Search Results - "Testi, Claudia"
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Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
Published in Nature communications (08-03-2019)“…Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria…”
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2
Progressive alteration of murine bladder elasticity in actinic cystitis detected by Brillouin microscopy
Published in Scientific reports (04-01-2024)“…Bladder mechanical properties are critical for organ function and tissue homeostasis. Therefore, alterations of tissue mechanics are linked to disease onset…”
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3
Engineered ferritin for lanthanide binding
Published in PloS one (13-08-2018)“…Ferritin H-homopolymers have been extensively used as nanocarriers for diverse applications in the targeted delivery of drugs and imaging agents, due to their…”
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Exploring the Use of Dimethyl Fumarate as Microglia Modulator for Neurodegenerative Diseases Treatment
Published in Antioxidants (01-08-2020)“…The maintenance of redox homeostasis in the brain is critical for the prevention of the development of neurodegenerative diseases. Drugs acting on brain redox…”
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A novel strategy for molecular interfaces optimization: The case of Ferritin-Transferrin receptor interaction
Published in Computational and structural biotechnology journal (01-01-2020)“…Protein-protein interactions regulate almost all cellular functions and rely on a fine tune of surface amino acids properties involved on both molecular…”
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Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues
Published in Current opinion in cell biology (01-06-2024)“…Recent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper execution of physiological functions…”
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Structural analysis of the transferrin receptor multifaceted ligand(s) interface
Published in Biophysical chemistry (01-11-2019)“…The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for most higher organisms. It mediates cellular iron import through a…”
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MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome
Published in Nature genetics (01-12-2020)“…The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin compartments include…”
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Dimethyl Fumarate Reduces Microglia Functional Response to Tissue Damage and Favors Brain Iron Homeostasis
Published in Neuroscience (15-07-2020)“…•Dimethyl fumarate (DMF) is used to treat multiple sclerosis (MS), but very little is known on its mechanism of action.•DMF treatment downregulates microglia…”
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Direct Visualization and Identification of Membrane Voltage‐Gated Sodium Channels from Human iPSC‐Derived Neurons by Multiple Imaging and Light Enhanced Spectroscopy
Published in Small methods (01-07-2022)“…In this study, transmission electron microscopy atomic force microscopy, and surface enhanced Raman spectroscopy are combined through a direct imaging…”
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Direct Visualization and Identification of Membrane Voltage‐Gated Sodium Channels from Human iPSC‐Derived Neurons by Multiple Imaging and Light Enhanced Spectroscopy (Small Methods 7/2022)
Published in Small methods (20-07-2022)“…Direct Visualization In article number 2200402, Moretti, Di Fabrizio, and co‐workers developed a method to directly image and characterize ion channels in…”
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Subcellular localization of the five members of the human steroid 5α-reductase family
Published in Biochimie open (01-06-2017)“…In humans the steroid 5α-reductase (SRD5A) family comprises five integral membrane enzymes that carry out reduction of a double bond in lipidic substrates:…”
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13
Consensus Statement on Brillouin Light Scattering Microscopy of Biological Materials
Published 18-11-2024“…Brillouin Light Scattering (BLS) spectroscopy is a non-invasive, non-contact, label-free optical technique that can provide information on the mechanical…”
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