Search Results - "Tewari, Ritika"

Regulation of T cell receptor signaling by protein acyltransferase DHHC21 by Fan, Ying, Shayahati, Bieerkehazhi, Tewari, Ritika, Boehning, Darren, Akimzhanov, Askar M.

“…S-acylation reversible—post-translational lipidation of cysteine residues—is emerging as an important regulatory mechanism in T cell signaling. Dynamic…”
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T cell receptor–dependent S-acylation of ZAP-70 controls activation of T cells by Tewari, Ritika, Shayahati, Bieerkehazhi, Fan, Ying, Akimzhanov, Askar M.

“…ZAP-70 is a tyrosine kinase essential for T cell immune responses. Upon engagement of the T cell receptor (TCR), ZAP-70 is recruited to the specialized plasma…”
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Induced oligomerization targets Golgi proteins for degradation in lysosomes by Tewari, Ritika, Bachert, Collin, Linstedt, Adam D

“…Manganese protects cells against forms of Shiga toxin by down-regulating the cycling Golgi protein GPP130. Down-regulation occurs when Mn binding causes GPP130…”
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Dynamic S-acylation of the ER-resident protein stromal interaction molecule 1 (STIM1) is required for store-operated Ca2+ entry by Kodkandla, Goutham, West, Savannah J., Wang, Qiaochu, Tewari, Ritika, Zhu, Michael X., Akimzhanov, Askar M., Boehning, Darren

“…Many cell surface stimuli cause calcium release from endoplasmic reticulum (ER) stores to regulate cellular physiology. Upon ER calcium store depletion, the…”
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S-acylation of Orai1 regulates store-operated Ca2+ entry by West, Savannah J., Kodakandla, Goutham, Wang, Qioachu, Tewari, Ritika, Zhu, Michael X., Boehning, Darren, Akimzhanov, Askar M.

“…Store-operated Ca2+ entry is a central component of intracellular Ca2+ signaling pathways. The Ca2+ release-activated channel (CRAC) mediates store-operated…”
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The Paris Agreement: resolving the inconsistency between global goals and national contributions by Höhne, Niklas, Kuramochi, Takeshi, Warnecke, Carsten, Röser, Frauke, Fekete, Hanna, Hagemann, Markus, Day, Thomas, Tewari, Ritika, Kurdziel, Marie, Sterl, Sebastian, Gonzales, Sofia

“…The adoption of the Paris Agreement in December 2015 moved the world a step closer to avoiding dangerous climate change. The aggregated individual intended…”
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S‐acylation of STIM1 regulates store‐operated calcium entry by Kodakandla, Goutham, West, Savannah, Wang, Qioachu, Tewari, Ritika, Zhu, Michael, Akimzhanov, Askar, Boehning, Darren F.

“…The initiating events happening during store‐operated calcium entry are not completely understood despite the tremendous importance of this process in immune…”
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Ca2+-dependent protein acyltransferase DHHC21 controls activation of CD4+ T cells by Bieerkehazhi, Shayahati, Fan, Ying, West, Savannah J, Tewari, Ritika, Ko, Junsuk, Mills, Tingting, Boehning, Darren, Akimzhanov, Askar M

“…Despite the recognized significance of reversible protein lipidation (S-acylation) for T cell receptor signal transduction, the enzymatic control of this…”
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S-Acylation regulates store-operated calcium entry by West, Savannah J., Kodakandla, Goutham, Wang, Qiaochu, Tewari, Ritika, Zhu, Michael X., Boehning, Darren, Akimzhanov, Askar M.

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Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin by Tewari, Ritika, Jarvela, Timothy, Linstedt, Adam D

“…Manganese (Mn) protects cells against lethal doses of purified Shiga toxin by causing the degradation of the cycling transmembrane protein GPP130, which the…”
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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture by Tewari, Ritika, West, Savannah J, Shayahati, Bieerkehazi, Akimzhanov, Askar M

“…Protein S-acylation, also referred to as S-palmitoylation, is a reversible post-translational modification of cysteine residues with long-chain fatty acids via…”
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The ubiquitin ligase UBE4B regulates amyloid precursor protein ubiquitination, endosomal trafficking, and amyloid β42 generation and secretion by Gireud-Goss, Monica, Reyes, Sahily, Tewari, Ritika, Patrizz, Anthony, Howe, Matthew D., Kofler, Julia, Waxham, M. Neal, McCullough, Louise D., Bean, Andrew J.

“…The extracellular accumulation of amyloid β (Aβ) fragments of amyloid precursor protein (APP) in brain parenchyma is a pathological hallmark of Alzheimer's…”
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Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy by Tewari, Ritika, Yang, Soo Jung, McClain, Ethan D., Hu, Alex, Mortensen, Emma, DeSchmidt, Aleah, Chen, Janice, Kancharla, Aravind, Singh, Akhilesh K., James, Eddie A., Burman, Blaire E., Siddique, Asma, Rawlings, David J., Patel, Chandra, Cerosaletti, Karen, Buckner, Jane H.

“…Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease, characterized by progressive destruction of small intrahepatic bile ducts and portal…”
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GNTI-122: an autologous antigen-specific engineered Treg cell therapy for type 1 diabetes by Uenishi, Gene I, Repic, Marko, Yam, Jennifer Y, Landuyt, Ashley, Saikumar-Lakshmi, Priya, Guo, Tingxi, Zarin, Payam, Sassone-Corsi, Martina, Chicoine, Adam, Kellogg, Hunter, Hunt, Martina, Drow, Travis, Tewari, Ritika, Cook, Peter J, Yang, Soo Jung, Cerosaletti, Karen, Schweinoch, Darius, Guiastrennec, Benjamin, James, Eddie, Patel, Chandra, Chen, Tiffany F, Buckner, Jane H, Rawlings, David J, Wickham, Thomas J, Mueller, Karen T

“…Tregs have the potential to establish long-term immune tolerance in patients recently diagnosed with type 1 diabetes (T1D) by preserving β cell function…”
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Examining the Developments in the International Registry for NAMAs and Channels of Support by Tewari, Ritika

“…Conceptually, nationally appropriate mitigation actions (NAMAs) provided a framework for mitigation in developing countries. Since COP 13 in Bali, discussions…”
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