Search Results - "Tetrault, Tanya"

1223 Non-viral targeted knock-in of a KRAS G12D specific TCR, CD8αβ, and chimeric cytokine receptor in the TRAC locus outperforms lentiviral-based engineering of T cells by Narayan, Santosh, Drain, Allison P, Swanson, Nathaniel, Rouillard, Nicholas, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

“…BackgroundThe AFNT-212 cell therapy consists of autologous CD8+ and CD4+ T cells expressing 1) a T Cell Receptor (TCR) specific for the prevalent oncogenic…”
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355 Directing a high avidity KRAS G12D-specific TCR engineered with a CD8αβ co-receptor and chimeric cytokine receptor using non-viral knock-in enhances anti-tumor responses by Drain, Allison P, Rouillard, Nicholas, Swanson, Nathaniel, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Black, Cheryl, Parsons, James, Thomas, Anthony, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Nguyen, Vince, Priyata, Iqraa, Vidyasagar, Sarah, Francis, Joshua, He, Xingyue, Browne, Patrick J, Lamothe, Rebecca C, Storlie, Meghan D, Cost, Gregory J, Schmitt, Thomas M, Greenberg, Philip D, Chandran, Smita S, Klebanoff, Christopher A, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loic

“…BackgroundAdoptive T cell therapy has demonstrated clinical activity in a subset of patients with solid tumors; however, consistent responses will require…”
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Increasing Enzyme Mannose-6-Phosphate Levels but Not Miglustat Coadministration Enhances the Efficacy of Enzyme Replacement Therapy in Pompe Mice by Anding, Allyson, Kinton, Sofia, Baranowski, Kaitlyn, Brezzani, Alexander, De Busser, Hilde, Dufault, Michael R, Finn, Patrick, Keefe, Kelly, Tetrault, Tanya, Li, Yi, Qiu, Weiliang, Raes, Katrien, Vitse, Olivier, Zhang, Mindy, Ziegler, Robin, Sardi, S Pablo, Hunter, Bridge, George, Kelly

“…Pompe disease is a rare glycogen storage disorder caused by a deficiency in the lysosomal enzyme acid -glucosidase, which leads to muscle weakness, cardiac and…”
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Abstract 10: Non-viral engineered T cell therapy specific for the hotspot mutation p53 R175H that integrates signal 1 (TCR), signal 2 (co-stimulation) and signal 3 (cytokine) and co-opts FasL-dependent apoptosis to achieve a coordinated antitumor CD4/8 T cell response by Narayan, Santosh, Gareau, Ken, Gupta, Ankit, Ferrell, Josh, Rouillard, Nicholas, Warner, Tyler, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Francis, Joshua, He, Xingyue, Browne, Patrick J., Lamothe, Rebecca, Storlie, Meghan D., Cost, Gregory J., Schmitt, Thomas M., Greenberg, Philip D., Chandran, Smita S., Hallet, Damien, Gormally, Michael, Klebanoff, Chistopher A., Shapiro, Gary, Nguyen, Kim, Vincent, Loïc

“…Adoptive T cell therapy (ACT) has demonstrated antitumor efficacy in patients with solid cancers but requires further optimization to become a reproducibly…”
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Abstract 9: AFNT-212: A TRAC -knocked-in KRASG12D-specific TCR-T cell product enhanced with CD8αβ and a chimeric cytokine receptor for treatment of solid cancers by Drain, Allison, Rouillard, Nicholas, Swanson, Nathaniel, Canestraro, Martina, Narayan, Santosh, Warner, Tyler, Danek, Nicole, Gareau, Ken, Liang, Jinsheng, Shen, Luhua, Tetrault, Tanya, Priyata, Iqraa, Vidyasagar, Sarah, Riggins-Walker, Taylor, Liu, Hui-Wen, Pechhold, Klaus, Brown, Lauren, Francis, Joshua, He, Xingyue, Browne, Patrick, Lamothe, Rebecca, Storlie, Meghan, Cost, Gregory, Schmitt, Thomas M., Greenberg, Philip D., Chandran, Smita S., Klebanoff, Christopher A., Lam, Hubert, Gupta, Ankit, Hallet, Damien, Shapiro, Gary, Nguyen, Kim, Vincent, Loïc

“…The KRASG12D mutation is an ideal target for anti-cancer therapies as its expression is typically clonal, restricted to cancer tissue, and is among the most…”
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