Search Results - "Tezel, Gulgun"

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets by Tezel, Gülgün

“…Neuroinflammation relying on the inflammatory responses of glial cells has emerged as an impactful component of the multifactorial etiology of…”
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Oxidative stress in glaucomatous neurodegeneration: Mechanisms and consequences by Tezel, Gülgün

“…Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. Although ROS are essential participants in…”
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Multiplex protein analysis for the study of glaucoma by Tezel, Gülgün

“…Glaucoma, a leading cause of irreversible blindness in the world, is a chronic neurodegenerative disease of multifactorial origin. Extensive research is…”
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Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects by Tezel, Gülgün

“…Glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cell (RGC) somas, degeneration of axons, and loss of synapses at…”
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Antioxidant Treatment Limits Neuroinflammation in Experimental Glaucoma by Yang, Xiangjun, Hondur, Gözde, Tezel, Gülgün

“…Besides primary neurotoxicity, oxidative stress may compromise the glial immune regulation and shift the immune homeostasis toward neurodegenerative…”
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Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma by Yang, Xiangjun, Zeng, Qun, Tezel, Gülgün

“…Retinal ganglion cells (RGCs) expanding from the retina to the brain are primary victims of neurodegeneration in glaucoma, a leading cause of blindness;…”
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Neville Osborne - Editor-in-Chief of Progress in Retinal and Eye Research for 40 years by Schmetterer, Leopold, Tezel, Gülgün, Schuman, Joel

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Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma by Yang, Xiangjun, Zeng, Qun, Barış, Mine, Tezel, Gülgün

“…Glia-driven neuroinflammation promotes neuron injury in glaucoma that is a chronic neurodegenerative disease of the optic nerve and a leading cause of…”
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cFLIP in the molecular regulation of astroglia-driven neuroinflammation in experimental glaucoma by Yang, Xiangjun, Zeng, Qun, İnam, Maide Gözde, İnam, Onur, Lin, Chyuan-Sheng, Tezel, Gülgün

“…Recent experimental studies of neuroinflammation in glaucoma pointed to cFLIP as a molecular switch for cell fate decisions, mainly regulating cell…”
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T-Lymphocyte Subset Distribution and Activity in Patients With Glaucoma by Yang, Xiangjun, Zeng, Qun, Göktas, Emre, Gopal, Kalashree, Al-Aswad, Lama, Blumberg, Dana M, Cioffi, George A, Liebmann, Jeffrey M, Tezel, Gülgün

“…Besides glia-driven neuroinflammation, growing evidence from analysis of human blood samples, isolated autoantibodies, and postmortem tissues also support…”
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Early localized alterations of the retinal inner plexiform layer in association with visual field worsening in glaucoma patients by Aydın, Rukiye, Barış, Mine, Durmaz-Engin, Ceren, Al-Aswad, Lama A, Blumberg, Dana M, Cioffi, George A, Liebmann, Jeffrey M, Tezel, Tongalp H, Tezel, Gülgün

“…Glaucoma is a chronic neurodegenerative disease of the optic nerve and a leading cause of irreversible blindness, worldwide. While the experimental research…”
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High-Frequency Ultrasound Activation of Perfluorocarbon Nanodroplets for Treatment of Glaucoma by Silverman, Ronald H., Urs, Raksha, Burgess, Mark, Ketterling, Jeffrey A., Tezel, Gulgun

“…Elevated intraocular pressure (IOP) is the most prevalent risk factor for initiation and progression of neurodegeneration in glaucoma. Ocular hypertension…”
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Immunomodulation as a Neuroprotective Strategy for Glaucoma Treatment by Barış, Mine, Tezel, Gülgün

“…Purpose of Review This review aims to highlight the current knowledge about inflammatory mechanisms of neurodegeneration in glaucoma with emphasis on potential…”
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Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cell Neurons via Activated T-Cell-Derived Fas-Ligand by Wax, Martin B, Tezel, Gulgun, Yang, Junjie, Peng, Guanghua, Patil, Rajkumar V, Agarwal, Neeraj, Sappington, Rebecca M, Calkins, David J

“…Glaucomatous optic neuropathy causes blindness through the degeneration of retinal ganglion cells (RGCs) and their axons, which comprise the optic nerve…”
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A decade of proteomics studies of glaucomatous neurodegeneration by Tezel, Gülgün

“…Glaucoma is a leading cause of blindness; however, limited understanding of the molecular mechanisms involved in optic nerve degeneration hinders the…”
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Oxidative Stress-Related Molecular Biomarker Candidates for Glaucoma by Hondur, Gözde, Göktas, Emre, Yang, Xiangjun, Al-Aswad, Lama, Auran, James D, Blumberg, Dana M, Cioffi, George A, Liebmann, Jeffrey M, Suh, Leejee H, Trief, Danielle, Tezel, Gülgün

“…Glaucoma-related molecular biomarkers can improve clinical testing to diagnose the disease early, predict its prognosis, and monitor treatment responses. Based…”
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Accelerated Aging in Glaucoma: Immunohistochemical Assessment of Advanced Glycation End Products in the Human Retina and Optic Nerve Head by Tezel, Gulgun, Luo, Cheng, Yang, Xiangjun

“…This study aimed to determine the association between advanced glycation end products (AGEs) and glaucoma based on the known synergism between oxidative stress…”
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Proteomic Identification of Oxidatively Modified Retinal Proteins in a Chronic Pressure-Induced Rat Model of Glaucoma by Tezel, Gulgun, Yang, Xiangjun, Cai, Jian

“…Based on the evidence of an amplified production of reactive oxygen species (ROS) during glaucomatous neurodegeneration, proteomic analysis was performed to…”
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Scleral fibroblast response to experimental glaucoma in mice by Oglesby, Ericka N, Tezel, Gülgün, Cone-Kimball, Elizabeth, Steinhart, Matthew R, Jefferys, Joan, Pease, Mary E, Quigley, Harry A

“…To study the detailed cellular and molecular changes in the mouse sclera subjected to experimental glaucoma. Three strains of mice underwent experimental…”
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Mechanisms of Immune System Activation in Glaucoma: Oxidative Stress-Stimulated Antigen Presentation by the Retina and Optic Nerve Head Glia by Tezel, Gulgun, Yang, Xiangjun, Luo, Cheng, Peng, Yong, Sun, Sheher L, Sun, Deming

“…Evidence supports the immune system activity accompanying glaucomatous neurodegeneration. This study aimed to determine the in vitro effects of reactive oxygen…”
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