Search Results - "Thérond, Pascal P"

Functions of Wnt and Hedgehog-containing extracellular vesicles in development and disease by Matusek, Tamás, Marcetteau, Julien, Thérond, Pascal P

“…Secreted morphogens play a major role in the intercellular communication necessary for animal development. It was initially thought that, in order to organize…”
Get full text

TMED10 mediates the loading of neosynthesised Sonic Hedgehog in COPII vesicles for efficient secretion and signalling by Bare, Yonis, Matusek, Tamás, Vriz, Sophie, Deffieu, Maika S., Thérond, Pascal P., Gaudin, Raphael

“…The morphogen Sonic Hedgehog (SHH) plays an important role in coordinating embryonic development. Short- and long-range SHH signalling occurs through a variety…”
Get full text

Hherisomes, Hedgehog specialized recycling endosomes, are required for high level Hedgehog signaling and tissue growth by Pizette, Sandrine, Matusek, Tamás, Herpers, Bram, Thérond, Pascal P., Rabouille, Catherine

“…In metazoans, tissue growth and patterning is partly controlled by the Hedgehog (Hh) morphogen. Using immuno-electron microscopy on Drosophila wing imaginal…”
Get full text

Release and transportation of Hedgehog molecules by Thérond, Pascal P

“…Highlights ► Lipidated Hedgehog proteins spread in the hydrophilic extracellular space. ► Different Hedgehog carriers are involved in short and long range…”
Get full text

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex by Ranieri, Nadia, Thérond, Pascal P., Ruel, Laurent

“…Hedgehog (Hh) signalling is crucial for developmental patterning and tissue homeostasis. In Drosophila , Hh signalling is mediated by a bifunctional…”
Get full text

The mechanisms of Hedgehog signalling and its roles in development and disease by Briscoe, James, Thérond, Pascal P.

“…Key Points The Hedgehog signalling pathway has diverse functions in animal development and tissue homeostasis. Dysregulation of the pathway has been implicated…”
Get full text

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli by Ruel, Laurent, Thérond, Pascal P

“…The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the…”
Get full text

The role of kinases in the Hedgehog signalling pathway by Aikin, Reid A, Ayers, Katie L, Thérond, Pascal P

“…The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila ,…”
Get full text

The ESCRT machinery regulates the secretion and long-range activity of Hedgehog by Matusek, Tamás, Wendler, Franz, Polès, Sophie, Pizette, Sandrine, D’Angelo, Gisela, Fürthauer, Maximilian, Thérond, Pascal P.

“…A new role for the endosomal sorting complex required for transport (ESCRT) is identified in fly larvae, where it is shown to be essential for the secretion…”
Get full text

Circulating Hedgehog: a fresh view of a classic morphogen by Prince, Elodie, Marcetteau, Julien, Thérond, Pascal P

“…Members of the Hedgehog family of morphogens mediate the intercellular communication necessary for the organisation and development of many animal tissues…”
Get full text

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis by Gallet, Armel, Staccini-Lavenant, Laurence, Thérond, Pascal P.

“…Hedgehog (Hh) and Wingless (Wg) morphogens specify cell fate in a concentration-dependent manner in the Drosophila wing imaginal disc. Proteoglycans,…”
Get full text

Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2 by Robbins, David J, Nybakken, Kent E, Kobayashi, Ryuji, Sisson, John C, Bishop, J.Michael, Thérond, Pascal P

“…The hedgehog gene of Drosophila melanogaster encodes a secreted protein (HH) that plays a vital role in cell fate and patterning. Here we describe a protein…”
Get full text

Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling by D’Angelo, Gisela, Matusek, Tamás, Pizette, Sandrine, Thérond, Pascal P.

“…The proteins of the Hedgehog (Hh) family are secreted proteins exerting short- and long-range control over various cell fates in developmental patterning. The…”
Get full text

Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development by Hurbain, Ilse, Macé, Anne-Sophie, Romao, Maryse, Prince, Elodie, Sengmanivong, Lucie, Ruel, Laurent, Basto, Renata, Thérond, Pascal P., Raposo, Graça, D’Angelo, Gisela

“…Morphogens are secreted molecules that regulate and coordinate major developmental processes, such as cell differentiation and tissue morphogenesis. Depending…”
Get full text

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling by Ayers, Katie L, Thérond, Pascal P

“…The Hedgehog signalling pathway controls numerous developmental processes. In response to Hedgehog, Smoothened (Smo), a seven-pass transmembrane protein,…”
Get full text

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum by Ayers, Katie L., Gallet, Armel, Staccini-Lavenant, Laurence, Thérond, Pascal P.

“…Cell fate determination during developmental patterning is often controlled by concentration gradients of morphogens. In the epithelial field, morphogens like…”
Get full text

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan by Rallis, Andrew, Navarro, Juan A., Rass, Mathias, Hu, Amélie, Birman, Serge, Schneuwly, Stephan, Thérond, Pascal P.

“…The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown. Here, we…”
Get full text

The GTPase Rab8 differentially controls the long- and short-range activity of the Hedgehog morphogen gradient by regulating Hedgehog apico-basal distribution by Gore, Tanvi, Matusek, Tamás, D'Angelo, Gisela, Giordano, Cécile, Tognacci, Thomas, Lavenant-Staccini, Laurence, Rabouille, Catherine, Thérond, Pascal P

“…The Hedgehog (Hh) morphogen gradient is required for patterning during metazoan development, yet the mechanisms involved in Hh apical and basolateral release…”
Get full text

Distinct Phosphorylations on Kinesin Costal-2 Mediate Differential Hedgehog Signaling Strength by Ranieri, Nadia, Ruel, Laurent, Gallet, Armel, Raisin, Sophie, Thérond, Pascal P.

“…The graded Hedgehog (Hh) signal is transduced by the transmembrane Smoothened (Smo) proteins in both vertebrates and invertebrates. In Drosophila, associations…”
Get full text

Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling by Ayers, Katie L, Mteirek, Rana, Cervantes, Alexandra, Lavenant-Staccini, Laurence, Thérond, Pascal P, Gallet, Armel

“…During development, secreted morphogens, such as Hedgehog (Hh), control cell fate and proliferation. Precise sensing of morphogen levels and dynamic cellular…”
Get full text