Search Results - "Tetsuji Kobata"

IL‐33 activates eosinophils of visceral adipose tissue both directly and via innate lymphoid cells by Hashiguchi, Masaaki, Kashiwakura, Yuji, Kojima, Hidefumi, Kobayashi, Ayano, Kanno, Yumiko, Kobata, Tetsuji

“…Eosinophils are multifunctional leukocytes involved in allergic reactions as well as adipose tissue regulation. IL‐5 is required for eosinophil survival;…”
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Tumor necrosis factor superfamily member (TNFSF) 13 (APRIL) and TNFSF13B (BAFF) downregulate homeostatic immunoglobulin production in the intestines by Hashiguchi, Masaaki, Kashiwakura, Yuji, Kanno, Yumiko, Kojima, Hidefumi, Kobata, Tetsuji

“…•APRIL and BAFF induce proliferation of PP B cells.•PP B cells are phenotypically distinct from splenic B cells.•Ig downregulation in intestine by APRIL and…”
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Carbohydrate Mimicry between Human Ganglioside GM1 and Campylobacter jejuni Lipooligosaccharide Causes Guillain-Barré Syndrome by Yuki, Nobuhiro, Susuki, Keiichiro, Koga, Michiaki, Nishimoto, Yukihiro, Odaka, Masaaki, Hirata, Koichi, Taguchi, Kyoji, Miyatake, Tadashi, Furukawa, Koichi, Kobata, Tetsuji, Yamada, Mitsunori, Sela, Michael

“…Molecular mimicry between microbial and self-components is postulated as the mechanism that accounts for the antigen and tissue specificity of immune responses…”
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Increased B cell-activating factor promotes tumor invasion and metastasis in human pancreatic cancer by Koizumi, Mitsuhito, Hiasa, Yoichi, Kumagi, Teru, Yamanishi, Hirofumi, Azemoto, Nobuaki, Kobata, Tetsuji, Matsuura, Bunzo, Abe, Masanori, Onji, Morikazu

“…B cell-activating factor (BAFF) is a cytokine belonging to the tumor necrosis factor (TNF) superfamily. It has been reported that BAFF is elevated in patients…”
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Peyer's patch innate lymphoid cells regulate commensal bacteria expansion by Hashiguchi, Masaaki, Kashiwakura, Yuji, Kojima, Hidefumi, Kobayashi, Ayano, Kanno, Yumiko, Kobata, Tetsuji

“…Highlights • Peyer's patch contained IL-22- and IFN-γ-producing innate lymphoid cells. • Antibiotics decreased IL-22 production from Peyer's patch innate…”
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TACI attenuates antibody production costimulated by BAFF‐R and CD40 by Sakurai, Daisuke, Kanno, Yumiko, Hase, Hidenori, Kojima, Hidefumi, Okumura, Ko, Kobata, Tetsuji

“…B cell activating factor of the TNF family (BAFF), plays critical roles in B cell survival, activation, differentiation, and antibody (Ab) production. BAFF…”
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Abnormal B Lymphocyte Development and Autoimmunity in Hypoxia-Inducible Factor 1α-Deficient Chimeric Mice by Kojima, Hidefumi, Gu, Hua, Nomura, Saeko, Caldwell, Charles C., Kobata, Tetsuji, Carmeliet, Peter, Semenza, Gregg L., Sitkovsky, Michail V.

“…Immune cells are exposed to low oxygen tensions as they develop and migrate between blood and different tissues, but the mechanisms by which lymphocytes adapt…”
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Crucial Role of Inhibitor of DNA Binding/Differentiation in the Vascular Endothelial Growth Factor-Induced Activation and Angiogenic Processes of Human Endothelial Cells by Sakurai, Daisuke, Tsuchiya, Naoyuki, Yamaguchi, Akihiro, Okaji, Yurai, Tsuno, Nelson H, Kobata, Tetsuji, Takahashi, Koki, Tokunaga, Katsushi

“…Angiogenesis plays a pivotal role in the aggressive proliferation of synovial cells in rheumatoid arthritis. We have previously reported the overexpression of…”
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Expression of BAFF-R and TACI in reactive lymphoid tissues and B-cell lymphomas by Wada, Kiriko, Maeda, Kunihiko, Tajima, Katsushi, Kato, Takeo, Kobata, Tetsuji, Yamakawa, Mitsunori

“…Aims:  The receptor for B‐cell‐activating factor belonging to the tumour necrosis factor family (BAFF‐R) and transmembrane activator and calcium modulator and…”
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Generation of Plasma Cells From Peripheral Blood Memory B Cells: Synergistic Effect of Interleukin-10 and CD27/CD70 Interaction by Agematsu, Kazunaga, Nagumo, Haruo, Oguchi, Yumiko, Nakazawa, Takayuki, Fukushima, Keitaro, Yasui, Kozo, Ito, Susumu, Kobata, Tetsuji, Morimoto, Chikao, Komiyama, Atsushi

“…B cells can differentiate into the antibody-secreting cells, plasma cells, whereas the crucial signals that positively control the entry into the pathway to…”
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Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation by Nakano, H, Sakon, S, Koseki, H, Takemori, T, Tada, K, Matsumoto, M, Munechika, E, Sakai, T, Shirasawa, T, Akiba, H, Kobata, T, Santee, S M, Ware, C F, Rennert, P D, Taniguchi, M, Yagita, H, Okumura, K

“…TRAF5 [tumor necrosis factor (TNF) receptor-associated factor 5] is implicated in NF-κB and c-Jun NH 2 -terminal kinase/stress-activated protein kinase…”
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CD27-Mediated Activation of Murine NK Cells by Takeda, Kazuyoshi, Oshima, Hideo, Hayakawa, Yoshihiro, Akiba, Hisaya, Atsuta, Machiko, Kobata, Tetsuji, Kobayashi, Kimio, Ito, Mamoru, Yagita, Hideo, Okumura, Ko

“…CD27, a member of the TNF receptor superfamily, has been implicated in T cell activation, T cell development, and T cell-dependent Ab production by B cells. In…”
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Blockade of CD134 (OX40)-CD134L interaction ameliorates lethal acute graft-versus-host disease in a murine model of allogeneic bone marrow transplantation by Tsukada, Nobuhiro, Akiba, Hisaya, Kobata, Tetsuji, Aizawa, Yoshifusa, Yagita, Hideo, Okumura, Ko

“…Expression of CD134 (OX40) on activated CD4+ T cells has been observed in acute graft-versus-host disease (GVHD) after human and rat allogeneic bone marrow…”
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BAFF-R is Expressed on B-cell Lymphomas Depending on their Origin, and is Related to Proliferation Index of Nodal Diffuse Large B-cell Lymphomas by Takahata, Hiroyuki, Ohara, Nobuya, Ichimura, Kouichi, Tanaka, Takehiro, Sato, Yasuharu, Morito, Toshiaki, Takata, Katsuyoshi, Kojima, Masaru, Kobata, Tetsuji, Yoshino, Tadashi

“…B-cell activating factor receptor (BAFF-R) is one of three known receptors for BAFF. BAFF-R is required for B-cell maturation and survival. We tried to…”
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CD27 and CD40 Inhibit p53-independent Mitochondrial Pathways in Apoptosis of B Cells Induced by B Cell Receptor Ligation by Hase, Hidenori, Kanno, Yumiko, Kojima, Hidefumi, Morimoto, Chikao, Okumura, Ko, Kobata, Tetsuji

“…B cells in the germinal center are known to undergo apoptosis after B cell receptor (BCR) ligation, a process relevant to immunological tolerance. Human CD27…”
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Involvement of CD70–CD27 interactions in the induction of experimental autoimmune encephalomyelitis by Nakajima, Atsuo, Oshima, Hideo, Nohara, Chiyoko, Morimoto, Shinji, Yoshino, Shin-ichi, Kobata, Tetsuji, Yagita, Hideo, Okumura, Ko

“…CD70/CD27 are cell surface molecules belonging to the TNF/TNF-receptor families. Ligation of CD27 by its ligand CD70 is thought to be important in T cell…”
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Characterization of murine CD70 by molecular cloning and mAb by Oshima, H, Nakano, H, Nohara, C, Kobata, T, Nakajima, A, Jenkins, N A, Gilbert, D J, Copeland, N G, Muto, T, Yagita, H, Okumura, K

“…CD27, a member of the tumor necrosis factor (TNF) receptor family, has been implicated in T cell activation, T cell development and T-dependent antibody…”
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Fine‐tuning of antigen‐specific immune responses by regulatory T cells activated via antigen recognition–independent and humoral factor–dependent mechanisms by Kojima, Hidefumi, Kashiwakura, Yuji, Kanno, Yumiko, Hashiguchi, Masaaki, Kobata, Tetsuji

“…CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) are highly sensitive to IL‐2, one of the many cytokines produced during immune responses, for their development,…”
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IL-21 and IL-5 coordinately induce surface IgA+ cells by Hashiguchi, Masaaki, Kashiwakura, Yuji, Kanno, Yumiko, Kojima, Hidefumi, Kobata, Tetsuji

“…•Retinoic acid and TGF-β1 is enough for IgA secretion but not for surface IgA in vitro.•The addition of rIL-5 and rIL-21 coordinately induce IgA+ cells in…”
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Peyer’s patches contain abundant isotype-switched B cells with activated phenotypes and are inductive sites for T-independent anti-DNA IgA by Hashiguchi, Masaaki, Kashiwakura, Yuji, Kojima, Hidefumi, Kanno, Yumiko, Kobata, Tetsuji

“…•Activated phenotypes of isotype-switched PP B cells were more abundant than spleen’s.•Immunoglobulin A (IgA) from PP B cells dominantly reacted to DNA.•PPs…”
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