Search Results - "Tewes, Frederic"

Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones by Brillault, Julien, Tewes, Frédéric

“…Pulmonary drug delivery is a promising strategy to treat lung infectious disease as it allows for a high local drug concentration and low systemic side…”
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(E, E)-farnesol and myristic acid-loaded lipid nanoparticles overcome colistin resistance in Acinetobacter baumannii by Faivre, Carla, Imtiyaz, Farras Daffa, Buyck, Julien M., Marchand, Sandrine, Marcotte, Melissa, Henry, Thomas, Anton, Nicolas, Collot, Mayeul, Tewes, Frédéric

“…[Display omitted] The rise of colistin-resistant Acinetobacter baumannii has severely limited treatment options for infections caused by this pathogen. While…”
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Sustained-release microparticle dry powders of chloramphenicol palmitate or thiamphenicol palmitate prodrugs for lung delivery as aerosols by Nurbaeti, Siti Nani, Brillault, Julien, Tewes, Frédéric, Olivier, Jean-Christophe

“…The purpose of this study was to design inhalable sustained-release nanoparticle-in-microparticles, i.e. nano-embedded microparticles, for the lung delivery of…”
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Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery by Tewes, Frederic, Gobbo, Oliviero L, Ehrhardt, Carsten, Healy, Anne Marie

“…Amorphous calcium carbonate (ACC) is known to interact with proteins, for example, in biogenic ACC, to form stable amorphous phases. The control of…”
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In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable? by Torres, Bruna Gaelzer Silva, Awad, Rana, Marchand, Sandrine, Couet, William, Tewes, Frederic

“…[Display omitted] Animal models of chronic lung infection with P. aeruginosa (PA) are useful tools to improve antibiotic (ATB) treatment. Two main models based…”
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Assessment of inhaled cationic antibiotics in an in vitro model of Pseudomonas aeruginosa lung biofilm by Awad, Rana, Marchand, Sandrine, Couet, William, Nasser, Mohamad, Buyck, Julien M., Tewes, Frédéric

“…This study aimed to evaluate the efficacy of inhaled cationic antibiotics, including tobramycin (TOB) and colistin (CST), using an in vitro alginate bead model…”
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Impact of mixed Staphylococcus aureus-Pseudomonas aeruginosa biofilm on susceptibility to antimicrobial treatments in a 3D in vitro model by Landa, Guillermo, Clarhaut, Jonathan, Buyck, Julien, Mendoza, Gracia, Arruebo, Manuel, Tewes, Frederic

“…Staphylococcus aureus and Pseudomonas aeruginosa are the most common bacteria co-isolated from chronic infected wounds. Their interactions remain unclear but…”
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Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections by Brunet, Kévin, Martellosio, Jean-Philippe, Tewes, Frédéric, Marchand, Sandrine, Rammaert, Blandine

“…Pulmonary mold infections are life-threatening diseases with high morbi-mortalities. Treatment is based on systemic antifungal agents belonging to the families…”
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New aerosol formulation to control ciprofloxacin pulmonary concentration by Lamy, Barbara, Tewes, Frederic, Serrano, Dolores Remedios, Lamarche, Isabelle, Gobin, Patrice, Couet, William, Healy, Anne Marie, Marchand, Sandrine

“…Ciprofloxacin (CIP) apparent permeability across a pulmonary epithelium model can be controlled by the affinity of its complex with a metal cation. The higher…”
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Moisture diffusion and permeability characteristics of hydroxypropylmethylcellulose and hard gelatin capsules by Barham, Ahmad S., Tewes, Frederic, Healy, Anne Marie

“…[Display omitted] The primary objective of this paper is to compare the sorption characteristics of hydroxypropylmethylcellulose (HPMC) and hard gelatin (HG)…”
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Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation by Amaro, Maria Inês, Tewes, Frederic, Gobbo, Oliviero, Tajber, Lidia, Corrigan, Owen I., Ehrhardt, Carsten, Healy, Anne Marie

“…[Display omitted] A challenge exists to produce dry powder inhaler (DPI) formulations with appropriate formulation stability, biological activity and suitable…”
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Lipid Nanoparticles Loaded with Farnesol or Geraniol to Enhance the Susceptibility of E. coli MCR-1 to Colistin by Valcourt, Chantal, Buyck, Julien M., Grégoire, Nicolas, Couet, William, Marchand, Sandrine, Tewes, Frédéric

“…Resistance to colistin, one of the antibiotics of last resort against multidrug-resistant Gram-negative bacteria, is increasingly reported. Notably, MCR…”
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In vivo efficacy of a dry powder formulation of ciprofloxacin-copper complex in a chronic lung infection model of bioluminescent Pseudomonas aeruginosa by Tewes, Frédéric, Bahamondez-Canas, Tania F., Moraga-Espinoza, Daniel, Smyth, Hugh D.C., Watts, Alan B.

“…[Display omitted] A significant limitation of locally delivered treatments for chronic pulmonary infections is often the short residence time within the…”
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PK-PD Evaluation of Inhaled Microparticles loaded with Ciprofloxacin-Copper complex in a Rat Model of Chronic Pseudomonas aeruginosa Lung Infection by Tewes, Frederic, Lamy, Barbara, Laroche, Julian, Lamarche, Isabelle, Marchand, Sandrine

“…The potential gain in efficacy of pulmonary administration over IV administration of some antibiotics such as ciprofloxacin (CIP) may be limited by the short…”
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Optimization of levofloxacin-loaded crosslinked chitosan microspheres for inhaled aerosol therapy by Gaspar, Marisa C., Sousa, João J.S., Pais, Alberto A.C.C., Cardoso, Olga, Murtinho, Dina, Serra, M. Elisa S., Tewes, Frédéric, Olivier, Jean-Christophe

“…[Display omitted] The aim of this work was the development of innovative levofloxacin-loaded swellable microspheres (MS) for the dry aerosol therapy of…”
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Pan‐azole‐resistant Meyerozyma guilliermondii clonal isolates harbouring a double F126L and L505F mutation in Erg11 by Moreau, Jérémy, Noël, Thierry, Point, Kévin, Tewes, Frédéric, Deroche, Luc, Clarhaut, Jonathan, Fitton‐Ouhabi, Valérie, Perraud, Estelle, Marchand, Sandrine, Buyck, Julien M., Brunet, Kévin

“…Background Meyerozyma guilliermondii is a yeast species responsible for invasive fungal infections. It has high minimum inhibitory concentrations (MICs) to…”
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Efficacy of Ciprofloxacin and Its Copper Complex against Pseudomonas aeruginosa Biofilms by Tewes, Frederic, Bahamondez-Canas, Tania F., Smyth, Hugh D. C.

“…A limitation of antibiotic treatments for P. aeruginosa (PA) chronic pulmonary infections is the reduced efficacy due to sub-therapeutic concentrations at the…”
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Formulation of rifampicin–cyclodextrin complexes for lung nebulization by Tewes, Frédéric, Brillault, Julien, Couet, William, Olivier, Jean-Christophe

“…Lung administration of antibiotics by nebulization is promising for improving treatment efficiency for pulmonary infections, as it increases drug concentration…”
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Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery by Tewes, Frédéric, Brillault, Julien, Gregoire, Nicolas, Olivier, Jean-Christophe, Lamarche, Isabelle, Adier, Christophe, Healy, Anne-Marie, Marchand, Sandrine

“…To assess the difference in the fate of the antibiotic colistin (COLI) after its pulmonary delivery as a powder or a solution, we developed a COLI powder and…”
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Improved In Vitro Anti- Mucorales Activity and Cytotoxicity of Amphotericin B with a Pegylated Surfactant by Brunet, Kévin, Diop, Cheikh A B, Chauzy, Alexia, Prébonnaud, Noémie, Marchand, Sandrine, Rammaert, Blandine, Tewes, Frédéric

“…The aim of this study was to evaluate the effect of the combination of amphotericin B (AmB) and various non-ionic surfactants on the anti- activity of AmB, the…”
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