Search Results - "Tew, K.D"

Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation by Manevich, Y., Hutchens, S., Tew, K.D., Townsend, D.M.

“…The dual-functioning antioxidant enzyme peroxiredoxin VI (Prdx6) detoxifies lipid peroxides particularly in biological membranes, and its peroxidase function…”
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The role of carotenoids in the prevention of human pathologies by Tapiero, H, Townsend, D.M, Tew, K.D

“…Reactive oxygen species (ROS) and oxidative damage to biomolecules have been postulated to be involved in the causation and progression of several chronic…”
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Trace elements in human physiology and pathology. Copper by Tapiero, H., Townsend, D.M., Tew, K.D.

“…Copper is a trace element, important for the function of many cellular enzymes. Copper ions can adopt distinct redox states oxidized Cu(II) or reduced (I),…”
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The antioxidant role of selenium and seleno-compounds by Tapiero, H, Townsend, D.M, Tew, K.D

“…Selenium (Se) is an essential trace element for animals and humans that is obtained from dietary sources including cereals, grains and vegetables. The Se…”
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Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies by Tapiero, H, Nguyen Ba, G, Couvreur, P, Tew, K.D

“…Linoleic and alpha-linolenic acids, obtained from plant material in the diet are the precursors in tissues of two families with opposing effects which are…”
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Oxidative stress induced in pathologies: The role of antioxidants by Gaté, L., Paul, J., Ba, G. Nguyen, Tew, K.D., Tapiero, H.

“…Exposure to oxidant molecules issued from the environment (pollution, radiation), nutrition, or pathologies can generate reactive oxygen species (ROS for…”
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Phytosterols in the prevention of human pathologies by Tapiero, H., Townsend, D.M., Tew, K.D.

“…Coronary heart disease is a major health problem in developed countries. Many studies have shown that elevated serum concentrations of total or…”
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Glutathione and related enzymes in multidrug resistance by O'Brien, M.L., Tew, K.D.

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Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic by Uys, J.D, Manevich, Y, DeVane, L.C, He, L, Garret, T.E, Pazoles, C.J, Tew, K.D, Townsend, D.M

“…Abstract NOV-002 is a glutathione disulfide (GSSG) mimetic that is the subject of clinical investigation in oncology indications. GSSG is reduced by…”
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Cloning and characterization of human colon glyoxalase-I by SULABHA RANGANATHAN, WALSH, E. S, GODWIN, A. K, TEW, K. D

“…Glyoxalase-I cDNA clones were isolated from a human colon cDNA library using polyclonal antibodies raised against the protein purified from human colon tissue…”
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Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation by Bartolini, D., Piroddi, M., Tidei, C., Giovagnoli, S., Pietrella, D., Manevich, Y., Tew, K.D., Giustarini, D., Rossi, R., Townsend, D.M., Santi, C., Galli, F.

“…Catalytic properties and cellular effects of the glutathione peroxidase (GPx)-mimetic compound PhSeZnCl or its d,l-lactide polymer microencapsulation form…”
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Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome by Manevich, Y., Hutchens, S., Halushka, P.V., Tew, K.D., Townsend, D.M., Jauch, E.C., Borg, K.

“…Traumatic brain injury (TBI) patients would benefit from the identification of reliable biomarkers to predict outcomes and treatment strategies. In our study,…”
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Allelic Variants of GSTP Specifically Regulate a Prdx6-mediated Protection of Membrane Against Lipid Peroxidation by Manevich⁎, Y., Hutchens, S., Townsend, D., Tew, K.D.

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Polyphenols: do they play a role in the prevention of human pathologies? by Tapiero, H, Tew, K.D, Nguyen Ba, G, Mathé, G

“…Polyphenols are the most abundant antioxidants in our diets. The main classes of polyphenols are phenolic acids (mainly caffeic acid) and flavonoids (the most…”
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Peroxiredoxin VI Oxidation in Cerebrospinal Fluid Correlates with TBI Outcome by Manevich, Y., Hutchens, S., Halushka, P.V., Tew, K.D., Townsend, D. M., Jauch, E.C., Borg, K.

“…Traumatic brain injury (TBI) patients would benefit from the identification of reliable biomarkers to predict outcomes and treatment strategies. In our study,…”
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II. Glutamine and glutamate by Tapiero, H, Mathé, G, Couvreur, P, Tew, K.D

“…Glutamine and glutamate with proline, histidine, arginine and ornithine, comprise 25% of the dietary amino acid intake and constitute the “glutamate family” of…”
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I. Arginine by Tapiero, H, Mathé, G, Couvreur, P, Tew, K.D

“…L-Arginine (Arg) is classified as an essential amino acid for birds, carnivores and young mammals and a conditionally essential amino acid for adults. It is…”
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Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response by Lei, K, Townsend, D M, Tew, K D

“…Sulfiredoxin (Srx) is one of a family of low molecular weight sulfur containing proteins linked with maintenance of cellular redox balance. One function of Srx…”
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Estrogens and environmental estrogens by Tapiero, H, Nguyen Ba, G, Tew, K.D

“…The natural female sex hormone estrogens binds once inside the cell to a protein receptor to form a ‘ligand-hormone receptor complex’. The binding activates…”
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Iron: deficiencies and requirements by Tapiero, H, Gaté, L, Tew, K.D

“…A report from the World Health Organization estimates that 46% of the world’s 5- to 14-year-old children are anemic. In addition, 48% of the world’s pregnant…”
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