Search Results - "Tezera, Liku"

Reconsidering the Optimal Immune Response to Mycobacterium tuberculosis by Tezera, Liku B, Mansour, Salah, Elkington, Paul

“…Tezera et al discuss the need to reconsider the optimal immune response to mycobacterium tuberculosis. The worldwide death toll from tuberculosis is an ongoing…”
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The paradox of immune checkpoint inhibition re-activating tuberculosis by Ahmed, Mohamed, Tezera, Liku B., Elkington, Paul T., Leslie, Alasdair J.

“…By attenuating T-cell activation, immune checkpoints (ICs) limit optimal anti-tumour responses and IC inhibition (ICI) has emerged as a new therapy for a broad…”
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Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology by Brace, Patience T, Tezera, Liku B, Bielecka, Magdalena K, Mellows, Toby, Garay, Diana, Tian, Shuye, Rand, Lucinda, Green, Justin, Jogai, Sanjay, Steele, Andrew J, Millar, Timothy M, Sanchez-Elsner, Tilman, Friedland, Jon S, Proud, Christopher G, Elkington, Paul T

“…Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been…”
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Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis by Ugarte-Gil, Cesar A, Elkington, Paul, Gilman, Robert H, Coronel, Jorge, Tezera, Liku B, Bernabe-Ortiz, Antonio, Gotuzzo, Eduardo, Friedland, Jon S, Moore, David A J

“…Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship…”
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Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α by Tezera, Liku B, Bielecka, Magdalena K, Ogongo, Paul, Walker, Naomi F, Ellis, Matthew, Garay-Baquero, Diana J, Thomas, Kristian, Reichmann, Michaela T, Johnston, David A, Wilkinson, Katalin Andrea, Ahmed, Mohamed, Jogai, Sanjay, Jayasinghe, Suwan N, Wilkinson, Robert J, Mansour, Salah, Thomas, Gareth J, Ottensmeier, Christian H, Leslie, Alasdair, Elkington, Paul T

“…Previously, we developed a 3-dimensional cell culture model of human tuberculosis (TB) and demonstrated its potential to interrogate the host-pathogen…”
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Controlled Generation of Microspheres Incorporating Extracellular Matrix Fibrils for Three-Dimensional Cell Culture by Workman, Victoria L., Tezera, Liku B., Elkington, Paul T., Jayasinghe, Suwan N.

“…A growing body of evidence suggests that studying cell biology in classical two‐dimensional formats, such as cell culture plasticware, results in misleading,…”
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Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung by Ogongo, Paul, Tezera, Liku B, Ardain, Amanda, Nhamoyebonde, Shepherd, Ramsuran, Duran, Singh, Alveera, Ng'oepe, Abigail, Karim, Farina, Naidoo, Taryn, Khan, Khadija, Dullabh, Kaylesh J, Fehlings, Michael, Lee, Boon Heng, Nardin, Alessandra, Lindestam Arlehamn, Cecilia S, Sette, Alessandro, Behar, Samuel M, Steyn, Adrie Jc, Madansein, Rajhmun, Kløverpris, Henrik N, Elkington, Paul T, Leslie, Alasdair

“…T cell immunity is essential for the control of tuberculosis (TB), an important disease of the lung, and is generally studied in humans using peripheral blood…”
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Three-Dimensional Culture Modelling Reveals Divergent Mycobacterium tuberculosis Virulence and Antimicrobial Treatment Response by Bielecka, Magdalena K., Tezera, Liku B., Konstantinopoulou, Elena, Casali, Nicola, Katsamenis, Orestis L., Gonzalo, Ximena, Drobniewski, Francis, Elkington, Paul T.

“…Tuberculosis (TB) remains a persistent epidemic, and the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) presents a global healthcare threat…”
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Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets by Reichmann, Michaela T, Tezera, Liku B, Vallejo, Andres F, Vukmirovic, Milica, Xiao, Rui, Reynolds, James, Jogai, Sanjay, Wilson, Susan, Marshall, Ben, Jones, Mark G, Leslie, Alasdair, D'Armiento, Jeanine M, Kaminski, Naftali, Polak, Marta E, Elkington, Paul

“…Tuberculosis (TB) is a persistent global pandemic, and standard treatment for it has not changed for 30 years. Mycobacterium tuberculosis (Mtb) has undergone…”
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A Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis by Bielecka, Magdalena K, Tezera, Liku B, Zmijan, Robert, Drobniewski, Francis, Zhang, Xunli, Jayasinghe, Suwan, Elkington, Paul

“…Antimicrobial resistance presents one of the most significant threats to human health, with the emergence of totally drug-resistant organisms. We have combined…”
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Pericyte derived chemokines amplify neutrophil recruitment across the cerebrovascular endothelial barrier by Gil, Eliza, Venturini, Cristina, Stirling, David, Turner, Carolin, Tezera, Liku B, Ercoli, Giuseppe, Baker, Tina, Best, Katharine, Brown, Jeremy S, Noursadeghi, Mahdad

“…Excessive neutrophil extravasation can drive immunopathology, exemplified in pyogenic meningitis caused by infection. Insufficient knowledge of the mechanisms…”
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Matrix Degradation in Human Immunodeficiency Virus Type 1–Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study by Walker, Naomi F., Wilkinson, Katalin A., Meintjes, Graeme, Tezera, Liku B., Goliath, Rene, Peyper, Janique M., Tadokera, Rebecca, Opondo, Charles, Coussens, Anna K., Wilkinson, Robert J., Friedland, Jon S., Elkington, Paul T.

“…Background. Extensive immunopathology occurs in human immunodeficiency virus (HIV)/tuberculosis (TB) coinfection, but the underlying molecular mechanisms are…”
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Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model by Tezera, Liku B, Bielecka, Magdalena K, Chancellor, Andrew, Reichmann, Michaela T, Shammari, Basim Al, Brace, Patience, Batty, Alex, Tocheva, Annie, Jogai, Sanjay, Marshall, Ben G, Tebruegge, Marc, Jayasinghe, Suwan N, Mansour, Salah, Elkington, Paul T

“…Cell biology differs between traditional cell culture and 3-dimensional (3-D) systems, and is modulated by the extracellular matrix. Experimentation in 3-D…”
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Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis by Sathyamoorthy, Tarangini, Sandhu, Gurjinder, Tezera, Liku B, Thomas, Richard, Singhania, Akul, Woelk, Christopher H, Dimitrov, Borislav D, Agranoff, Dan, Evans, Carlton A W, Friedland, Jon S, Elkington, Paul T

“…Tuberculosis (TB) remains a global health pandemic and greater understanding of underlying pathogenesis is required to develop novel therapeutic and diagnostic…”
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Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model by Ahmed, Mohamed, Tezera, Liku B, Herbert, Nicholas, Chambers, Mark, Reichmann, Michaela T, Nargan, Kievershen, Kloverpris, Henrik, Karim, Farina, Hlatshwayo, Mbali, Madensein, Rajhmun, Habesh, Munir, Hoque, Monjural, Steyn, Adrie J C, Elkington, Paul T, Leslie, Alasdair J

“…A robust immune response is required for resistance to pulmonary tuberculosis (TB), the primary disease caused by ( ). However, pharmaceutical inhibition of T…”
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Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis by Ong, Catherine W M, Elkington, Paul T, Brilha, Sara, Ugarte-Gil, Cesar, Tome-Esteban, Maite T, Tezera, Liku B, Pabisiak, Przemyslaw J, Moores, Rachel C, Sathyamoorthy, Tarangini, Patel, Vimal, Gilman, Robert H, Porter, Joanna C, Friedland, Jon S

“…Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism…”
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Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis by Sathyamoorthy, Tarangini, Tezera, Liku B, Walker, Naomi F, Brilha, Sara, Saraiva, Luisa, Mauri, Francesco A, Wilkinson, Robert J, Friedland, Jon S, Elkington, Paul T

“…Tuberculosis (TB) remains a global pandemic and drug resistance is rising. Multicellular granuloma formation is the pathological hallmark of Mycobacterium…”
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Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis by Garay-Baquero, Diana J, White, Cory H, Walker, Naomi F, Tebruegge, Marc, Schiff, Hannah F, Ugarte-Gil, Cesar, Morris-Jones, Stephen, Marshall, Ben G, Manousopoulou, Antigoni, Adamson, John, Vallejo, Andres F, Bielecka, Magdalena K, Wilkinson, Robert J, Tezera, Liku B, Woelk, Christopher H, Garbis, Spiros D, Elkington, Paul

“…BACKGROUNDTuberculosis (TB) kills more people than any other infection, and new diagnostic tests to identify active cases are required. We aimed to discover…”
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Anti-Tuberculosis Activity of Three Carbapenems, Clofazimine and Nitazoxanide Using a Novel Ex Vivo Phenotypic Drug Susceptibility Model of Human Tuberculosis by Gonzalo, Ximena, Bielecka, Magdalena K, Tezera, Liku, Elkington, Paul, Drobniewski, Francis

“…We evaluated a novel physiological 3-D bioelectrospray model of the tuberculosis (TB) granuloma to test the activity of a known anti-TB drug, clofazimine;…”
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Bioelectrospray Methodology for Dissection of the Host-pathogen Interaction in Human Tuberculosis by Tezera, Liku B, Bielecka, Magdalena K, Elkington, Paul T

“…Standard cell culture models have been used to investigate disease pathology and to test new therapies for over fifty years. However, these model systems have…”
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