Search Results - "Thach, Danny Q"
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Cyclic Ether Synthesis via Palladium-Catalyzed Directed Dehydrogenative Annulation at Unactivated Terminal Positions
Published in Journal of the American Chemical Society (16-09-2015)“…Here, a palladium-catalyzed functionalization of unactivated sp3 C–H bonds with internal alcohol nucleophiles is described. Directed by an oxime-masked…”
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Classics in Chemical Neuroscience: Donepezil
Published in ACS chemical neuroscience (16-01-2019)“…The discovery of acetylcholine and acetylcholinesterase provided the first insight into the intricacies of chemical signal transduction and neuronal…”
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Making light work of lignan synthesis
Published in Nature chemistry (01-01-2021)“…Mimicking biosynthetic pathways can provide access to medicinally important natural products, but generating the reactive species used by nature can often be…”
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Annulative Methods in the Synthesis of Complex Meroterpene Natural Products
Published in Accounts of chemical research (02-02-2021)“…Conspectus From the venerable Robinson annulation to the irreplaceable Diels–Alder cycloaddition, annulation reactions have fueled the progression of the field…”
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Total Synthesis of (+)‐6‐epi‐Ophiobolin A
Published in Angewandte Chemie International Edition (20-01-2020)“…The ophiobolin sesterterpenes are notable plant pathogens which have recently elicited significant chemical and biological attention because of their…”
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Syntheses of Complex Terpenes from Simple Polyprenyl Precursors
Published in Accounts of chemical research (21-04-2020)“…Conspectus From structure elucidation and biogenesis to synthetic methodology and total synthesis, terpene natural products have profoundly influenced the…”
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Ophiobolin A Covalently Targets Mitochondrial Complex IV Leading to Metabolic Collapse in Cancer Cells
Published in ACS chemical biology (21-06-2024)“…Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity. While OPA possesses multiple electrophilic moieties that can…”
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Total Synthesis of (+)‐6‐epi‐Ophiobolin A
Published in Angewandte Chemie (20-01-2020)“…The ophiobolin sesterterpenes are notable plant pathogens which have recently elicited significant chemical and biological attention because of their…”
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