arise through neurotoxicity induced by PrP misfolding. The…”
Get more information