Search Results - "Testa, N. G."

CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long‐Term Culture‐Initiating Cells, NOD/SCID‐Repopulating Cells and Dendritic Cell Progenitors by de Wynter, E. A., Buck, D., Hart, C., Heywood, R., Coutinho, L. H., Clayton, A., Rafferty, J. A., Burt, D., Guenechea, G., Bueren, J. A., Gagen, D., Fairbairn, L. J., Lord, B. I., Testa, N. G.

“…The AC133 antigen is a novel antigen selectively expressed on a subset of CD34+ cells in human fetal liver, bone marrow, and blood as demonstrated by flow…”
Get full text

Interactions of human prostatic epithelial cells with bone marrow endothelium: binding and invasion by SCOTT, L. J, CLARKE, N. W, GEORGE, N. J. R, SHANKS, J. H, TESTA, N. G, LANG, S. H

“…Prostate cancer shows a propensity to form secondary tumours within the bone marrow. Such tumours are the major cause of mortality in this disease. We have…”
Get full text

Peripheral Blood Progenitor Cell Transplantation in Lymphoma and Leukemia Using a Single Apheresis by Pettengell, R., Morgenstern, G.R., Woll, P.J., Chang, J., Rowlands, M., Young, R., Radford, J.A., Scarffe, J.H., Testa, N.G., Crowther, D.

“…Myeloablative treatment and peripheral blood progenitor cell (PBPC) transplantation are increasingly used for lymphomas and leukemias. We have sought to…”
Get full text

Accelerated telomere shortening in young recipients of allogeneic bone-marrow transplants by Wynn, Robert F, Cross, Michael A, Hatton, Claire, Will, Andrew M, Lashford, Linda S, Dexter, T Michael, Testa, Nydia G

“…The establishment of donor-derived haemopoiesis in the recipients of allogeneic bone-marrow transplants (BMT) involves extensive proliferation of haemopoietic…”
Get full text

Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer by BRONCHUD, M. H, SCARFFE, J. H, THATCHER, N, CROWTHER, D, SOUZA, L. M, ALTON, N. K, TESTA, N. G, DEXTER, T. M

“…Twelve patients with advanced small cell carcinoma of the bronchus were treated by continuous infusion of recombinant human granulocyte colony-stimulating…”
Get full text

Growth of human umbilical-cord blood in longterm haemopoietic cultures by Hows, J M, Bradley, B A, Marsh, J C, Luft, T, Coutinho, L, Testa, N G, Dexter, T M

“…Cryopreserved human umbilical-cord (HUC) blood is an alternative to bone marrow as a source of haemopoietic "stem" cells for HLA-identical transplantation of…”
Get more information

Accelerated telomere shortening following allogeneic transplantation is independent of the cell source and occurs within the first year post transplant by ROBERTSON, J. D, TESTA, N. G, RUSSELL, N. H, JACKSON, G, PARKER, A. N, MILLIGAN, D. W, STAINER, C, CHAKRABARTI, S, DOUGAL, M, CHOPRA, R

“…Telomere shortening has been documented in the blood cells of recipients of allogeneic bone marrow transplants compared with their donors. Allogeneic…”
Get full text

Multicyclic, dose-intensive chemotherapy supported by sequential reinfusion of hematopoietic progenitors in whole blood by Pettengell, R, Woll, P J, Thatcher, N, Dexter, T M, Testa, N G

“…To support multicyclic, dose-intensive chemotherapy, we assessed the effects of reinfusing hematopoietic progenitors collected at each cycle in leukapheresis…”
Get more information

Direct Comparison by Limiting Dilution Analysis of Long-Term Culture-Initiating Cells in Human Bone Marrow, Umbilical Cord Blood, and Blood Stem Cells by Pettengell, Ruth, Luft, Thomas, Henschler, Reinhard, Hows, Jill M., Dexter, T. Michael, Ryder, David, Testa, Nydia G.

“…Limiting-dilution analysis of long-term culture-initiating cells (LTCIC) is a quantitative method of estimating hematopoietic stem cell activity in clinical…”
Get full text

NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor by DE WYNTER, E. A, HEYWORTH, C. M, MUKAIDA, N, MATSUSHIMA, K, TESTA, N. G

“…Human haemopoietic stem and progenitor cells may be distinguished by the pattern of cell surface markers they display. The cells defined as 'stem' cells are…”
Get full text

Randomized comparison of progenitor-cell mobilization using chemotherapy, stem-cell factor, and filgrastim or chemotherapy plus filgrastim alone in patients with ovarian cancer by Weaver, A, Chang, J, Wrigley, E, de Wynter, E, Woll, P J, Lind, M, Jenkins, B, Gill, C, Wilkinson, P M, Pettengell, R, Radford, J A, Collins, C D, Dexter, T M, Testa, N G, Crowther, D

“…This was the first randomized study to investigate the efficacy of peripheral-blood progenitor cell (PBPC) mobilization using stem-cell factor (SCF) in…”
Get more information

Multicentre European study comparing selection techniques for the isolation of CD34+ cells by DE WYNTER, E. A, RYDER, D, LANZA, F, NADALI, G, JOHNSEN, H, DENNING-KENDALL, P, THING-MORTENSEN, B, SILVESTRI, F, TESTA, N. G

“…Primitive haemopoietic cells are required for studies in both the clinical and research fields and a number of systems have been developed to facilitate…”
Get full text

Detection of hTERT protein by flow cytometry by ALI, A. S. M, CHOPRA, R, ROBERTSON, J, TESTA, N. G

“…Telomerase is a telomere-specific DNA polymerase consisting of protein and RNA components, which is activated in germline cells and the majority of cancers and…”
Get full text

Stem cell factor leads to reduced blood processing during apheresis or the use of whole blood aliquots to support dose-intensive chemotherapy by WEAVER, A, TESTA, N. G

“…The addition of stem cell factor (SCF) to G-CSF and chemotherapy results in a dose-dependent, significantly increased mobilisation of peripheral blood…”
Get full text

The Hematopoietic Defect in Aplastic Anemia Assessed by Long-Term Marrow Culture by Marsh, J.C.W., Chang, J., Testa, N.G., Hows, J.M., Dexter, T.M.

“…Thirty-two patients with aplastic anemia (AA) have been studied using the long-term bone marrow culture (LTBMC) system. Of these patients, 26 had been treated…”
Get full text

Increased Numbers of Long-Term Culture-Initiating Cells in the Apheresis Product of Patients Randomized to Receive Increasing Doses of Stem Cell Factor Administered in Combination With Chemotherapy and a Standard Dose of Granulocyte Colony-Stimulating Factor by Weaver, A., Ryder, D., Crowther, D., Dexter, T.M., Testa, N.G.

“…Long-term culture-initiating cells (LTC-IC) are arguably the most primitive human hematopoietic cells detectable by in vitro functional assays. We have…”
Get full text

In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients by BRONCHUD, M. H, POTTER, M. R, DEXTER, T. M, MORGENSTERN, G, BLASCO, M. J, SCARFFE, J. H, THATCHER, N, CROWTHER, D, SOUZA, L. M, ALTON, N. K, TESTA, N. G

“…Twelve patients with small cell lung cancer were treated with recombinant human granulocyte colony-stimulating factor, rhG-CSF, given by continuous infusion at…”
Get full text

Viability of haemopoietic progenitors from whole blood, bone marrow and leukapheresis product: effects of storage media, temperature and time by Pettengell, R, Woll, P J, O'Connor, D A, Dexter, T M, Testa, N G

“…High-dose cytotoxic chemotherapy can be supported with autologous haemopoietic cells. Cryopreserved bone marrow has conventionally been used for this but blood…”
Get more information

Investigation of mammary epithelial cell‐bone marrow stroma interactions using primary human cell culture as a model of metastasis by Brooks, B., Bundred, N.J., Howell, A., Lang, S.H., Testa, N.G.

“…A model has been established using primary human cell culture to study the cell biology of breast cancer metastasis to bone marrow. Mammary epithelia were…”
Get full text

Characterisation of the differential response of normal and CML haemopoietic progenitor cells to macrophage inflammatory protein-1α by DÜRIG, J, TESTA, N. G, LORD, B. I, KASPER, C, CHANG, J, TELFORD, N, DEXTER, T. M, HEYWORTH, C. M

“…The clonogenic cells of chronic myeloid leukaemia (CML), unlike normal haemopoietic colony forming cells (CFC), are resistant to the growth inhibitory effects…”
Get full text