Search Results - "Teumer, Alexander"

Common Methods for Performing Mendelian Randomization by Teumer, Alexander

“…Mendelian randomization (MR) is a framework for assessing causal inference using cross-sectional data in combination with genetic information. This paper…”
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Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome by Porcu, Eleonora, Sadler, Marie C., Lepik, Kaido, Auwerx, Chiara, Wood, Andrew R., Weihs, Antoine, Sleiman, Maroun S. Bou, Ribeiro, Diogo M., Bandinelli, Stefania, Tanaka, Toshiko, Nauck, Matthias, Völker, Uwe, Delaneau, Olivier, Metspalu, Andres, Teumer, Alexander, Frayling, Timothy, Santoni, Federico A., Reymond, Alexandre, Kutalik, Zoltán

“…Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes,…”
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Copy Number Variations and Cognitive Phenotypes in Unselected Populations by Männik, Katrin, Mägi, Reedik, Macé, Aurélien, Cole, Ben, Guyatt, Anna L, Shihab, Hashem A, Maillard, Anne M, Alavere, Helene, Kolk, Anneli, Reigo, Anu, Mihailov, Evelin, Leitsalu, Liis, Ferreira, Anne-Maud, Nõukas, Margit, Teumer, Alexander, Salvi, Erika, Cusi, Daniele, McGue, Matt, Iacono, William G, Gaunt, Tom R, Beckmann, Jacques S, Jacquemont, Sébastien, Kutalik, Zoltán, Pankratz, Nathan, Timpson, Nicholas, Metspalu, Andres, Reymond, Alexandre

“…IMPORTANCE: The association of copy number variations (CNVs), differing numbers of copies of genetic sequence at locations in the genome, with phenotypes such…”
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Genome-wide association study of chronic periodontitis in a general German population by Teumer, Alexander, Holtfreter, Birte, Völker, Uwe, Petersmann, Astrid, Nauck, Matthias, Biffar, Reiner, Völzke, Henry, Kroemer, Heyo K., Meisel, Peter, Homuth, Georg, Kocher, Thomas

“…Aim To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS). Materials and Methods A GWAS was performed in 4032…”
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Imputation-powered whole-exome analysis identifies genes associated with kidney function and disease in the UK Biobank by Wuttke, Matthias, König, Eva, Katsara, Maria-Alexandra, Kirsten, Holger, Farahani, Saeed Khomeijani, Teumer, Alexander, Li, Yong, Lang, Martin, Göcmen, Burulca, Pattaro, Cristian, Günzel, Dorothee, Köttgen, Anna, Fuchsberger, Christian

“…Genome-wide association studies have discovered hundreds of associations between common genotypes and kidney function but cannot comprehensively investigate…”
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Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population by APPEL, Katja, SCHWAHN, Christian, BIFFAR, Reiner, NAUCK, Matthias, VÖLZKE, Henry, FREYBERGER, Harald J, GRABE, Hans J, MAHLER, Jessie, SCHULZ, Andrea, SPITZER, Carsten, FENSKE, Kristin, STENDER, Jan, BARNOW, Sven, JOHN, Ulrich, TEUMER, Alexander

“…Childhood maltreatment and depressive disorders have both been associated with a dysregulation of the hypothalamic-pituitary-adrenal axis. The FKBP5 gene codes…”
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Correction: Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks by Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B, Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“…[This corrects the article DOI: 10.1371/journal.pone.0271610.]…”
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Genome-wide associations of aortic distensibility suggest causality for aortic aneurysms and brain white matter hyperintensities by Francis, Catherine M., Futschik, Matthias E., Huang, Jian, Bai, Wenjia, Sargurupremraj, Muralidharan, Teumer, Alexander, Breteler, Monique M. B., Petretto, Enrico, Ho, Amanda S. R., Amouyel, Philippe, Engelter, Stefan T., Bülow, Robin, Völker, Uwe, Völzke, Henry, Dörr, Marcus, Imtiaz, Mohammed-Aslam, Aziz, N. Ahmad, Lohner, Valerie, Ware, James S., Debette, Stephanie, Elliott, Paul, Dehghan, Abbas, Matthews, Paul M.

“…Aortic dimensions and distensibility are key risk factors for aortic aneurysms and dissections, as well as for other cardiovascular and cerebrovascular…”
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Analysis of epidemiological association patterns of serum thyrotropin by combining random forests and Bayesian networks by Becker, Ann-Kristin, Ittermann, Till, Dörr, Markus, Felix, Stephan B, Nauck, Matthias, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Kaderali, Lars, Nath, Neetika

“…Background Approaching epidemiological data with flexible machine learning algorithms is of great value for understanding disease-specific association…”
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A genome-wide association study of metabolic traits in human urine by Suhre, Karsten, Wallaschofski, Henri, Raffler, Johannes, Friedrich, Nele, Haring, Robin, Michael, Kathrin, Wasner, Christina, Krebs, Alexander, Kronenberg, Florian, Chang, David, Meisinger, Christa, Wichmann, H-Erich, Hoffmann, Wolfgang, Völzke, Henry, Völker, Uwe, Teumer, Alexander, Biffar, Reiner, Kocher, Thomas, Felix, Stephan B, Illig, Thomas, Kroemer, Heyo K, Gieger, Christian, Römisch-Margl, Werner, Nauck, Matthias

“…Karsten Suhre and colleagues report a genome-wide association study of metabolic traits in human urine, using NMR spectrometry to measure 59 metabolites in…”
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Discovery of novel eGFR-associated multiple independent signals using a quasi-adaptive method by Ghasemi, Sahar, Becker, Tim, Grabe, Hans J, Teumer, Alexander

“…A decreased estimated glomerular filtration rate (eGFR) leading to chronic kidney disease is a significant public health problem. Kidney function is a…”
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Mendelian randomization indicates causal effects of estradiol levels on kidney function in males by Nasr, M Kamal, Schurmann, Claudia, Böttinger, Erwin P, Teumer, Alexander

“…Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological studies observed an association between sex hormones, including estradiol,…”
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Methylation Patterns of the FKBP5 Gene in Association with Childhood Maltreatment and Depressive Disorders by Großmann, Nora L, Weihs, Antoine, Kühn, Luise, Sauer, Susann, Röh, Simone, Wiechmann, Tobias, Rex-Haffner, Monika, Völzke, Henry, Völker, Uwe, Binder, Elisabeth B, Teumer, Alexander, Homuth, Georg, Klinger-König, Johanna, Grabe, Hans J

“…Childhood maltreatment is an important risk factor for adult depression and has been associated with changes in the hypothalamic pituitary adrenal (HPA) axis,…”
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TREML2 Gene Expression and Its Missense Variant rs3747742 Associate with White Matter Hyperintensity Volume and Alzheimer's Disease-Related Brain Atrophy in the General Population by Kühn, Annemarie Luise, Frenzel, Stefan, Teumer, Alexander, Wittfeld, Katharina, Garvert, Linda, Weihs, Antoine, Homuth, Georg, Prokisch, Holger, Bülow, Robin, Nauck, Matthias, Völker, Uwe, Völzke, Henry, Grabe, Hans Jörgen, Van der Auwera, Sandra

“…Although the common pathology of Alzheimer's disease (AD) and white matter hyperintensities (WMH) is disputed, the gene has been implicated in both conditions:…”
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Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study by Ellervik, Christina, Mora, Samia, Kuś, Aleksander, Åsvold, Bjørn, Marouli, Eirini, Deloukas, Panos, Sterenborg, Rosalie B T M, Teumer, Alexander, Burgess, Stephen, Sabater-Lleal, Maria, Huffman, Jennifer, Johnson, Andrew D, Trégouet, David-Alexandre, Smith, Nicolas L, Medici, Marco, DeVries, Paul S, Chasman, Daniel I, Kjaergaard, Alisa D

“…Untreated hypothyroidism is associated with acquired von Willebrand syndrome, and hyperthyroidism is associated with increased thrombosis risk. However, the…”
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Limited evidence for blood eQTLs in human sexual dimorphism by Porcu, Eleonora, Claringbould, Annique, Weihs, Antoine, Lepik, Kaido, Richardson, Tom G, Völker, Uwe, Santoni, Federico A, Teumer, Alexander, Franke, Lude, Reymond, Alexandre, Kutalik, Zoltán

“…The genetic underpinning of sexual dimorphism is very poorly understood. The prevalence of many diseases differs between men and women, which could be in part…”
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Effects of Apolipoprotein E polymorphism on carotid intima-media thickness, incident myocardial infarction and incident stroke by Pitchika, Anitha, Markus, Marcello Ricardo Paulista, Schipf, Sabine, Teumer, Alexander, Van der Auwera, Sandra, Nauck, Matthias, Dörr, Marcus, Felix, Stephan, Grabe, Hans-Jörgen, Völzke, Henry, Ittermann, Till

“…The Apolipoprotein E (APOE) gene polymorphism (rs429358 and rs7412) shows a well-established association with lipid profiles, but its effect on cardiovascular…”
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Polygenic Architecture of Human Neuroanatomical Diversity by Biton, Anne, Traut, Nicolas, Poline, Jean-Baptiste, Aribisala, Benjamin S, Bastin, Mark E, Bülow, Robin, Cox, Simon R, Deary, Ian J, Fukunaga, Masaki, Grabe, Hans J, Hagenaars, Saskia, Hashimoto, Ryota, Kikuchi, Masataka, Muñoz Maniega, Susana, Nauck, Matthias, Royle, Natalie A, Teumer, Alexander, Valdés Hernández, Maria, Völker, Uwe, Wardlaw, Joanna M, Wittfeld, Katharina, Yamamori, Hidenaga, Bourgeron, Thomas, Toro, Roberto

“…Abstract We analyzed the genomic architecture of neuroanatomical diversity using magnetic resonance imaging and single nucleotide polymorphism (SNP) data from…”
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Genome-wide association study of 1,5-anhydroglucitol identifies novel genetic loci linked to glucose metabolism by Li, Man, Maruthur, Nisa M., Loomis, Stephanie J., Pietzner, Maik, North, Kari E., Mei, Hao, Morrison, Alanna C., Friedrich, Nele, Pankow, James S., Nauck, Matthias, Boerwinkle, Eric, Teumer, Alexander, Selvin, Elizabeth, Köttgen, Anna

“…1,5-anhydroglucitol (1,5-AG) is a biomarker of hyperglycemic excursions associated with diabetic complications. Because of its structural similarity to…”
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Asymmetry within and around the human planum temporale is sexually dimorphic and influenced by genes involved in steroid hormone receptor activity by Guadalupe, Tulio, Zwiers, Marcel P., Wittfeld, Katharina, Teumer, Alexander, Vasquez, Alejandro Arias, Hoogman, Martine, Hagoort, Peter, Fernandez, Guillen, Buitelaar, Jan, van Bokhoven, Hans, Hegenscheid, Katrin, Völzke, Henry, Franke, Barbara, Fisher, Simon E., Grabe, Hans J., Francks, Clyde

“…The genetic determinants of cerebral asymmetries are unknown. Sex differences in asymmetry of the planum temporale (PT), that overlaps Wernicke's classical…”
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