Search Results - "Tetteh, Leticia"
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Phase I/II Study of the Src Inhibitor Dasatinib in Combination With Erlotinib in Advanced Non–Small-Cell Lung Cancer
Published in Journal of clinical oncology (10-03-2010)“…Src family kinase (SFK) proteins are frequently activated in cancer and can coordinate tumor cell growth, survival, invasion, and angiogenesis. Given the…”
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Combined BRAF and HSP90 Inhibition in Patients with Unresectable BRAF V600E -Mutant Melanoma
Published in Clinical cancer research (15-11-2018)“…BRAF inhibitors are clinically active in patients with advanced BRAF -mutant melanoma, although acquired resistance remains common. Preclinical studies…”
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Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial
Published in Molecular cancer therapeutics (01-08-2006)“…Purpose: Resistance to topoisomerase (topo) I inhibitors has been related to down-regulation of nuclear target enzyme, whereas sensitization to topo II…”
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High dose bolus (HDB) interleukin-2 (IL2) and concurrent low dose ipilimumab followed sequentially by nivolumab in patients with advanced melanoma after failure of anti-PD1-based immunotherapy and BRAF-MEK inhibition
Published in Journal of clinical oncology (01-06-2024)“…9543 Background: Options are limited for patients with advanced metastatic melanoma who have disease progression following anti-PD1-based immunotherapy and…”
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Safety, correlative markers, and clinical results of adjuvant nivolumab in combination with vaccine in resected high-risk metastatic melanoma
Published in Clinical cancer research (15-02-2015)“…The anti-programmed death-1 (PD-1) antibody nivolumab (BMS-936558) has clinical activity in patients with metastatic melanoma. Nivolumab plus vaccine was…”
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Combined BRAF, MEK, and heat‐shock protein 90 inhibition in advanced BRAF V600‐mutant melanoma
Published in Cancer (01-01-2024)“…Background Resistance to BRAF and MEK inhibitors in BRAF V600‐mutant melanoma is common. Multiple resistance mechanisms involve heat‐shock protein 90 (HSP90)…”
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Phase I study of vemurafenib (VEM) and cobimetinib (COB) with heat shock protein 90 (HSP90) inhibitor XL888 in advanced BRAFV600 mutant melanoma
Published in Journal of clinical oncology (20-05-2019)“…Abstract only 9553 Background: Resistance to BRAF+MEK inhibitors(i) in BRAF-mutant melanoma is common. Multiple resistance mechanisms involve HSP90 clients,…”
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A Phase I, Pharmacokinetic, and Pharmacodynamic Study of Panobinostat, an HDAC Inhibitor, Combined with Erlotinib in Patients with Advanced Aerodigestive Tract Tumors
Published in Clinical cancer research (15-03-2014)“…Panobinostat, a histone deacetylase (HDAC) inhibitor, enhances antiproliferative activity in non-small cell lung cancer (NSCLC) cell lines when combined with…”
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Phase I study of vemurafenib and heat shock protein 90 (HSP90) inhibitor XL888 in metastatic BRAF V600 mutant melanoma
Published in Journal of clinical oncology (20-05-2016)“…Abstract only…”
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Safety and efficacy of adjuvant anti-PD1 therapy (nivolumab) in combination with vaccine in resected high-risk metastatic melanoma
Published in Journal of clinical oncology (20-05-2013)“…Abstract only 9056^ Background: Nivolumab (BMS-936558), a fully human monoclonal antibody targeting the programmed death-1 (PD-1) receptor, has demonstrated…”
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The absolute bioavailability of oral vinorelbine in patients with solid tumors
Published in Cancer chemotherapy and pharmacology (01-12-2005)“…Due to advances in the methods used to quantitate vinorelbine, this study was conducted to characterize fully the bioavailability of an oral dosage form of…”
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