Search Results - "Teves, Maria E."
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Spontaneous preterm birth: advances toward the discovery of genetic predisposition
Published in American journal of obstetrics and gynecology (01-03-2018)“…Evidence from family and twin-based studies provide strong support for a significant contribution of maternal and fetal genetics to the timing of parturition…”
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Intraflagellar transport protein IFT20 is essential for male fertility and spermiogenesis in mice
Published in Molecular biology of the cell (15-11-2016)“…Intraflagellar transport (IFT) is a conserved mechanism thought to be essential for the assembly and maintenance of cilia and flagella. However, little is…”
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3
Sperm Differentiation: The Role of Trafficking of Proteins
Published in International journal of molecular sciences (24-05-2020)“…Sperm differentiation encompasses a complex sequence of morphological changes that takes place in the seminiferous epithelium. In this process, haploid round…”
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SPAG17 Is Required for Male Germ Cell Differentiation and Fertility
Published in International journal of molecular sciences (21-04-2018)“…encodes a protein present in the axoneme central pair complex of motile cilia and flagella. A mutation in this gene has been reported to be associated with…”
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Molecular mechanism for human sperm chemotaxis mediated by progesterone
Published in PloS one (08-12-2009)“…Sperm chemotaxis is a chemical guiding mechanism that may orient spermatozoa to the egg surface. A picomolar concentration gradient of Progesterone (P), the…”
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Sperm Chromatin Status and DNA Fragmentation in Mouse Species with Divergent Mating Systems
Published in International journal of molecular sciences (01-11-2023)“…Sperm DNA integrity and chromatin status serve as pivotal indicators of sperm quality, given their intricate link to sperm function, embryo development, and…”
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Intraflagellar transporter protein 140 (IFT140), a component of IFT‐A complex, is essential for male fertility and spermiogenesis in mice
Published in Cytoskeleton (Hoboken, N.J.) (01-02-2018)“…Intraflagellar transport (IFT) is a conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. However, little is…”
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8
A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella
Published in Development (Cambridge) (01-03-2015)“…A key event in the process of spermiogenesis is the formation of the flagella, which enables sperm to reach eggs for fertilization. Yeast two-hybrid studies…”
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Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat
Published in PloS one (21-10-2014)“…SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice…”
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Mammalian axoneme central pair complex proteins: Broader roles revealed by gene knockout phenotypes
Published in Cytoskeleton (Hoboken, N.J.) (01-01-2016)“…The axoneme genes, their encoded proteins, their functions and the structures they form are largely conserved across species. Much of our knowledge of the…”
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Human DENND1A.V2 Drives Cyp17a1 Expression and Androgen Production in Mouse Ovaries and Adrenals
Published in International journal of molecular sciences (06-04-2020)“…The locus is associated with polycystic ovary syndrome (PCOS), a disorder characterized by androgen excess. Theca cells from ovaries of PCOS women have…”
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Discovery of rare ancestry-specific variants in the fetal genome that confer risk of preterm premature rupture of membranes (PPROM) and preterm birth
Published in BMC medical genetics (05-10-2018)“…Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth, a complication that is more common in African Americans…”
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Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes
Published in PloS one (27-03-2017)“…Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and…”
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Spag16, an axonemal central apparatus gene, encodes a male germ cell nuclear speckle protein that regulates SPAG16 mRNA expression
Published in PloS one (31-05-2011)“…Spag16 is the murine orthologue of Chlamydomonas reinhardtii PF20, a protein known to be essential to the structure and function of the "9+2" axoneme. In…”
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The dynamic organelle primary cilia: emerging roles in organ fibrosis
Published in Current opinion in rheumatology (01-11-2021)“…Purpose of review Primary cilia, the antenna-like organelles on most mammalian cells, host key components of multiple morphogen signal transduction pathways…”
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Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells
Published in Asian journal of andrology (01-01-2015)“…Mammalian spermatogenesis is a well-organized process of cell development and differentiation. Meiosis expressed gene 1 (MEIG1) plays an essential role in the…”
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Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid acrosomal vesicles
Published in PloS one (29-06-2012)“…Mouse RC/BTB2 is an unstudied protein of the RCC1 (Regulator of Chromosome Condensation) superfamily. Because of the significant remodeling of chromatin that…”
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miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis
Published in Endocrinology (Philadelphia) (01-08-2019)“…Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder of reproductive-age women involving overproduction of ovarian androgens and, in some…”
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TSSK3, a novel target for male contraception, is required for spermiogenesis
Published in Molecular reproduction and development (01-11-2021)“…We have previously shown that members of the family of testis‐specific serine/threonine kinases (TSSKs) are post‐meiotically expressed in testicular germ cells…”
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Hedgehog signaling regulates Wolffian duct development through the primary cilium
Published in Biology of reproduction (13-02-2023)“…Primary cilia play pivotal roles in embryonic patterning and organogenesis through transduction of the Hedgehog signaling pathway (Hh). Although mutations in…”
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