Search Results - "Tew, Gaik W"

Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial by Vermeire, Séverine, Dr, O'Byrne, Sharon, MD, Keir, Mary, PhD, Williams, Marna, PhD, Lu, Timothy T, MD, Mansfield, John C, MD, Lamb, Christopher A, MD, Feagan, Brian G, MD, Panes, Julian, MD, Salas, Azucena, PhD, Baumgart, Daniel C, MD, Schreiber, Stefan, MD, Dotan, Iris, MD, Sandborn, William J, MD, Tew, Gaik W, MSc, Luca, Diana, PhD, Tang, Meina T, PhD, Diehl, Lauri, DVM, Eastham-Anderson, Jeffrey, MS, De Hertogh, Gert, MD, Perrier, Clementine, PhD, Egen, Jackson G, PhD, Kirby, John A, PhD, van Assche, Gert, MD, Rutgeerts, Paul, MD

“…Summary Background Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed…”
Get full text

Bioactive lipid lysophosphatidic acid species are associated with disease progression in idiopathic pulmonary fibrosis by Neighbors, Margaret, Li, Qingling, Zhu, Sha (Joe), Liu, Jia, Wong, Weng Ruh, Jia, Guiquan, Sandoval, Wendy, Tew, Gaik W.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive disease with significant mortality. Prognostic biomarkers to identify rapid progressors are urgently…”
Get full text

Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease by Li, Qingling, Wong, Weng, Birnberg, Andrew, Chakrabarti, Arindam, Yang, Xiaoying, Choy, David F, Olsson, Julie, Verschueren, Erik, Neighbors, Margaret, Sandoval, Wendy, Rosenberger, Carrie M, Grimbaldeston, Michele A, Tew, Gaik W

“…Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid…”
Get full text

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis by Chakrabarti, Arindam, Mar, Jordan S., Choy, David F., Cao, Yi, Rathore, Nisha, Yang, Xiaoying, Tew, Gaik W., Li, Olga, Woodruff, Prescott G., Brightling, Christopher E., Grimbaldeston, Michele, Christenson, Stephanie A., Bafadhel, Mona, Rosenberger, Carrie M.

“…Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in…”
Get full text

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights? by Ditz, Benedikt, Boekhoudt, Jeunard G, Aliee, Hananeh, Theis, Fabian J, Nawijn, Martijn, Brandsma, Corry-Anke, Hiemstra, Pieter S, Timens, Wim, Tew, Gaik W, Grimbaldeston, Michele A, Neighbors, Margaret, Guryev, Victor, van den Berge, Maarten, Faiz, Alen

“…https://bit.ly/2N8sY3s…”
Get full text

Fc receptor-like 5 and anti-CD20 treatment response in granulomatosis with polyangiitis and microscopic polyangiitis by Owczarczyk, Kasia, Cascino, Matthew D, Holweg, Cecile, Tew, Gaik W, Ortmann, Ward, Behrens, Timothy, Schindler, Thomas, Langford, Carol A, St Clair, E William, Merkel, Peter A, Spiera, Robert, Seo, Philip, Kallenberg, Cees Gm, Specks, Ulrich, Lim, Noha, Stone, John, Brunetta, Paul, Prunotto, Marco

“…BACKGROUNDBaseline expression of FCRL5, a marker of naive and memory B cells, was shown to predict response to rituximab (RTX) in rheumatoid arthritis. This…”
Get full text

Association Between Response to Etrolizumab and Expression of Integrin αE and Granzyme A in Colon Biopsies of Patients With Ulcerative Colitis by Tew, Gaik W, Hackney, Jason A, Gibbons, Deena, Lamb, Christopher A, Luca, Diana, Egen, Jackson G, Diehl, Lauri, Eastham Anderson, Jeff, Vermeire, Severine, Mansfield, John C, Feagan, Brian G, Panes, Julian, Baumgart, Daniel C, Schreiber, Stefan, Dotan, Iris, Sandborn, William J, Kirby, John A, Irving, Peter M, De Hertogh, Gert, Van Assche, Gert A, Rutgeerts, Paul, O’Byrne, Sharon, Hayday, Adrian, Keir, Mary E

“…Background & Aims Etrolizumab is a humanized monoclonal antibody against the β7 integrin subunit that has shown efficacy vs placebo in patients with moderate…”
Get full text

Prognostic and predictive biomarkers for patients with idiopathic pulmonary fibrosis treated with pirfenidone: post-hoc assessment of the CAPACITY and ASCEND trials by Neighbors, Margaret, Cabanski, Christopher R, Ramalingam, Thirumalai R, Sheng, X Rebecca, Tew, Gaik W, Gu, Chunyan, Jia, Guiquan, Peng, Kun, Ray, Jill M, Ley, Brett, Wolters, Paul J, Collard, Harold R, Arron, Joseph R

“…Heterogeneity in the progression of idiopathic pulmonary fibrosis (IPF) might reflect diversity in underlying pathobiology, and represents a major challenge in…”
Get full text

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD by Tasena, Hataitip, Faiz, Alen, Timens, Wim, Noordhoek, Jacobien, Hylkema, Machteld N, Gosens, Reinoud, Hiemstra, Pieter S, Spira, Avrum, Postma, Dirkje S, Tew, Gaik W, Grimbaldeston, Michele A, van den Berge, Maarten, Heijink, Irene H, Brandsma, Corry-Anke

“…Chronic mucus hypersecretion (CMH) is a common feature in chronic obstructive pulmonary disease (COPD) and is associated with worse prognosis and quality of…”
Get full text

Serum Lysophosphatidic Acid Measurement by Liquid Chromatography–Mass Spectrometry in COPD Patients by Li, Qingling, Wong, Weng R, Chakrabarti, Arindam, Birnberg, Andrew, Yang, Xiaoying, Verschueren, Erik, Neighbors, Margaret, Rosenberger, Carrie, Grimbaldeston, Michele, Tew, Gaik W, Sandoval, Wendy

“…Lysophospholipids are bioactive signaling molecules derived from cell membrane glycerophospholipids or sphingolipids and are highly regulated under normal…”
Get full text

RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD by Allam, Venkata Sita Rama Raju, Faiz, Alen, Lam, Maggie, Rathnayake, Senani N. H., Ditz, Benedikt, Pouwels, Simon D., Brandsma, Corry‐Anke, Timens, Wim, Hiemstra, Pieter S., Tew, Gaik W., Neighbors, Margaret, Grimbaldeston, Michele, van den Berge, Maarten, Donnelly, Sheila, Phipps, Simon, Bourke, Jane E., Sukkar, Maria B.

“…Background The receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4) is implicated in COPD. Although these receptors share common…”
Get full text

αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis by Lamb, Christopher A, Mansfield, John C, Tew, Gaik W, Gibbons, Deena, Long, Anna K, Irving, Peter, Diehl, Lauri, Eastham-Anderson, Jeff, Price, Maria B, O'Boyle, Graeme, Jones, David E J, O'Byrne, Sharon, Hayday, Adrian, Keir, Mary E, Egen, Jackson G, Kirby, John A

“…The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of…”
Get full text

αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis by Lamb, Christopher A, Mansfield, John C, Tew, Gaik W, Gibbons, Deena, Long, Anna K, Irving, Peter, Diehl, Lauri, Eastham-Anderson, Jeff, Price, Maria B, O'Boyle, Graeme, Jones, David E J, O'Byrne, Sharon, Hayday, Adrian, Keir, Mary E, Egen, Jackson G, Kirby, John A

“…The αEβ7 integrin is crucial for retention of T lymphocytes at mucosal surfaces through its interaction with E-cadherin. Pathogenic or protective functions of…”
Get full text

Sa1241 Pharmacology of Etrolizumab in a Phase 2 Study in Moderate-to-Severely Active Ulcerative Colitis by Looney, Caroline, Fuh, Franklin, Tang, Meina T, Wei, Xiaohui, Keir, Mary E, Tew, Gaik W, Eastham-Anderson, Jeffrey, Diehl, Lauri, Salas, Azucena, De Hertogh, Gert, Francom, Steven, Gilbert, Houston, Luca, Diana, Egen, Jackson G, Vermeire, Severine, Mansfield, John C, Lamb, Christopher A, Feagan, Brian G, Panes, Julian, Baumgart, Daniel C, Schreiber, Stefan, Dotan, Iris, Sandborn, William, Rutgeerts, Paul J, Lu, Timothy, O'Byrne, Sharon, Williams, Marna

Get full text

Reply by Keir, Mary E., Tew, Gaik W., Hackney, Jason A.

Get full text

Reply by Keir, Mary E, Tew, Gaik W, Hackney, Jason A

Get full text

Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways by Aliee, Hananeh, Massip, Florian, Qi, Cancan, Stella de Biase, Maria, Nijnatten, Jos, Kersten, Elin T. G., Kermani, Nazanin Z., Khuder, Basil, Vonk, Judith M., Vermeulen, Roel C. H., Neighbors, Margaret, Tew, Gaik W., Grimbaldeston, Michele A., Hacken, Nick H. T., Hu, Sile, Guo, Yike, Zhang, Xiaoyu, Sun, Kai, Hiemstra, Pieter S., Ponder, Bruce A., Mäkelä, Mika J., Malmström, Kristiina, Rintoul, Robert C, Reyfman, Paul A., Theis, Fabian J., Brandsma, Corry‐Anke, Adcock, Ian M., Timens, Wim, Xu, Cheng‐Jian, Berge, Maarten, Schwarz, Roland F., Koppelman, Gerard H., Nawijn, M.C., Faiz, Alen

Get full text

Reply by Keir, Mary E, Tew, Gaik W, Hackney, Jason A

Get full text

Reply by Keir, Mary E, Tew, Gaik W, Hackney, Jason A

Get full text

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response by Slob, Elise M. A., Faiz, Alen, Nijnatten, Jos, Vijverberg, Susanne J. H., Longo, Cristina, Kutlu, Merve, Chew, Fook Tim, Sio, Yang Yie, Herrera‐Luis, Esther, Espuela‐Ortiz, Antonio, Perez‐Garcia, Javier, Pino‐Yanes, Maria, Burchard, Esteban G., Potočnik, Uroš, Gorenjak, Mario, Palmer, Colin, Maroteau, Cyrielle, Turner, Steve, Verhamme, Katia, Karimi, Leila, Mukhopadhyay, Somnath, Timens, Wim, Hiemstra, Pieter S., Pijnenburg, Mariëlle W., Neighbors, Margaret, Grimbaldeston, Michele A., Tew, Gaik W., Brandsma, Corry A., Berce, Vojko, Aliee, Hananeh, Theis, Fabian, Sin, Don D., Li, Xuan, Berge, Maarten, Maitland‐van der Zee, Anke H., Koppelman, Gerard H.

“…The COPD analysis was conducted in the Lung Health Study (LHS)-2, including 1116 COPD patients (ICS, n = 559 or placebo, n = 557) with lung function…”
Get full text