Search Results - "Teuscher, Nathan"

Population Pharmacokinetic-Pharmacodynamic Modeling of a Novel Methylphenidate Extended-Release Orally Disintegrating Tablet in Pediatric Patients With Attention-Deficit/Hyperactivity Disorder by Teuscher, Nathan S, Sikes, Carolyn R, McMahen, Russ, Engelking, Dorothy

“…A methylphenidate (MPH) extended-release orally disintegrating tablet (MPH XR-ODT) formulation was recently approved for attention-deficit/hyperactivity…”
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Comments on D.A. Noe's papers on noncompartmental pharmacokinetic analysis: Performance characteristics of the adjusted r 2 algorithm for determining the start of the terminal disposition phase and comparison with a simple r 2 algorithm and a visual inspection method https://onlinelibrary.wiley.com/doi/10.1002/pst.1979 and Criteria for reporting noncompartmental estimates of half-life and area under the curve extrapolated to infinity https://onlinelibrary.wiley.com/doi/10.1002/pst.1978 by Weiner, Daniel, Teuscher, Nathan S

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Comments on D.A. Noe's papers on noncompartmental pharmacokinetic analysis: Performance characteristics of the adjusted r2 algorithm for determining the start of the terminal disposition phase and comparison with a simple r2 algorithm and a visual inspection method https://onlinelibrary.wiley.com/doi/10.1002/pst.1979 and Criteria for reporting noncompartmental estimates of half‐life and area under the curve extrapolated to infinity https://onlinelibrary.wiley.com/doi/10.1002/pst.1978 by Weiner, Daniel, Teuscher, Nathan S.

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Evaluation of covariate effects using forest plots and introduction to the coveffectsplot R package by Marier, Jean‐Francois, Teuscher, Nathan, Mouksassi, Mohamad‐Samer

“…The current tutorial describes why forest plots are needed for an effective communication of covariates effects, how they are constructed, and how they should…”
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Single-dose pharmacokinetics of methylphenidate extended-release multiple layer beads administered as intact capsule or sprinkles versus methylphenidate immediate-release tablets (Ritalin(®)) in healthy adult volunteers by Adjei, Akwete, Teuscher, Nathan S, Kupper, Robert J, Chang, Wei-Wei, Greenhill, Laurence, Newcorn, Jeffrey H, Connor, Daniel F, Wigal, Sharon

“…The purpose of this study was to evaluate the relative bioavailability and safety of a multilayer extended-release bead methylphenidate (MPH) hydrochloride 80…”
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The history and future of population pharmacokinetic analysis in drug development by Teuscher, Nathan

“…The analysis of pharmacokinetic data has been in a constant state of evolution since the introduction of the term pharmacokinetics. Early work focused on…”
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Steady-State Bioavailability of Extended-Release Methylphenidate (MPH-MLR) Capsule vs. Immediate-Release Methylphenidate Tablets in Healthy Adult Volunteers by Adjei, Akwete, Kupper, Robert J., Teuscher, Nathan S., Wigal, Sharon, Sallee, Floyd, Childress, Ann, Kollins, Scott H., Greenhill, Laurence

“…Objectives The objective of the study was to determine the relative bioavailability of an extended-release multilayer bead formulation of methylphenidate…”
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Data standards for model-informed drug development: an ISoP initiative by Radivojevic, Andrijana, Corrigan, Brian, Downie, Nicholas, Fox, Robert, Fiedler-Kelly, Jill, Liu, Huan, Melhem, Murad, Radke, David, Schaefer, Peter, Su, Jing, Swat, Maciej J, Teuscher, Nathan S, Thanneer, Neelima, Zong, Alice, Wilkins, Justin J

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Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder by Teuscher, Nathan S, Adjei, Akwete, Findling, Robert L, Greenhill, Laurence L, Kupper, Robert J, Wigal, Sharon

“…A new multilayer-bead formulation of extended-release methylphenidate hydrochloride (MPH-MLR) has been evaluated in pharmacokinetic studies in healthy adults…”
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Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture by Shu, Cathaleen, Shen, Hong, Teuscher, Nathan S, Lorenzi, Philip J, Keep, Richard F, Smith, David E

“…Recent studies have established the functional and molecular presence of a high-affinity peptide transporter, PEPT2, in whole tissue rat choroid plexus…”
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Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice by Teuscher, Nathan S., Shen, Hong, Shu, Cathaleen, Xiang, Jianming, Keep, Richard F., Smith, David E.

“…PEPT2 is functionally active and localized to the apical membrane of rat choroid plexus epithelial cells. However, little is known about the transport…”
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A Novel Study Using Accelerated Mass Spectrometry to Evaluate the Pharmacokinetics of Total (14)C AL-8309 (Tandospirone) Following Topical Ocular Administration in Healthy Male Subjects by Iyer, Ganesh R, Patel, Yamini, Teuscher, Nathan S

“…The primary objective of this study is to characterize the pharmacokinetics of total (14)C concentrations following bilateral, topical ocular drops of…”
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A food effect study and dose proportionality study to assess the pharmacokinetics and safety of bardoxolone methyl in healthy volunteers by Teuscher, Nathan S., Kelley, Richard J., Dumas, Emily O., Klein, Cheri Enders, Awni, Walid M., Meyer, Colin J.

“…This study investigated the effect of food on the plasma pharmacokinetics of bardoxolone methyl, an antioxidant inflammation modulator, at a 20 mg dose, and…”
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Data standards for model-informed drug development: an ISoP initiative by Radivojevic, Andrijana, Corrigan, Brian, Downie, Nicholas, Fox, Robert, Fiedler-Kelly, Jill, Liu, Huan, Melhem, Murad, Radke, David, Schaefer, Peter, Su, Jing, Swat, Maciej J., Teuscher, Nathan S., Thanneer, Neelima, Zong, Alice, Wilkins, Justin J.

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A Novel Study Using Accelerated Mass Spectrometry to Evaluate the Pharmacokinetics of Total 14C AL-8309 (Tandospirone) Following Topical Ocular Administration in Healthy Male Subjects by Iyer, Ganesh R., Patel, Yamini, Teuscher, Nathan S.

“…The primary objective of this study is to characterize the pharmacokinetics of total 14C concentrations following bilateral, topical ocular drops of…”
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PEPT2-mediated uptake of neuropeptides in rat choroid plexus by TEUSCHER, Nathan S, KEEP, Richard F, SMITH, David E

“…The peptide transporter PEPT2 was recently shown to be functionally active in rat choroid plexus, suggesting that it may play a role in neuropeptide…”
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Sutimlimab Pharmacokinetics and Pharmacodynamics in Patients with Cold Agglutinin Disease by Frank, Thomas, Kovar, Andreas, Strougo, Ashley, Vage, Chandravathi, Teuscher, Nathan, Wong, Nancy

“…Sutimlimab, a humanized monoclonal antibody targeting the classic complement pathway, is approved in the United States, Japan, and the European Union for the…”
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POPULATION PHARMACOKINETICS AND PHARMACODYNAMICS OF OZANIMOD IN ULCERATIVE COLITIS by Tatosian, Daniel, Shen, Jun, Chen, Lu, Lavigne, Jean, Teuscher, Nathan, Harris, Sarah, Chitkara, Denesh, Tirucherai, Giridhar, Marta, Cecilia

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POPULATION PHARMACOKINETICS OF OZANIMOD AND ACTIVE METABOLITE CC112273 IN PATIENTS WITH ULCERATIVE COLITIS by Shen, Jun, Tatosian, Daniel, Sid-Otmane, Lamia, Teuscher, Nathan, Chen, Lu, Zhang, Peijin, Tirucherai, Giridhar, Chitkara, Denesh, Marta, Cecilia

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A distributed delay approach for modeling delayed outcomes in pharmacokinetics and pharmacodynamics studies by Hu, Shuhua, Dunlavey, Michael, Guzy, Serge, Teuscher, Nathan

“…A distributed delay approach was proposed in this paper to model delayed outcomes in pharmacokinetics and pharmacodynamics studies. This approach was shown to…”
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